Predation without direction selectivity

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(12)

Published: March 14, 2024

Across the animal kingdom, visual predation relies on motion-sensing neurons in superior colliculus (SC) and its orthologs. These exhibit complex stimulus preferences, including direction selectivity, which is thought to be critical for tracking unpredictable escape routes of prey. The source selectivity SC contested, contributions have not been tested experimentally. Here, we use type-specific cell removal show that narrow-field (NF) mouse guide predation. In vivo recordings demonstrate direction-selective responses NF cells are independent recently reported stimulus-edge effects. Monosynaptic retrograde tracing reveals receive synaptic input from ganglion cells. When eliminate retina adult mice, SC, cells, lost. However, eliminating retinal does affect hunting success or strategies even when removed after mice learned hunt, despite abolishing gaze-stabilizing optokinetic reflex. Thus, our results identify SC. They predation, an essential spatial orienting task, their revealing behavioral multiplexing neural feature preferences highlighting importance feature-selective manipulations neuroethology.

Language: Английский

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Development and organization of the retinal orientation selectivity map

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 6, 2024

Abstract Orientation or axial selectivity, the property of neurons in visual system to respond preferentially certain angles stimuli, plays a pivotal role our understanding perception and information processing. This computation is performed as early retina, although much work has established cellular mechanisms retinal orientation how this organized across retina unknown. Using large dataset collected mouse we demonstrate functional organization rules selectivity. First, identify three major classes cells that are selective match previous descriptions. Second, show one predominantly represented predominant changes function location. Third, neural activity little on Lastly, use silico modeling followed by validation experiments overrepresented aligns along concentric axes. These results that, similar direction selectivity map retina.

Language: Английский

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Genetically defined neuron types underlying visuomotor transformation in the superior colliculus

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Language: Английский

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Task-specific regional circuit adaptations in distinct mouse retinal ganglion cells

Science Advances, Journal Year: 2025, Volume and Issue: 11(17)

Published: April 23, 2025

In the mouse retina, sustained ON alpha (sONα) retinal ganglion cells (RGCs) have different dendritic and receptive field sizes along nasotemporal axis, with temporal sONα RGCs likely playing a role in visually guided hunting. Thus, we hypothesized that this cell type also exhibits regional adaptations signal processing these are advantageous for prey capture. Here, measured signals from individual at locations. We both postsynaptic Ca 2+ dendrites presynaptic glutamate bipolar (BCs). found exhibit, addition to sustained-ON only weak surrounds, strong surround suppression, which were not present nasal RGCs. This difference was inputs BCs. Last, using population models an encoder-decoder paradigm, showed might be beneficial detecting crickets hunting behavior.

Language: Английский

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Sustained ON alpha retinal ganglion cells in the temporal retina exhibit task-specific regional adaptions in dendritic signal integration

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 29, 2024

Various retinal ganglion cells (RGCs) show regional adaptations, for instance, to increase visual acuity. However, many RGC types, it is not known how they vary in their signalprocessing properties across the retina. In mouse retina, sustained ON alpha (sONα) RGCs were found have differences morphology and receptive field sizes along nasotemporal axis, temporal sONα are likely play a role visually guided hunting. Thus, we hypothesised that this cell type also exhibits adaptations on level of dendritic signal processing these advantageous prey capture. Here, measured signals from individual at different locations exvivo whole-mount retina using two-photon microscopy. We both postsynaptic Ca 2+ dendrites presynaptic glutamate bipolar (BCs). exhibit, addition expected sustained-ON with only weak surrounds, strong surround suppression, which present nasal RGCs. This difference was excitatory inputs BCs, suggesting origin. Finally, population models an encoder-decoder paradigm, showed might be beneficial detecting crickets hunting behaviour.

Language: Английский

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Development and Organization of the Retinal Orientation Selectivity Map

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 28, 2024

Abstract Orientation or axial selectivity, the property of neurons in visual system to respond preferentially certain angles a stimuli, plays pivotal role our understanding perception and information processing. This computation is performed as early retina, although much work has established cellular mechanisms retinal orientation how this organized across retina unknown. Using large dataset collected mouse we demonstrate functional organization rules selectivity. First, identify three major classes cells that are selective match previous descriptions. Second, show one predominantly represented predominant changes function location. Third, neural activity little on Lastly, use silico modeling followed by validation experiments overrepresented aligns along concentric axes. These results that, similar direction selectivity map retina. One Sentence Summary Development

Language: Английский

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