Pharmaceutics,
Год журнала:
2025,
Номер
17(6), С. 682 - 682
Опубликована: Май 22, 2025
Cancer
remains
a
formidable
global
health
challenge
due
to
its
complex
pathophysiology
and
resistance
conventional
treatments.
In
recent
years,
the
convergence
of
nanotechnology
oncology
has
paved
way
for
innovative
therapeutic
platforms
that
address
limitations
traditional
modalities.
This
review
examines
how
nanoparticle
(NP)-based
strategies
enhance
efficacy
chemotherapy,
radiotherapy,
phototherapy,
immunotherapy,
gene
therapy
by
enabling
targeted
delivery,
controlled
drug
release,
tumor-specific
accumulation
via
enhanced
permeability
retention
(EPR)
effect.
We
discuss
design
functionalization
various
organic,
inorganic,
hybrid
NPs,
highlighting
their
roles
in
improving
pharmacokinetics,
overcoming
multidrug
resistance,
modulating
tumor
microenvironment.
Particular
emphasis
is
placed
on
dual
multimodal
therapies,
such
as
chemo-phototherapy,
chemo-immunotherapy,
gene-radiotherapy,
leverage
carriers
amplify
synergistic
effects,
minimize
systemic
toxicity,
improve
clinical
outcomes.
also
explore
cutting-edge
advances
editing
personalized
nanomedicine,
well
emerging
biological
barriers
immunosuppressive
mechanisms
niche.
Despite
undeniable
promise
nanoparticle-based
cancer
challenges
related
scalable
manufacturing,
regulatory
oversight,
long-term
biocompatibility
must
be
overcome
before
they
can
fully
enter
practice.
By
synthesizing
findings
identifying
key
opportunities
innovation,
this
provides
insight
into
nanoscale
are
propelling
next
generation
precision
oncology.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Cancer
immunotherapy,
which
leverages
immune
system
components
to
treat
malignancies,
has
emerged
as
a
cornerstone
of
contemporary
therapeutic
strategies.
Yet,
critical
concerns
about
the
efficacy
and
safety
cancer
immunotherapies
remain
formidable.
Nanotechnology,
especially
polymeric
nanoparticles
(PNPs),
offers
unparalleled
flexibility
in
manipulation‐from
chemical
composition
physical
properties
precision
control
nanoassemblies.
PNPs
provide
an
optimal
platform
amplify
potency
minimize
systematic
toxicity
broad
spectrum
immunotherapeutic
modalities.
In
this
comprehensive
review,
basics
polymer
chemistry,
state‐of‐the‐art
designs
from
physicochemical
standpoint
for
encompassing
vaccines,
situ
vaccination,
adoptive
T‐cell
therapies,
tumor‐infiltrating
cell‐targeted
antibodies,
cytokine
therapies
are
delineated.
Each
immunotherapy
necessitates
distinctively
tailored
design
strategies
nanoplatforms.
The
extensive
applications
PNPs,
investigation
their
mechanisms
action
enhanced
particularly
focused
on.
profiles
clinical
research
progress
discussed.
Additionally,
forthcoming
developments
emergent
trends
nano‐immunotherapeutics
poised
transform
treatment
paradigms
into
clinics
explored.
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 13, 2025
Colorectal
cancer
(CRC)
is
the
third
most
prevalent
malignancy
and
second
leading
cause
of
cancer-related
mortality
worldwide,
with
an
increasing
shift
towards
younger
age
onset.
In
recent
years,
there
has
been
recognition
significance
tRNA-derived
small
RNAs
(tsRNAs),
encompassing
fragments
(tRFs)
tRNA
halves
(tiRNAs).
Their
involvement
in
regulating
translation,
gene
expression,
reverse
transcription,
epigenetics
gradually
come
to
light.
Emerging
research
revealed
dysregulation
tsRNAs
CRC,
implicating
their
role
CRC
initiation
progression,
highlighting
potential
early
diagnosis,
prognosis,
therapeutic
strategies.
Although
clinical
application
still
its
stages,
findings
highlight
a
close
relationship
between
biogenesis
function
tsRNAs,
chemical
modifications,
tumor
immune
microenvironment
(TIME).
Additionally,
similar
other
RNAs,
can
be
effectively
delivered
via
nanoparticles
(NPs).
