The Impact of COVID-19 on RNA Therapeutics: A Surge in Lipid Nanoparticles and Alternative Delivery Systems DOI Creative Commons
Nargish Parvin, Tapas Kumar Mandal, Sang‐Woo Joo

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1366 - 1366

Published: Oct. 25, 2024

The COVID-19 pandemic has significantly accelerated progress in RNA-based therapeutics, particularly through the successful development and global rollout of mRNA vaccines. This review delves into transformative impact on RNA with a strong focus lipid nanoparticles (LNPs) as pivotal delivery platform. LNPs have proven to be critical enhancing stability, bioavailability, targeted mRNA, facilitating unprecedented success vaccines like those developed by Pfizer-BioNTech Moderna. Beyond vaccines, LNP technology is being explored for broader therapeutic applications, including treatments cancer, rare genetic disorders, infectious diseases. also discusses emerging systems, such polymeric viral vectors, which offer alternative strategies overcome existing challenges related immune responses, tissue-specific targeting. Additionally, we examine pandemic's influence regulatory processes, fast-tracked approvals therapies, surge research funding that spurred further innovation field. Public acceptance grown, laying groundwork future developments personalized medicine. By providing an in-depth analysis these advancements, this highlights long-term evolution therapeutics precision drug technologies.

Language: Английский

Lipid nanoparticle-based strategies for extrahepatic delivery of nucleic acid therapies – challenges and opportunities DOI
Jens B. Simonsen

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 763 - 772

Published: May 17, 2024

Language: Английский

Citations

17
Advanced Polymeric Nanoparticles for Cancer Immunotherapy: Materials Engineering, Immunotherapeutic Mechanism and Clinical Translation DOI Open Access

Wencong Jia,

Ye Wu, Yujie Xie

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Cancer immunotherapy, which leverages immune system components to treat malignancies, has emerged as a cornerstone of contemporary therapeutic strategies. Yet, critical concerns about the efficacy and safety cancer immunotherapies remain formidable. Nanotechnology, especially polymeric nanoparticles (PNPs), offers unparalleled flexibility in manipulation‐from chemical composition physical properties precision control nanoassemblies. PNPs provide an optimal platform amplify potency minimize systematic toxicity broad spectrum immunotherapeutic modalities. In this comprehensive review, basics polymer chemistry, state‐of‐the‐art designs from physicochemical standpoint for encompassing vaccines, situ vaccination, adoptive T‐cell therapies, tumor‐infiltrating cell‐targeted antibodies, cytokine therapies are delineated. Each immunotherapy necessitates distinctively tailored design strategies nanoplatforms. The extensive applications PNPs, investigation their mechanisms action enhanced particularly focused on. profiles clinical research progress discussed. Additionally, forthcoming developments emergent trends nano‐immunotherapeutics poised transform treatment paradigms into clinics explored.

Language: Английский

Citations

2
A perspective on bleb and empty LNP structures DOI

Jens B Simonsen

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 373, P. 952 - 961

Published: Aug. 8, 2024

Language: Английский

Citations

12
Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy DOI
Jacob Witten, Idris O. Raji, Rajith S. Manan

et al.

Nature Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Language: Английский

Citations

11
A review of RNA nanoparticles for drug/gene/protein delivery in advanced therapies: Current state and future prospects DOI

Pegah Vosoughi,

Seyed Morteza Naghib, Babak Mikaeeli Kangarshahi

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139532 - 139532

Published: Jan. 5, 2025

Language: Английский

Citations

1
tRNA-derived small RNAs: their role in the mechanisms, biomarkers, and therapeutic strategies of colorectal cancer DOI Creative Commons
Bo Zhang, Yi Pan, Zhe Li

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 13, 2025

Colorectal cancer (CRC) is the third most prevalent malignancy and second leading cause of cancer-related mortality worldwide, with an increasing shift towards younger age onset. In recent years, there has been recognition significance tRNA-derived small RNAs (tsRNAs), encompassing fragments (tRFs) tRNA halves (tiRNAs). Their involvement in regulating translation, gene expression, reverse transcription, epigenetics gradually come to light. Emerging research revealed dysregulation tsRNAs CRC, implicating their role CRC initiation progression, highlighting potential early diagnosis, prognosis, therapeutic strategies. Although clinical application still its stages, findings highlight a close relationship between biogenesis function tsRNAs, chemical modifications, tumor immune microenvironment (TIME). Additionally, similar other RNAs, can be effectively delivered via nanoparticles (NPs). Consequently, future should focus on elucidating concerning base TIME regulation, immunotherapy, NPs delivery systems facilitate translation.

