Childhood maltreatment influences adult brain structure through its effects on immune, metabolic, and psychosocial factors

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(16)

Published: April 9, 2024

Childhood maltreatment (CM) leads to a lifelong susceptibility mental ill-health which might be reflected by its effects on adult brain structure, perhaps indirectly mediated metabolic, immune, and psychosocial systems. Indexing these systemic factors via body mass index (BMI), C-reactive protein (CRP), rates of trauma (AT), respectively, we tested three hypotheses: (H1) CM has direct or indirect trauma, BMI, CRP; (H2) CRP are all independently related structure; (H3) childhood structure in parallel CRP, AT. Using path analysis data from

Language: Английский

---

Potential Metabolic Sequelae to the Terrorist Attack of October 7th, 2023

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 182, P. 452 - 461

Published: Jan. 22, 2025

Language: Английский

---

Inflammatory biomarkers and childhood maltreatment: a cluster analysis in patients with eating disorders

Psychoneuroendocrinology, Journal Year: 2025, Volume and Issue: 174, P. 107405 - 107405

Published: Feb. 14, 2025

Language: Английский

---

Immune dysregulation in psychiatric disorders with and without exposure to childhood maltreatment: A transdiagnostic stratified meta-analysis

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Childhood maltreatment (CM), i.e. physical, psychological, or sexual abuse and neglect, affects approximately one third of the general population is an important risk factor for all major psychiatric disorders. Exposure to CM also has a profound impact on immune function, with both factors independently implicated in development prognosis different mental This study aims 1) assess differences markers among adults diagnosed disorders without history 2) explore role as mediating abnormalities patients compared non-psychiatric controls. A PRISMA-compliant systematic search PubMed, Web Science Embase databases was performed until October 24th, 2024 original studies that assessed trauma-stratified adult (PROSPERO ID CRD42021273059). We modelled random-effects meta-analyses compare levels pro-inflammatory (PIM), anti-inflammatory (AIM) cellular (CIM) between traumatized (CM + ) non-traumatized (CM-) individuals, investigated exposure Secondary analyses were diagnostic subgroups individual markers. Study quality Newcastle Ottawa Scale. included data from 53 n = 12,141 mood (MD), schizophrenia spectrum (SSD), substance use (SUD), eating (ED) anxiety (AD). uncovered consistent transdiagnostic blood-based molecules (OR 1.186; 95 % CI 1.030-1.365, p 0.018) effect not observed controls same studies. did find evidence specific trauma-induced composite scores separate subgroups, except PIM SUD 2.324, 1.043-5.182, 0.039). Interleukin 6 (IL-6) identified significant mediator diagnosis adulthood 1.609; 1.100-2.353, 0.014), while increases C-reactive protein (CRP) 10 (IL-10) appear be trauma-specific. Our findings confirm increased molecular patients. IL-6 emerged crucial mediator, suggesting leads alterations predisposing individuals conditions. meta-analysis highlights potentially mechanism contributing vulnerability towards illness later life.

Language: Английский

---

Altered neurovascular coupling in depression with childhood maltreatment

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111348 - 111348

Published: April 1, 2025

Language: Английский

---

Sex-dependent impact of parental verbal abuse on brain lateralization of language

Neurobiology of Stress, Journal Year: 2025, Volume and Issue: unknown, P. 100730 - 100730

Published: May 1, 2025

Language: Английский

---

Academic stress psychological – well-being and depression of Vietnamese high school students

Multidisciplinary Science Journal, Journal Year: 2025, Volume and Issue: 7(10), P. 2025485 - 2025485

Published: April 11, 2025

This study explored the connections among academic stress, psychological well-being, and depression high school students. Conducted online in April 2023, it involved 400 students aged 15–17 from Vietnam, who were chosen through convenience sampling. Participants responded to 7-item Depression Scale, 5-item Well-Being Index (WHO-5), 16-item Educational Stress Scale for Adolescents (ESSA). Multiple regression analysis revealed that stress did not have a negative correlation with depression. Similarly, was found negatively influence well-being. These findings underscore complex interplay between The concludes by discussing both theoretical practical implications of these results, offering insights future research could aid scholars practitioners better understanding dynamics depression,

Language: Английский

---

Plasma proteomics identifies proteins and pathways associated with incident depression in 46,165 adults

Science Bulletin, Journal Year: 2024, Volume and Issue: 70(4), P. 573 - 586

Published: Sept. 28, 2024

Language: Английский

---

The association between patterns of exposure to adverse life events and the risk of chronic kidney disease: a prospective cohort study of 140,997 individuals

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 7, 2024

Exposure to adverse life events is linked somatic disorders. The study aims evaluate the association between at varying stages and risk of chronic kidney disease (CKD), a condition affecting about 10% population worldwide. This prospective cohort included 140,997 participants from UK Biobank. Using survey items related childhood maltreatment, adulthood adversity catastrophic trauma, we performed latent class analysis summarize five distinct patterns exposure events, namely "low-level exposure", "childhood "adulthood "sexual abuse" "child-to-adulthood exposure". We used Cox proportional hazard regression with CKD, regression-based mediation decompose total effect, gene-environment-wide interaction (GEWIS) identify interactions genetic loci events. During median follow-up 5.98 years, 2734 cases incident CKD were identified. Compared exposure" pattern, was associated increased (hazard ratio 1.37, 95% CI 1.14 1.65). BMI, smoking hypertension mediated 11.45%, 9.79%, 4.50% this respectively. Other did not show significant results. GEWIS subsequent analyses indicated that magnitude differed according polymorphisms, identified potential underlying pathways (e.g., interleukin 1 receptor activity). These findings underscore importance incorporating an individual's psychological encounters profiles into precision prevention CKD.

Language: Английский

---

Associations between childhood maltreatment, peripheral immune biomarkers, and psychiatric symptoms in adults: A cohort study of over 138,000 participants

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 123, P. 840 - 850

Published: Oct. 30, 2024

Language: Английский

---