Targeting of TAMs: can we be more clever than cancer cells?
Cellular and Molecular Immunology,
Год журнала:
2024,
Номер
21(12), С. 1376 - 1409
Опубликована: Ноя. 8, 2024
АBSTRACT:
With
increasing
incidence
and
geography,
cancer
is
one
of
the
leading
causes
death,
reduced
quality
life
disability
worldwide.
Principal
progress
in
development
new
anticancer
therapies,
improving
efficiency
immunotherapeutic
tools,
personification
conventional
therapies
needs
to
consider
cancer-specific
patient-specific
programming
innate
immunity.
Intratumoral
TAMs
their
precursors,
resident
macrophages
monocytes,
are
principal
regulators
tumor
progression
therapy
resistance.
Our
review
summarizes
accumulated
evidence
for
subpopulations
number
biomarkers,
indicating
predictive
value
clinical
parameters
carcinogenesis
resistance,
with
a
focus
on
solid
cancers
non-infectious
etiology.
We
present
state-of-the-art
knowledge
about
tumor-supporting
functions
at
all
stages
highlight
recently
identified
by
single-cell
spatial
analytical
methods,
that
discriminate
between
tumor-promoting
tumor-inhibiting
TAMs,
where
both
subtypes
express
combination
prototype
M1
M2
genes.
focuses
novel
mechanisms
involved
crosstalk
among
epigenetic,
signaling,
transcriptional
metabolic
pathways
TAMs.
Particular
attention
has
been
given
link
cell
metabolism
epigenetic
histone
lactylation,
which
can
be
responsible
unlimited
protumoral
Finally,
we
explain
how
interfere
currently
used
therapeutics
summarize
most
advanced
data
from
trials,
divide
into
four
categories:
inhibition
TAM
survival
differentiation,
monocyte/TAM
recruitment
tumors,
functional
reprogramming
genetic
enhancement
macrophages.
Язык: Английский
Single-cell and spatial transcriptomic profiling revealed niche interactions sustaining growth of endometriotic lesions
Cell Genomics,
Год журнала:
2025,
Номер
5(1), С. 100737 - 100737
Опубликована: Янв. 1, 2025
Highlights•Single-cell
and
spatial
data
reveal
hierarchical
microenvironment
in
endometriomas•Ectopic
endometrial
stromal
cells
retain
menstrual
cycle
gene
expression
patterns•Distinct
ovarian
(OSCs)
links
to
fibrosis
inflammation
lesions•WNT5A
signaling
mediates
interactions
between
ectopic
OSCsSummaryEndometriosis
is
a
chronic
condition
with
limited
therapeutic
options.
The
molecular
aberrations
promoting
attachment
the
local
sustaining
lesion
growth
have
been
unclear,
prohibiting
development
of
targeted
therapies.
Here,
we
performed
single-cell
transcriptomic
profiling
lesions
eutopic
endometrium
endometriosis.
We
found
that
(EnS)
retained
cyclical
patterns
their
counterparts
while
exhibiting
unique
contributes
pathogenesis
identified
two
distinct
localized
at
different
zones
lesion,
showing
differential
profiles
associated
inflammation,
respectively.
also
WNT5A
upregulation
aberrant
activation
non-canonical
WNT
may
contribute
establishment,
offering
novel
targets
for
intervention.
These
will
enhance
our
understanding
mechanisms
underlying
endometriosis
paves
way
developing
non-hormonal
treatments.Graphical
abstract
Язык: Английский
Update on the pathogenesis of endometriosis-related infertility based on contemporary evidence
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Март 10, 2025
Endometriosis,
the
most
prevalent
cause
of
infertility,
is
associated
with
anatomical
distortion
leading
to
adhesions
and
fibrosis,
as
well
endocrine
abnormalities
immune
disorders.
This
review
discusses
mechanisms
underlying
endometriosis-related
infertility.
Firstly,
alterations
in
hypothalamic-pituitary-ovarian
axis
lead
secretion
gonadotropins
steroid
hormones,
adverse
effects
on
ovulation
implantation,
fertility
decline.
Secondly,
dysregulation
hypothalamic-pituitary-adrenal
induces
elevated
serum
cortisol
prolactin
levels
patients
endometriosis,
accounting
for
its
regulation
stress,
depression,
anxiety.
Abnormal
interactions
between
endometrial
cells
system
change
local
microenvironment,
resulting
epithelial-mesenchymal
transition
inflammation.
Activated
epithelial
cells,
stromal
immunocytes
produce
various
chemokines,
cytokines,
or
autoantibodies,
creating
an
unfavorable
environment
embryo
implantation.
These
findings
suggest
that
spectrum
play
a
crucial
role
Thirdly,
oxidative
stress
has
ovarian
reserve
subsequent
embryonic
development,
predicting
another
promising
strategy
An
unbalanced
redox
state,
including
impaired
mitochondrial
function,
dysregulated
lipid
metabolism,
iron-induced
generates
pro-oxidative
which
negatively
impacts
oocyte
quality
sperm
viability.
