Korean Journal of Otorhinolaryngology - Head and Neck Surgery, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 14, 2024
Pharmaceuticals, Год журнала: 2023, Номер 17(1), С. 22 - 22
Опубликована: Дек. 22, 2023
In the dynamic landscape of drug discovery, Computer-Aided Drug Design (CADD) emerges as a transformative force, bridging realms biology and technology. This paper overviews CADDs historical evolution, categorization into structure-based ligand-based approaches, its crucial role in rationalizing expediting discovery. As CADD advances, incorporating diverse biological data ensuring privacy become paramount. Challenges persist, demanding optimization algorithms robust ethical frameworks. Integrating Machine Learning Artificial Intelligence amplifies predictive capabilities, yet considerations scalability challenges linger. Collaborative efforts global initiatives, exemplified by platforms like Open-Source Malaria, underscore democratization The convergence with personalized medicine offers tailored therapeutic solutions, though dilemmas accessibility concerns must be navigated. Emerging technologies quantum computing, immersive technologies, green chemistry promise to redefine future CADD. trajectory CADD, marked rapid advancements, anticipates accuracy, addressing biases AI, sustainability metrics. concludes highlighting need for proactive measures navigating ethical, technological, educational frontiers shape healthier, brighter
Язык: Английский
Процитировано
94
Drug Discovery Today, Год журнала: 2024, Номер 29(4), С. 103936 - 103936
Опубликована: Фев. 29, 2024
This review highlights the transformative impact of microfluidic technology on personalized drug delivery. Microfluidics addresses issues in traditional synthesis, providing precise control and scalability nanoparticle fabrication, platforms show high potential for versatility, offering patient-specific dosing real-time monitoring capabilities, all integrated into wearable technology. Covalent conjugation antibodies to nanoparticles improves bioactivity, driving innovations targeting. The integration microfluidics with sensor technologies artificial intelligence facilitates feedback autonomous adaptation delivery systems. Key challenges, such as droplet polydispersity fluidic handling, along future directions focusing reliability, are essential considerations advancing
Язык: Английский
Процитировано
18
Results in Engineering, Год журнала: 2024, Номер 22, С. 102115 - 102115
Опубликована: Апрель 10, 2024
MEMS, or microelectromechanical systems, have greatly transformed multiple industries with their small size and adaptable capabilities. MEMS technology in biosensing allows for rapid accurate identification of biological analytes, assisting medical diagnoses therapies. MEMS-based biosensors provide label-free detection, improving early disease screening customized medicine administration. devices healthcare enable uninterrupted patient monitoring telemedicine, leading to substantial enhancements results. Nevertheless, obstacles remain, such as the requirement improved biocompatibility durability under very demanding conditions. In order overcome these restrictions, current research is dedicated advancing materials that are compatible living organisms, processes used create small-scale structures, incorporating wireless systems. To fully exploit capabilities biosensors, it crucial prioritize improvements. This will facilitate smooth integration into different contribute industry's significant growth.
Язык: Английский
Процитировано
18
Science Advances, Год журнала: 2025, Номер 11(2)
Опубликована: Янв. 10, 2025
Measuring virus in biofluids is complicated by confounding biomolecules coisolated with viral nucleic acids. To address this, we developed an affinity-based microfluidic device for specific capture of intact severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our approach used engineered angiotensin-converting enzyme to from plasma and other complex biofluids. leverages a staggered herringbone pattern, nanoparticle surface coating, processing conditions achieve detection as few 3 copies per milliliter. We further validated our assay on 103 plasma, 36 saliva, 29 stool samples collected unique patients COVID-19, showing SARS-CoV-2 72% samples. Longitudinal monitoring the revealed device’s capacity ultrasensitive active infections over time. technology can be adapted target viruses using relevant cell entry molecules affinity capture. This versatility underscores potential widespread application load disease management.
