Bio-inspired electronics: Soft, biohybrid, and “living” neural interfaces

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 21, 2025

Neural interface technologies are increasingly evolving towards bio-inspired approaches to enhance integration and long-term functionality. Recent strategies merge soft materials with tissue engineering realize biologically-active and/or cell-containing living layers at the tissue-device that enable seamless biointegration novel cell-mediated therapeutic opportunities. This review maps field of electronics discusses key recent developments in tissue-like regenerative bioelectronics, from biomaterials surface-functionalized bioactive coatings 'biohybrid' 'all-living' interfaces. We define contextualize terminology this emerging highlight how biological components can bridge gap clinical translation.

Язык: Английский

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Nanomaterial-based biohybrid hydrogel in bioelectronics

Nano Convergence, Год журнала: 2023, Номер 10(1)

Опубликована: Фев. 10, 2023

Abstract Despite the broadly applicable potential in bioelectronics, organic/inorganic material-based bioelectronics have some limitations such as hard stiffness and low biocompatibility. To overcome these limitations, hydrogels capable of bridging interface connecting biological materials electronics been investigated for development hydrogel bioelectronics. Although shown unique properties including flexibility biocompatibility, there are still developing novel using only their electrical conductivity structural stability. As an alternative solution to address issues, studies on biohybrid that incorporating nanomaterials into conducted bioelectronic applications. Nanomaterials complement shortcomings applications, provide new functionality In this review, we recent Firstly, representative constituting provided, next, applications categorized flexible/wearable devices, tissue engineering, biorobotics discussed with studies. conclusion, strongly believe review provides latest knowledge strategies through combination hydrogels, direction future Graphical

Язык: Английский

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AI-enhanced biomedical micro/nanorobots in microfluidics

Lab on a Chip, Год журнала: 2024, Номер 24(5), С. 1419 - 1440

Опубликована: Янв. 1, 2024

Although developed independently at the beginning, AI, micro/nanorobots and microfluidics have become more intertwined in past few years which has greatly propelled cutting-edge development fields of biomedical sciences.

Язык: Английский

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Biofabrication of Living Actuators

Annual Review of Biomedical Engineering, Год журнала: 2024, Номер 26(1), С. 223 - 245

Опубликована: Июль 3, 2024

The impact of tissue engineering has extended beyond a traditional focus in medicine to the rapidly growing realm biohybrid robotics. Leveraging living actuators as functional components machines been central this field, generating range compelling demonstrations robots capable muscle-powered swimming, walking, pumping, gripping, and even computation. In review, we highlight key advances fabricating tissue-scale cardiac skeletal muscle for applications. We discuss areas future growth including scalable manufacturing, integrated feedback control, predictive modeling also propose methods ensuring inclusive bioethics-focused pedagogy emerging discipline. hope review motivates next generation biomedical engineers advance rational design practical use applications ranging from telesurgery manufacturing on- off-world exploration.

Язык: Английский

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The Impact of Cloud Versus Local Infrastructure on Automatic IoT-Driven Hydroponic Systems

Applied Sciences, Год журнала: 2025, Номер 15(7), С. 4016 - 4016

Опубликована: Апрель 5, 2025

Technological advancements in the cloud field are becoming widely used on a large scale increasing activity sectors. Agriculture is an important domain everyday life, central to human existence. This research comparatively analyzes two proposed types of infrastructures that optimize growth flow plants hydroponic system for continuous monitoring, one full-cloud and full-local. The study’s main objective determine which more suitable scenario by conducting seven tests. aims fill gap specialized literature through detailed analysis configuration, implementation methods, all implications approaches from perspective indicators. indicators response time, operational reliability, costs, configuration scalability, data accessibility, security. infrastructure uses Microsoft Azure technologies, while local variant custom-made scripts locally installed services. For both software infrastructures, hardware components identical, including M5Stack module with sensors monitoring temperature, humidity, electrical conductivity, liquid level container. test results highlight offers shorter time (200 ms compared 300 infrastructure). also showed lower costs infrastructure, making it autonomous systems. On other hand, has greater accessibility than security measures advanced. These advantages involve recurring USD 82.57/month. limitations this associated exclusion errors cybernetics simulations analysis. Another limitation concerns real short-term costs. Future will explore fluctuations long-term Additionally, studies different plant species farms be considered.