Thus,
updated
understanding
involved
this
disease
will
help
develop
effective
strategies
manage
Язык: Английский
TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 19, 2025
Язык: Английский
Oleanolic acid inhibits M2 macrophage polarization and potentiates anti-PD-1 therapy in hepatocellular carcinoma by targeting miR-130b-3p-PTEN-PI3K-AKT signaling and glycolysis
Phytomedicine,
Год журнала:
2025,
Номер
unknown, С. 156750 - 156750
Опубликована: Апрель 1, 2025
Язык: Английский
Single-cell and spatial transcriptomics reveal the pathogenesis of chronic granulomatous disease in a natural model
Cell Reports,
Год журнала:
2025,
Номер
44(5), С. 115612 - 115612
Опубликована: Апрель 22, 2025
Язык: Английский
Endometriosis: An Immunologist’s Perspective
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(11), С. 5193 - 5193
Опубликована: Май 28, 2025
Endometriosis,
a
complex
inflammatory
disease,
affects
significant
proportion
of
women
reproductive
age,
approximately
10–15%.
The
disease
involves
the
growth
endometrial
glands
and
stroma
outside
uterine
cavity,
leading
to
tissue
remodeling
fibrosis.
Hormonal
imbalances,
accompanied
by
local
general
inflammation
pain,
are
key
features
endometriosis.
Endometriotic
lesions
associated
with
overproduction
cytokines,
metalloproteinases,
prostaglandins,
reactive
oxygen
radicals,
extracellular
vesicles.
Genetic
predisposition
cytokine
gene
polymorphisms
have
been
documented.
Macrophages,
dendritic
cells,
mast
Th1
in
early
phase,
Th2
late
T
regulatory
cells
play
crucial
role
Reduced
NK
cell
function
impaired
immune
vigilance
contribute
growth.
strong
condition
endometrium
poses
barrier
proper
implantation
zygote,
contributing
infertility
these
patients.
Cytokines
from
various
types
vary
severity
disease.
microbiota
endometriosis
is
still
under
study.
Endometriosis
autoimmunity
ovarian
cancer.
treatments
surgery
commonly
used;
however,
recent
interest
focuses
on
anti-inflammatory
immunomodulatory
therapies,
including
anti-cytokine
antibodies.
Modulating
response
has
proven
critical;
more
research
needed
optimize
treatment
for
Язык: Английский
RNA sequencing reveals novel molecular mechanisms of endometriosis lesion development in a mouse model
Disease Models & Mechanisms,
Год журнала:
2024,
Номер
17(10)
Опубликована: Окт. 1, 2024
ABSTRACT
Understanding
of
molecular
mechanisms
contributing
to
the
pathophysiology
endometriosis,
and
upstream
drivers
lesion
formation,
remains
limited.
Using
a
C57Bl/6
mouse
model
in
which
decidualized
endometrial
tissue
is
injected
subcutaneously
abdomen
recipient
mice,
we
generated
comprehensive
profile
gene
expression
(n=4),
endometriosis-like
lesions
at
Day
7
(n=4)
14
formation.
High-throughput
mRNA
sequencing
allowed
identification
genes
pathways
involved
initiation
progression
lesions.
We
observed
distinct
patterns
with
substantial
differences
between
endometrium
that
remained
stable
across
two
timepoints,
showed
similarity
transcriptional
changes
implicated
human
endometriosis
Pathway
enrichment
analysis
revealed
several
immune
inflammatory
response-associated
canonical
pathways,
multiple
potential
regulators,
involvement
not
previously
pathogenesis,
including
IRF2BP2
ZBTB10,
suggesting
novel
roles
disease
progression.
Collectively,
provided
data
will
be
useful
resource
inform
research
on
development
this
model.
Язык: Английский
Editorial: Participant characteristics and biological markers for endometriosis diagnosis or prediction of treatment response
Frontiers in Reproductive Health,
Год журнала:
2024,
Номер
6
Опубликована: Дек. 19, 2024
and
is
associated
with
a
range
of
symptoms,
most
commonly
debilitating
pelvic
pain
infertility
[1].Standard
practice
for
definitive
endometriosis
diagnosis
has
been
through
surgical
visualization
lesions.
However,
increasingly
imaging
being
used
to
inform
symptom
management
strategies
certain
subtypes,
particularly
when
fertility
treatment
planned
[1].
The
invasive
nature
leads,
in
part,
the
average
7-year
delay
between
onset
[2].
Once
person
diagnosed
endometriosis,
conventional
treatments
include
use
hormonal
medications
suppress
ovulation
removal
endometriotic
lesions
[1].Adding
complexity
diagnostic
delays
potential
need
additional
surgeries,
extensive
heterogeneity
presentation
lesion
characteristics
[1].Endometriosis
vary
color,
size,
location,
histopathologic
metabolic
characteristics,
which
may
have
important
implications
options.