Язык: Английский
Процитировано
1
Microsystems & Nanoengineering, Год журнала: 2024, Номер 10(1)
Опубликована: Июль 17, 2024
Abstract This work presents the development and design of aptasensor employing porous silicon (PSi) Fabry‒Pérot thin films that are suitable for use as optical transducers detection lactoferrin (LF), which is a protein biomarker secreted at elevated levels during gastrointestinal (GI) inflammatory disorders such bowel disease chronic pancreatitis. To overcome primary limitation associated with PSi biosensors—namely, their relatively poor sensitivity due to issues related complex mass transfer phenomena reaction kinetics—we employed two strategic approaches: First, we sought optimize nanostructure respect factors including layer thickness, pore diameter, capture probe density. Second, leveraged convection properties by integrating resulting biosensor into 3D-printed microfluidic system also had one different micromixer architectures (i.e., staggered herringbone micromixers or microimpellers) embedded. We demonstrated tailoring significantly improved its performance, achieving limit (LOD) 50 nM—which >1 order magnitude lower than achieved using previously-developed biosensors this type. Moreover, integration systems incorporated passive active further enhanced aptasensor’s sensitivity, an additional reduction in LOD yet another magnitude. These advancements demonstrate potential combining PSi-based technology create sensitive label-free biosensing platforms GI biomarkers.
Язык: Английский
Процитировано
7
TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 181, С. 118004 - 118004
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
6
Micromachines, Год журнала: 2024, Номер 15(2), С. 232 - 232
Опубликована: Фев. 1, 2024
This paper introduces an innovative method for the analysis of alcohol–water droplets on a CMOS capacitive sensor, leveraging controlled thermal behavior droplets. Using this sensing method, sensor measures total time evaporation (ToE), which can be influenced by droplet volume, temperature, and chemical composition. We explored introducing binary mixtures water ethanol or methanol across range concentrations (0–100%, with 10% increments). The experimental results indicate that while is effective in measuring both ToE dielectric properties, higher dynamic resolution are observed former. Additionally, array electrodes successfully monitors droplet–sensor surface interaction. However practical considerations such as creation parasitic capacitance due to mismatch, arise from large area proposed sensors other similar devices. In paper, we discuss non-ideality propose solution. Also, showcases benefits utilizing accurately ToE.
Язык: Английский
Процитировано
4
Talanta, Год журнала: 2024, Номер 275, С. 126139 - 126139
Опубликована: Май 1, 2024
Язык: Английский
Процитировано
4
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 17, 2025
This study advances microfluidic probe (MFP) technology through the development of a 3D-printed Microfluidic Mixing Probe (MMP), which integrates built-in pre-mixer network channels and features lined array paired injection aspiration apertures. By combining concepts hydrodynamic flow confinements (HFCs) "Christmas-tree" concentration gradient generation, MMP can produce multiple concentration-varying dipoles, ranging from 0 to 100%, within an open environment. innovation overcomes previous limitations MFPs, only produced homogeneous bioreagents, by utilizing create distinct injected biochemicals. Experimental results with fluorescent dyes chemotherapeutic agent Cisplatin on MCF-7 cells confirmed MMP's ability generate precise, discrete gradients formed consistent numerical models. The localize drug exposure across cell cultures without cross-contamination opens new avenues for testing, personalized medicine, molecular biology. It enables precise control over delivery, dosage, timing, are key factors in enhancing evaluation processes.
Язык: Английский
Процитировано
0
Tissue Engineering Part B Reviews, Год журнала: 2025, Номер unknown
Опубликована: Апрель 2, 2025
Tissue and organ dysfunction are major causes of worldwide morbidity mortality with all medical specialties being impacted. engineering is an interdisciplinary field relying on the combination scaffolds, cells, biologically active molecules to restore form function. However, clinical translation still largely hampered by limitations in vascularization. Consequently, a thorough understanding microvasculature warranted. This review provides overview (1) angiogenesis, including sprouting intussusceptive vascular remodeling, co-option, inosculation; (2) strategies for vascularized engineered tissue fabrication such as scaffold modulation, prevascularization, growth factor utilization, cell-based approaches; (3) guided microvascular development via modulation electromechanical cues, 3D bioprinting, electrospinning; (4) surgical approaches bridge micro- macrovasculatures order hasten perfusion; (5) building specific vasculature context repair transplantation, skin, adipose, bone, liver, kidney, lung. Our goal provide reader translational that spans developmental biology, engineering, surgery.
Язык: Английский
Процитировано
0