Language: Английский

Citations

1
In vivo production of engineered ACE2 decoy protects lungs from SARS-CoV-2 infection DOI Creative Commons
Yuta Suzuki,

Takayuki Miyazaki,

Yoko Ida

et al.

Molecular Therapy — Nucleic Acids, Journal Year: 2025, Volume and Issue: 36(1), P. 102467 - 102467

Published: Jan. 29, 2025

Language: Английский

Citations

1
Lung‐Specific mRNA Delivery by Ionizable Lipids with Defined Structure‐Function Relationship and Unique Protein Corona Feature DOI Creative Commons
Xiaoyan He, Rui Wang,

Yan Cao

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Targeted delivery of mRNA with lipid nanoparticles (LNPs) holds great potential for treating pulmonary diseases. However, the lack rational design principles efficient lung‐homing lipids hinders prevalence therapeutics in this organ. Herein, combinatorial screening structure‐function analysis is applied to rationalize strategy nonpermanently charged lung‐targeted ionizable lipids. It discovered that carrying N‐methyl and secondary amine groups heads, three tails originated from epoxyalkanes, exhibiting superior selectivity efficiency. Representative systematically variation chemical structures are selected study well‐known but still puzzling “protein corona” adsorbed on surface LNPs. In addition commonly used corona‐biomarker vitronectin, other arginine‐glycine‐aspartic acid (RGD)‐rich proteins usually involved collagen‐containing extracellular matrix, such as fibrinogen fibronectin have also been identified a strong correlation lung tropism. This work provides insight into lung‐targeting reveals previously unreported function RGD‐rich protein corona

Language: Английский

Citations

1
Biomimetic MOF Nanocarrier‐Mediated Synergistic Delivery of Mitochondria and Anti‐Inflammatory miRNA to Alleviate Acute Lung Injury DOI Creative Commons
Xin Shou, Changjiang Chen,

Hangjie Ying

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Abstract Acute lung injury (ALI) is a clinically critical disease characterized by overwhelming inflammatory response and significant tissue damage with no specific treatment available currently. As key player in the pathogenesis of ALI, macrophages are aberrantly activated polarize toward pro‐inflammatory phenotypes, leading to overzealous inflammation injury. Mitochondria recognized as crucial signaling hub governing macrophage function polarization, deregulation which causatively related defective metabolism macrophages, deregulated inflammation, hence ALI. Herein, an inflammation‐responsive, biomimetic metal‐organic framework (MOF) nanoplatform, termed a127/mito@ZIF@Ma developed, sophistically designed for synergistic delivery macrophage‐derived mitochondria anti‐inflammatory miRNA‐127 antagonist resume pulmonary homeostasis alleviate Notably, membrane encapsulation conferred MOF enhanced transport efficacy both vitro vivo. Therefore, administration nanoparticles accordingly profound protection mice against induced either bacterial or viral infection unnoticeable toxicity. The study thus devises novel MOF‐based nanosystem that integrates transplantation miRNA therapeutics, may open new avenue treating ALI relevant diseases.

Language: Английский

Citations

1
RNA delivery systems DOI Creative Commons
Sangeeta Bhatia, James E. Dahlman

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(11)

Published: March 4, 2024

Due to its small size and lifelong optical transparency, the fish Danionella cerebrum is an emerging model organism in biomedical research. How can this vertebrate under 12 mm length produce sounds over 140 dB? We found that it possesses ...Motion basis of nearly all animal behavior. Evolution has led some extraordinary specializations propulsion mechanisms among invertebrates, including mandibles dracula ant claw pistol shrimp. In contrast, ...

Language: Английский

Citations

6