For
example,
recent
review
highlighted
impact
fibrosis
within
lesions,
represent
future
therapeutic
target
[3].
Lesions
more
had
higher
numbers
nerve
cells,
be
linked
increased
symptoms
Other
studies
suggested
macrophages
altered
phenotypes
found
are
basis
recently
launched
clinical
trial
[TCS/23/19,
MacEndo]
[4].
further
work
needed
expand
on
trials
based
targeting
full
evaluation
their
both
symptoms.
Additionally,
there
does
not
exist
valid
tool
sufficient
sensitivity
specificity
replace
or
triage
laparoscopic
surgery.
Further,
no
biological
markers
algorithms
determining
patients
will
experience
recurrent
not.The
aim
this
research
topic
was
our
understanding
how
that
biomarkers
and/or
response.Incorporating
informative
disease
into
biomarker
analyses
critical
obtaining
results
[5].
Two
papers
investigated
among
participants
analyses.
Although
peritoneal
fluid
often
identify
terms
color
volume
relation
patient
fully
[6,7].
Yousif
et
al
(2023)
participant
differ
by
545
who
enrolled
Women's
Health
Study:
from
Adolescence
Adulthood
cohort
study
[8].
authors
varied
menstrual
cycle
phase,
medication
use,
presence
acyclic
pain.
appeared
hormone
pain.These
suggest
accounting
phase
utilizing
discovery.Additionally,
last
5
years
increasing
interest
microRNAs
(miRNAs),
small
non-coding
RNAs
involved
epigenetic
gene
regulation,
as
[9],
some
potentially
promising
claimed
saliva
an
accessible
biofluid
[10].
In
special
issue,
Brady
(2024)
miRNAs
blood
samples
during
adolescence
young
adulthood
measurements
discovery
(10
cases
10
controls)
internal
replication
(54
108
group.
During
49
were
differentially
expressed
controls.
study,
miRNA
score
miR-545-3p,
let-7b-3p,
miR-548i,
miR-769-5p,
miR-30c-1-3p
area
under
curve
(AUC)
0.77
(95%
confidence
intervals:
0.67-0.87).
While
sufficiently
sensitive
specific
enough
tool,
noted
expression
without
differed
use.
These
it
account
miRNAs,
vast
majority
prior
diagnosis.An
component
furthering
investigating
new
describe
differences
subtypes
support
development
personalized
approaches
therapy.
To
address
challenge,
Zoet
developed
standardized
protocol
assess
bundle
density
236
tissue
121
patients.
novel
protocol,
calculated
number
bundles
immunopositive
PGP9.5
divided
surface
area.
observed
excellent
intra-and
inter-observer
reliability
importantly
subtype.
Higher
deep
superficial
compared
endometriomas.
findings
useful
local
neurogenesis
advance
differs
impacts
pathogenesis
response
disease.Finally,
up
94%
report
complementary
alternative
methods
coping
endometriosis-associated
[11],
includes
growing
dietary
modification
[12].
known
effectiveness
these
age
group
past
focused
largely
adults
confirmed
diagnosis.
gap
knowledge,
Mongiovi
explored
adolescents
(age
<18;
n=137),
18-24;
n=143),
≥25;
n=77).
They
likely
sleeping
(57%)
listening
music
(21%)
helped
(44%
7%,
respectively)
(43%
9%,
respectively).
Conversely,
(11%)
(15%)
yoga
improved
(4%).
exercise
decrease
age,
60%
adolescents,
47%
adults,
35%
reporting
made
worse.
highlight
developing
plans
incorporate
while
taking
accessibility
acceptability
approaches.The
included
acceptability.
offer
resource
considering
design
research.
Reflecting
greater
appreciation
cancer
revolutionized
knowledge
options
cancers
such
breast
[13],
we
believe
increase
data
related
vastly
pathophysiology
well
aiding
diagnostics
Язык: Английский
Geneticsbiologiesingle cell and expression analysis for erectile dysfunction and cervical cancer targets
Discover Oncology,
Год журнала:
2024,
Номер
15(1)
Опубликована: Дек. 21, 2024
Sexual
dysfunction
and
cervical
cancer
are
genetically
molecularly
two
complex
health
problems.
Here,
we
integrate
genetic
inference
single-cell
expression
analysis
to
identify
potential
targets
for
sexual
cancer,
assess
causality
of
these
utilizing
Mendelian
randomization
approaches.
We
performed
a
genome-wide
association
study
(GWAS)
variants
associated
with
cancer.
Next,
examined
the
cellular
landscape
variation
regions
based
on
scRNAseq
data.
The
identified
several
that
correlated
respectively,
differentially
expressed
in
reproductive
cells.
Two-Gene
Combination
Panel
Increased
WISP1
gene
was
detected
tissues.
Twas
most
highly
T
cells,
least
well-
when
cells
were
proliferating.
integrates
genetics
nominate
establishes
causal
support
from
approach.
Язык: Английский