Consequently,
future
should
focus
on
elucidating
concerning
base
TIME
regulation,
immunotherapy,
NPs
delivery
systems
facilitate
translation.
Abstract
RNAi
technologies
have
been
exploited
to
control
viruses,
pests,
oomycetes,
and
fungal
phytopathogens
that
cause
disasters
in
host
plants,
including
many
agronomically
significant
crops.
Double‐stranded
RNA
(dsRNA)
or
small
interfering
(siRNA)
has
applied
as
a
trigger
for
trans‐kingdom
between
hosts
fungi.
However,
it
is
unclear
what
process
mediates
uptake
by
In
this
study,
using
live‐cell
imaging,
we
determined
exogenously
synthesized
(sRNA)
was
indiscriminately
absorbed
into
Verticillium
dahliae
,
notorious
pathogenic
fungus.
Moreover,
the
application
of
endocytic
inhibitors
deletion
endocytic‐related
genes
reduced
efficiency,
showing
absorption
cells
occurs
mainly
through
endocytosis.
addition,
found
endocytosed
fluorescence‐labeled
RNAs
were
partly
colocalized
with
endosome
marker
genes.
Overall,
our
research
concluded
exogenous
could
be
assimilated
V.
pathway.
Unraveling
cytological
mechanism
underlying
holds
importance,
especially
considering
fact
RNAi‐based
strategies
targeting
fungi
are
increasingly
prevalent
realm
crop
protection.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
Abstract
Acute
lung
injury
(ALI)
is
a
clinically
critical
disease
characterized
by
overwhelming
inflammatory
response
and
significant
tissue
damage
with
no
specific
treatment
available
currently.
As
key
player
in
the
pathogenesis
of
ALI,
macrophages
are
aberrantly
activated
polarize
toward
pro‐inflammatory
phenotypes,
leading
to
overzealous
inflammation
injury.
Mitochondria
recognized
as
crucial
signaling
hub
governing
macrophage
function
polarization,
deregulation
which
causatively
related
defective
metabolism
macrophages,
deregulated
inflammation,
hence
ALI.
Herein,
an
inflammation‐responsive,
biomimetic
metal‐organic
framework
(MOF)
nanoplatform,
termed
a127/mito@ZIF@Ma
developed,
sophistically
designed
for
synergistic
delivery
macrophage‐derived
mitochondria
anti‐inflammatory
miRNA‐127
antagonist
resume
pulmonary
homeostasis
alleviate
Notably,
membrane
encapsulation
conferred
MOF
enhanced
transport
efficacy
both
vitro
vivo.
Therefore,
administration
nanoparticles
accordingly
profound
protection
mice
against
induced
either
bacterial
or
viral
infection
unnoticeable
toxicity.
The
study
thus
devises
novel
MOF‐based
nanosystem
that
integrates
transplantation
miRNA
therapeutics,
may
open
new
avenue
treating
ALI
relevant
diseases.
ACS Nano,
Год журнала:
2024,
Номер
18(24), С. 15729 - 15743
Опубликована: Июнь 5, 2024
Lipid
nanoparticles
(LNP)
have
emerged
as
pivotal
delivery
vehicles
for
RNA
therapeutics.
Previous
research
and
development
usually
assumed
that
LNPs
are
homogeneous
in
population,
loading
density,
composition.
Such
perspectives
difficult
to
examine
due
the
lack
of
suitable
tools
characterize
these
physicochemical
properties
at
single-nanoparticle
level.
Here,
we
report
an
integrated
spectroscopy-chromatography
approach
a
generalizable
strategy
dissect
complexities
multicomponent
LNP
assembly.
Our
platform
couples
cylindrical
illumination
confocal
spectroscopy
(CICS)
with
free
solution
hydrodynamic
separation
(SN-FSHS)
simultaneously
profile
population
identity,
size,
levels,
distributions
helper
lipid
PEGylated
single-particle
level
high-throughput
manner.
Using
benchmark
siRNA
formulation,
demonstrate
capability
this
by
distinguishing
seven
distinct
populations,
quantitatively
characterizing
size
distribution
wide
ranges,
more
importantly,
resolving
composition-size
correlations.
This
SN-FSHS-CICS
analysis
provides
critical
insights
into
substantial
degree
heterogeneity
packing
density
size-dependent
loading-size
correlations,
explained
kinetics-driven
assembly
mechanisms
LNPs.
