A scoping review of human pathogens detected in untreated human wastewater and sludge DOI Creative Commons
Tricia Corrin, Prakathesh Rabeenthira, Kaitlin M. Young

и другие.

Journal of Water and Health, Год журнала: 2024, Номер 22(2), С. 436 - 449

Опубликована: Янв. 16, 2024

Abstract Wastewater monitoring is an approach to identify the presence or abundance of pathogens within a population. The objective this scoping review (ScR) was and characterize research on human antimicrobial resistance detected in untreated wastewater sludge. A search conducted up March 2023 standard ScR methodology followed. This included 1,722 articles, which 56.5% were published after emergence COVID-19. Viruses bacteria commonly investigated, while protozoa, helminths, fungi infrequent. Articles prior 2019 dominated by transmitted through fecal–oral waterborne pathways, whereas more recent articles have explored detection other pathways such as respiratory vector-borne. There variation sampling, samples, sample processing across studies. current evidence suggests that could be applied range public health tool detect emerging pathogen understand burden spread disease inform decision-making. Further development refinement methods interpret signals for different prioritized are needed develop standards when, why, how monitor effectively.

Язык: Английский

Viral variant-resolved wastewater surveillance of SARS-CoV-2 at national scale DOI Open Access
Fabian Amman, Rudolf Markt, Lukas Endler

и другие.

Nature Biotechnology, Год журнала: 2022, Номер 40(12), С. 1814 - 1822

Опубликована: Июль 18, 2022

Язык: Английский

Процитировано

149
Wastewater-based surveillance is an efficient monitoring tool for tracking influenza A in the community DOI Creative Commons
K. Lehto, Annika Länsivaara, Rafiqul Hyder

и другие.

Water Research, Год журнала: 2024, Номер 257, С. 121650 - 121650

Опубликована: Апрель 21, 2024

Around the world, influenza A virus has caused severe pandemics, and risk of future pandemics remains high. Currently, surveillance is based on clinical diagnosis reporting disease cases. In this study, we apply wastewater-based to monitor amount RNA at population level. We report levels in 10 wastewater treatment plant catchment areas covering 40% Finnish population. Altogether, 251 monthly composite influent samples (collected between February 2021 2023) were analysed from supernatant fraction using specific RT-qPCR method. During study period, an epidemic occurred three waves Finland. This shows that can be detected 24 h samples. The gene copy number correlated with confirmed cases National Infectious Diseases Register. median Kendall's τ correlation strength was 0.636 (min= 0.486 max=0.804) it statistically significant all WTTPs. Wastewater-based independent individual testing method cost-efficiently reflects circulation entire Thus, monitoring complements available, but often too sparse, information improves health care public preparedness for pandemics.

Язык: Английский

Процитировано

19
Making waves: Wastewater surveillance of SARS-CoV-2 in an endemic future DOI
Fuqing Wu, Wei Lin Lee, Hongjie Chen

и другие.

Water Research, Год журнала: 2022, Номер 219, С. 118535 - 118535

Опубликована: Май 3, 2022

Язык: Английский

Процитировано

63
Passive sampling to scale wastewater surveillance of infectious disease: Lessons learned from COVID-19 DOI Creative Commons
Aaron Bivins, Devrim Kaya, Warish Ahmed

и другие.

The Science of The Total Environment, Год журнала: 2022, Номер 835, С. 155347 - 155347

Опубликована: Апрель 21, 2022

Much of what is known and theorized concerning passive sampling techniques has been developed considering chemical analytes. Yet, historically, biological analytes, such as Salmonella typhi, have collected from wastewater via with Moore swabs. In response to the COVID-19 pandemic, re-emerging a promising technique monitor SARS-CoV-2 RNA in wastewater. Method comparisons disease surveillance using composite, grab, for detection found variety materials routinely produced qualitative results superior grab samples useful sub-sewershed COVID-19. Among individual studies, concentrations derived samplers demonstrated heterogeneous correlation paired composite ranging weak (R2 = 0.27, 0.31) moderate 0.59) strong 0.76). sampler materials, electronegative membranes shown great promise linear uptake observed exposure durations 24 48 h several cases positivity on par samples. Continuing development methods infectious diseases diverse forms fecal waste should focus optimizing efficient recovery kit-free extraction, resource-efficient testing capable rapidly producing or quantitative data. With refinements could prove be fundamental tool scaling disease, especially among 1.8 billion persons living low-resource settings served by non-traditional collection infrastructure.

