Brain Behavior and Immunity, Год журнала: 2024, Номер 123, С. 840 - 850
Опубликована: Окт. 30, 2024
Язык: Английский
Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(16)
Опубликована: Апрель 9, 2024
Childhood maltreatment (CM) leads to a lifelong susceptibility mental ill-health which might be reflected by its effects on adult brain structure, perhaps indirectly mediated metabolic, immune, and psychosocial systems. Indexing these systemic factors via body mass index (BMI), C-reactive protein (CRP), rates of trauma (AT), respectively, we tested three hypotheses: (H1) CM has direct or indirect trauma, BMI, CRP; (H2) CRP are all independently related structure; (H3) childhood structure in parallel CRP, AT. Using path analysis data from
Язык: Английский
Процитировано
12
Journal of Psychiatric Research, Год журнала: 2025, Номер 182, С. 452 - 461
Опубликована: Янв. 22, 2025
Язык: Английский
Процитировано
0
Psychoneuroendocrinology, Год журнала: 2025, Номер 174, С. 107405 - 107405
Опубликована: Фев. 14, 2025
Язык: Английский
Процитировано
0
Brain Behavior and Immunity, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Childhood maltreatment (CM), i.e. physical, psychological, or sexual abuse and neglect, affects approximately one third of the general population is an important risk factor for all major psychiatric disorders. Exposure to CM also has a profound impact on immune function, with both factors independently implicated in development prognosis different mental This study aims 1) assess differences markers among adults diagnosed disorders without history 2) explore role as mediating abnormalities patients compared non-psychiatric controls. A PRISMA-compliant systematic search PubMed, Web Science Embase databases was performed until October 24th, 2024 original studies that assessed trauma-stratified adult (PROSPERO ID CRD42021273059). We modelled random-effects meta-analyses compare levels pro-inflammatory (PIM), anti-inflammatory (AIM) cellular (CIM) between traumatized (CM + ) non-traumatized (CM-) individuals, investigated exposure Secondary analyses were diagnostic subgroups individual markers. Study quality Newcastle Ottawa Scale. included data from 53 n = 12,141 mood (MD), schizophrenia spectrum (SSD), substance use (SUD), eating (ED) anxiety (AD). uncovered consistent transdiagnostic blood-based molecules (OR 1.186; 95 % CI 1.030-1.365, p 0.018) effect not observed controls same studies. did find evidence specific trauma-induced composite scores separate subgroups, except PIM SUD 2.324, 1.043-5.182, 0.039). Interleukin 6 (IL-6) identified significant mediator diagnosis adulthood 1.609; 1.100-2.353, 0.014), while increases C-reactive protein (CRP) 10 (IL-10) appear be trauma-specific. Our findings confirm increased molecular patients. IL-6 emerged crucial mediator, suggesting leads alterations predisposing individuals conditions. meta-analysis highlights potentially mechanism contributing vulnerability towards illness later life.
Язык: Английский
Процитировано
0
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 111348 - 111348
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Translational Psychiatry, Год журнала: 2024, Номер 14(1)
Опубликована: Окт. 7, 2024
Exposure to adverse life events is linked somatic disorders. The study aims evaluate the association between at varying stages and risk of chronic kidney disease (CKD), a condition affecting about 10% population worldwide. This prospective cohort included 140,997 participants from UK Biobank. Using survey items related childhood maltreatment, adulthood adversity catastrophic trauma, we performed latent class analysis summarize five distinct patterns exposure events, namely "low-level exposure", "childhood "adulthood "sexual abuse" "child-to-adulthood exposure". We used Cox proportional hazard regression with CKD, regression-based mediation decompose total effect, gene-environment-wide interaction (GEWIS) identify interactions genetic loci events. During median follow-up 5.98 years, 2734 cases incident CKD were identified. Compared exposure" pattern, was associated increased (hazard ratio 1.37, 95% CI 1.14 1.65). BMI, smoking hypertension mediated 11.45%, 9.79%, 4.50% this respectively. Other did not show significant results. GEWIS subsequent analyses indicated that magnitude differed according polymorphisms, identified potential underlying pathways (e.g., interleukin 1 receptor activity). These findings underscore importance incorporating an individual's psychological encounters profiles into precision prevention CKD.
Язык: Английский
Процитировано
2
Science Bulletin, Год журнала: 2024, Номер 70(4), С. 573 - 586
Опубликована: Сен. 28, 2024
Язык: Английский
Процитировано
2
CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(7)
Опубликована: Июль 1, 2024
Abstract Objective Childhood sensory abnormalities experience has a crucial influence on the structure and function of adult brain. The underlying mechanism neurological induced by childhood is still unclear. Our study was to investigate whether GABAergic neurons in anterior cingulate cortex (ACC) regulate social disorders caused experience. Methods We used two mouse models, complete Freund's adjuvant (CFA) injection mice bilateral whisker trimming (BWT) childhood. applied immunofluorescence, chemogenetic optogenetic parvalbumin (PV) somatostatin (SST) ACC regulating Results Inflammatory pain leads preference disorders, while BWT novelty mice. an increase number PV SST neurons, respectively, ACC. Inhibiting improved that experienced inflammatory during Conclusions reveals may play critical role
Язык: Английский
Процитировано
1
Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry, Год журнала: 2024, Номер 16(4), С. 691 - 706
Опубликована: Апрель 14, 2024
This paper aims to review the subtypes of childhood trauma and its effects on brain structures function, especially hippocampus amygdala within limbic system, in context clinical psychology. For this purpose, original articles published between 1996 2024 were systematically searched major databases such as PubMed, PsycArticles, Web Science, Google Scholar using keywords early trauma, psychological hippocampus, amygdala, neuroimaging. The initially screened based their titles, those meeting search criteria, including study population, investigated regions, types traumas, further assessed for relevance. Ultimately, 136 selected discussed review. Trauma experiences life can have a significantly negative influence person's health by causing neurodevelopmental impairments, system. While it is understood that influences how individuals think, behave, feel, results neuroimaging studies reveal variations different subtypes. These changes merit deeper investigation future research fully understand reasons behind diverse findings existing literature.
Язык: Английский
Процитировано
0
Clinical Epigenetics, Год журнала: 2024, Номер 16(1)
Опубликована: Авг. 5, 2024
Childhood maltreatment (CM) is linked to long-term adverse health outcomes, including accelerated biological aging and cognitive decline. This study investigates the relationship between CM various biomarkers: telomere length, facial aging, intrinsic epigenetic age acceleration (IEAA), GrimAge, HannumAge, PhenoAge, frailty index, performance.
Язык: Английский
Процитировано
0