Язык: Английский

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Microfluidic platforms for monitoring cardiomyocyte electromechanical activity

Microsystems & Nanoengineering, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 9, 2025

Abstract Cardiovascular diseases account for ~40% of global deaths annually. This situation has revealed the urgent need investigation and development corresponding drugs pathogenesis due to complexity research methods detection techniques. An in vitro cardiomyocyte model is commonly used cardiac drug screening disease modeling since it can respond microphysiological environmental variations through mechanoelectric feedback. Microfluidic platforms are capable accurate fluid control integration with analysis Therefore, various microfluidic (i.e., heart-on-a-chip) have been applied reconstruction physiological environment signals from cardiomyocytes. They demonstrated advantages mimicking cardiovascular structure function monitoring electromechanical signals. review presents a summary technologies monitor contractility electrophysiological cardiomyocytes within platforms. Then, applications common presented, followed by design strategies enhancing physiology studies. Finally, we discuss prospects tissue engineering sensing techniques

Язык: Английский

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Next-Generation Microfluidics for Biomedical Research and Healthcare Applications

Biomedical Engineering and Computational Biology, Год журнала: 2023, Номер 14

Опубликована: Янв. 1, 2023

Microfluidic systems offer versatile biomedical tools and methods to enhance human convenience health. Advances in these enables next-generation microfluidics that integrates automation, manipulation, smart readout systems, as well design three-dimensional (3D) printing for precise production of microchannels other microstructures rapidly with great flexibility. These 3D-printed microfluidic platforms not only control the complex fluid behavior various applications, but also serve microconduits building 3D tissue constructs—an integral component advanced drug development, toxicity assessment, accurate disease modeling. Furthermore, integration emerging technologies, such microscopy robotics, spatiotemporal manipulation high-throughput screening cell physiology within precisely controlled microenvironments. Notably, portability high precision automation capabilities integrated facilitate rapid experimentation data acquisition help deepen our understanding biological their behaviors. While certain challenges, including material compatibility, scaling, standardization still exist, artificial intelligence, Internet Things, materials, miniaturization holds tremendous promise reshaping traditional approaches. This transformative potential, when has potential revolutionize research healthcare ultimately benefiting review highlights advances field emphasizes critical role next generation advancing research, point-of-care diagnostics, systems.

Язык: Английский

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Living cell‐laden hydrogels: Unleashing the future of responsive biohybrid systems

Deleted Journal, Год журнала: 2023, Номер 1(1)

Опубликована: Авг. 1, 2023

Abstract Responsive biohybrid systems have the potential to overcome limitations of both natural and artificial machines in terms efficiency, accuracy, functionality. As functional units, living cells act as bricks for building machines, where extracellular matrix mimics hydrogels ideal biological concrete. Combining with offers unique advantages simulating human tissues or organs, which unleashes future systems, thus has attracted extensive attention. Herein, recent progress cell‐laden hydrogel‐based responsive is summarized provide a basic understanding how these are built from bottom up achieve complex functions. This review focuses on advanced manufacturing technologies including laden hydrogel matrices, three‐dimensional bioprinting, microfluidic manufacturing. Subsequently, innovative applications works, actuators, sensors, engineered materials, presented, along different triggering mechanisms that highlighted. Finally, current challenges opportunities field addressed. provides perspective hoped inspire fields such technologies, soft robots, tissue engineering.

Язык: Английский

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Perfusable Biohybrid Designs for Bioprinted Skeletal Muscle Tissue

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(18)

Опубликована: Март 13, 2023

Engineered, centimeter-scale skeletal muscle tissue (SMT) can mimic pathophysiology to study development, disease, regeneration, drug response, and motion. Macroscale SMT requires perfusable channels guarantee cell survival, support elements enable mechanical stimulation uniaxial myofiber formation. Here, stable biohybrid designs of are realized via extrusion-based bioprinting an optimized polymeric blend based on gelatin methacryloyl sodium alginate, which be accurately coprinted with other inks. A microchannel network is designed functionally integrate anchors for insertion into a maturation culture template. The results demonstrate that i) synthetic structures display highly coherent interfaces the living tissue, ii) preserve cells from hypoxia all over scaffold volume, iii) constructs undergo passive tension during matrix remodeling, iv) used distribution drugs. Extrusion-based multimaterial inks design realizes in vitro matured biomedical applications.

Язык: Английский

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Robots that evolve on demand

Nature Reviews Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 12, 2024

Язык: Английский

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