Язык: Английский

Процитировано

57
Microbiome Analysis for Wastewater Surveillance during COVID-19 DOI Creative Commons
Kyle D. Brumfield, Menu Leddy, Moiz Usmani

и другие.

mBio, Год журнала: 2022, Номер 13(4)

Опубликована: Июнь 21, 2022

Wastewater surveillance (WS), when coupled with advanced molecular techniques, offers near real-time monitoring of community-wide transmission SARS-CoV-2 and allows assessing mitigating COVID-19 outbreaks, by evaluating the total microbial assemblage in a community. Composite wastewater samples (24 h) were collected weekly from manhole between December 2020 November 2021 Maryland, USA. RT-qPCR results showed concentrations RNA recovered reflected incidence cases. When drastic increase was detected February 2021, selected for microbiome analysis (DNA metagenomics, metatranscriptomics, targeted sequencing). Targeted sequencing allowed detection important genetic mutations, such as spike: K417N, D614G, P681H, T716I, S982A, D1118H, commonly associated increased cell entry reinfection. Microbiome RNA) provided insight respect to human health-related factors, including pathogens their virulence/antibiotic resistance genes. Specific species comprising correlated RNA, suggesting potential association infection. Climatic conditions, namely, temperature, related wastewater, having been monitored part an environmental risk score assessment carried out this study. In summary, provides useful public health information, hence, valuable tool proactively detect characterize pathogenic agents circulating effect, metagenomics can serve early warning system communicable diseases, providing larger source information departments officials.

Язык: Английский

Процитировано

57
A global aircraft-based wastewater genomic surveillance network for early warning of future pandemics DOI Creative Commons
Jiaying Li,

Ian Hosegood,

David Powell

и другие.

The Lancet Global Health, Год журнала: 2023, Номер 11(5), С. e791 - e795

Опубликована: Апрель 14, 2023

Язык: Английский

Процитировано

32
Ultrasonic cavitation: Tackling organic pollutants in wastewater DOI
Kai Song, Yijun Liu, Ahmad Umar

и другие.

Chemosphere, Год журнала: 2023, Номер 350, С. 141024 - 141024

Опубликована: Дек. 24, 2023

Язык: Английский

Процитировано

26
Structured Ethical Review for Wastewater-Based Testing in Support of Public Health DOI Creative Commons
Devin A. Bowes, Amanda Darling, Erin M. Driver

и другие.

Environmental Science & Technology, Год журнала: 2023, Номер 57(35), С. 12969 - 12980

Опубликована: Авг. 23, 2023

Wastewater-based testing (WBT) for SARS-CoV-2 has rapidly expanded over the past three years due to its ability provide a comprehensive measurement of disease prevalence independent clinical testing. The development and simultaneous application WBT measured biomarkers research activities pursuit public health goals, both areas with well-established ethical frameworks. Currently, practitioners do not employ standardized review process, introducing potential adverse outcomes professionals community members. To address this deficiency, an interdisciplinary workshop developed framework structured WBT. employed consensus approach create as set 11 questions derived from primarily guidance. This study retrospectively applied these monitoring programs covering emergent phase pandemic (3/2020-2/2022 (

Язык: Английский

Процитировано

23
Simultaneous detection and quantification of multiple pathogen targets in wastewater DOI Creative Commons
Gouthami Rao, Drew Capone, Kevin Zhu

и другие.

PLOS Water, Год журнала: 2024, Номер 3(2), С. e0000224 - e0000224

Опубликована: Фев. 1, 2024

Wastewater-based epidemiology has emerged as a critical tool for public health surveillance, building on decades of environmental surveillance work pathogens such poliovirus. Work to date been limited monitoring single pathogen or small numbers in targeted studies; however, few studies consider simultaneous quantitative analysis wide variety pathogens, which could greatly increase the utility wastewater surveillance. We developed novel multi-pathogen approach (35 targets including bacteria, viruses, protozoa, and helminths) using TaqMan Array Cards (TAC) applied method concentrated samples collected at four treatment plants Atlanta, GA from February October 2020. From sewersheds serving approximately 2 million people, we detected range many expected find (e.g., enterotoxigenic E . coli Giardia 97% 29 stable concentrations) well unexpected Strongyloides stercoralis (a human threadworm rarely observed USA). Other notable detections included SARS-CoV-2, but also several that are not commonly like Acanthamoeba spp., Balantidium , Entamoeba histolytica astrovirus, norovirus, sapovirus. Our data suggest broad expanding scope enteric wastewaters, with potential application settings where quantification fecal waste streams can inform selection control measures limit infections.

Язык: Английский

Процитировано

15
Global wastewater surveillance for pathogens with pandemic potential: opportunities and challenges DOI Creative Commons
Nicholas C. Grassly, Alex Shaw, Michael Owusu

и другие.

The Lancet Microbe, Год журнала: 2024, Номер unknown, С. 100939 - 100939

Опубликована: Авг. 1, 2024

SummaryWastewater surveillance holds great promise as a sensitive method to detect spillover of zoonotic infections and early pandemic emergence, thereby informing risk mitigation public health response. Known viruses with potential are shed in human stool or urine, both, the experiences SARS-CoV-2, monkeypox virus, Zika virus highlight feasibility community-based wastewater for that have different transmission routes. We reviewed shedding data prototype representing viral families concern estimate likely sensitivity compared clinical surveillance. examined how on detection, together genetic sequences animal faecal biomarkers, could be used identify adaptation. The opportunities challenges associated global prevention pandemics described this Personal View, focusing low-income middle-income countries, where emergence is highest. propose research agenda ensure an equitable sustainable solution these challenges.

Язык: Английский

Процитировано

13