Development and organization of the retinal orientation selectivity map
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июнь 6, 2024
Abstract
Orientation
or
axial
selectivity,
the
property
of
neurons
in
visual
system
to
respond
preferentially
certain
angles
stimuli,
plays
a
pivotal
role
our
understanding
perception
and
information
processing.
This
computation
is
performed
as
early
retina,
although
much
work
has
established
cellular
mechanisms
retinal
orientation
how
this
organized
across
retina
unknown.
Using
large
dataset
collected
mouse
we
demonstrate
functional
organization
rules
selectivity.
First,
identify
three
major
classes
cells
that
are
selective
match
previous
descriptions.
Second,
show
one
predominantly
represented
predominant
changes
function
location.
Third,
neural
activity
little
on
Lastly,
use
silico
modeling
followed
by
validation
experiments
overrepresented
aligns
along
concentric
axes.
These
results
that,
similar
direction
selectivity
map
retina.
Язык: Английский
Predation without direction selectivity
Proceedings of the National Academy of Sciences,
Год журнала:
2024,
Номер
121(12)
Опубликована: Март 14, 2024
Across
the
animal
kingdom,
visual
predation
relies
on
motion-sensing
neurons
in
superior
colliculus
(SC)
and
its
orthologs.
These
exhibit
complex
stimulus
preferences,
including
direction
selectivity,
which
is
thought
to
be
critical
for
tracking
unpredictable
escape
routes
of
prey.
The
source
selectivity
SC
contested,
contributions
have
not
been
tested
experimentally.
Here,
we
use
type-specific
cell
removal
show
that
narrow-field
(NF)
mouse
guide
predation.
In
vivo
recordings
demonstrate
direction-selective
responses
NF
cells
are
independent
recently
reported
stimulus-edge
effects.
Monosynaptic
retrograde
tracing
reveals
receive
synaptic
input
from
ganglion
cells.
When
eliminate
retina
adult
mice,
SC,
cells,
lost.
However,
eliminating
retinal
does
affect
hunting
success
or
strategies
even
when
removed
after
mice
learned
hunt,
despite
abolishing
gaze-stabilizing
optokinetic
reflex.
Thus,
our
results
identify
SC.
They
predation,
an
essential
spatial
orienting
task,
their
revealing
behavioral
multiplexing
neural
feature
preferences
highlighting
importance
feature-selective
manipulations
neuroethology.
Язык: Английский
Genetically defined neuron types underlying visuomotor transformation in the superior colliculus
Nature reviews. Neuroscience,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 27, 2024
Язык: Английский
Task-specific regional circuit adaptations in distinct mouse retinal ganglion cells
Science Advances,
Год журнала:
2025,
Номер
11(17)
Опубликована: Апрель 23, 2025
In
the
mouse
retina,
sustained
ON
alpha
(sONα)
retinal
ganglion
cells
(RGCs)
have
different
dendritic
and
receptive
field
sizes
along
nasotemporal
axis,
with
temporal
sONα
RGCs
likely
playing
a
role
in
visually
guided
hunting.
Thus,
we
hypothesized
that
this
cell
type
also
exhibits
regional
adaptations
signal
processing
these
are
advantageous
for
prey
capture.
Here,
measured
signals
from
individual
at
locations.
We
both
postsynaptic
Ca
2+
dendrites
presynaptic
glutamate
bipolar
(BCs).
found
exhibit,
addition
to
sustained-ON
only
weak
surrounds,
strong
surround
suppression,
which
were
not
present
nasal
RGCs.
This
difference
was
inputs
BCs.
Last,
using
population
models
an
encoder-decoder
paradigm,
showed
might
be
beneficial
detecting
crickets
hunting
behavior.
Язык: Английский
Development and Organization of the Retinal Orientation Selectivity Map
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 28, 2024
Abstract
Orientation
or
axial
selectivity,
the
property
of
neurons
in
visual
system
to
respond
preferentially
certain
angles
a
stimuli,
plays
pivotal
role
our
understanding
perception
and
information
processing.
This
computation
is
performed
as
early
retina,
although
much
work
has
established
cellular
mechanisms
retinal
orientation
how
this
organized
across
retina
unknown.
Using
large
dataset
collected
mouse
we
demonstrate
functional
organization
rules
selectivity.
First,
identify
three
major
classes
cells
that
are
selective
match
previous
descriptions.
Second,
show
one
predominantly
represented
predominant
changes
function
location.
Third,
neural
activity
little
on
Lastly,
use
silico
modeling
followed
by
validation
experiments
overrepresented
aligns
along
concentric
axes.
These
results
that,
similar
direction
selectivity
map
retina.
One
Sentence
Summary
Development
Язык: Английский
Sustained ON alpha retinal ganglion cells in the temporal retina exhibit task-specific regional adaptions in dendritic signal integration
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 29, 2024
Various
retinal
ganglion
cells
(RGCs)
show
regional
adaptations,
for
instance,
to
increase
visual
acuity.
However,
many
RGC
types,
it
is
not
known
how
they
vary
in
their
signalprocessing
properties
across
the
retina.
In
mouse
retina,
sustained
ON
alpha
(sONα)
RGCs
were
found
have
differences
morphology
and
receptive
field
sizes
along
nasotemporal
axis,
temporal
sONα
are
likely
play
a
role
visually
guided
hunting.
Thus,
we
hypothesised
that
this
cell
type
also
exhibits
adaptations
on
level
of
dendritic
signal
processing
these
advantageous
prey
capture.
Here,
measured
signals
from
individual
at
different
locations
exvivo
whole-mount
retina
using
two-photon
microscopy.
We
both
postsynaptic
Ca
2+
dendrites
presynaptic
glutamate
bipolar
(BCs).
exhibit,
addition
expected
sustained-ON
with
only
weak
surrounds,
strong
surround
suppression,
which
present
nasal
RGCs.
This
difference
was
excitatory
inputs
BCs,
suggesting
origin.
Finally,
population
models
an
encoder-decoder
paradigm,
showed
might
be
beneficial
detecting
crickets
hunting
behaviour.
Язык: Английский