Seminars in Interventional Radiology,
Год журнала:
2023,
Номер
40(06), С. 497 - 504
Опубликована: Дек. 1, 2023
Abstract
Cancer
has
and
continues
to
be
a
complex
health
crisis
plaguing
millions
around
the
world.
Alcohol
ablation
was
one
of
initial
methods
used
for
treatment
liver
lesions.
It
surpassed
by
thermal
which
played
big
role
in
therapeutic
arsenal
primary
metastatic
tumors.
However,
several
shortcomings
limitations
that
prompted
development
alternative
technologies
including
electroporation
histotripsy.
Percutaneous
alcohol
injection
lesion
leads
dehydration
coagulative
necrosis.
This
technology
is
limited
with
relative
sparing
surrounding
tissue,
making
it
safe
use
adjacent
sensitive
structures.
Electroporation
utilizes
short
high-voltage
pulses
permeabilize
cell
membrane
can
result
death
dependent
on
threshold
reached.
effectively
target
tumor
margins
lower
damage
rates
structures
due
pulse
duration.
Histotripsy
novel
technology,
although
first
human
trial
just
completed,
its
results
are
encouraging,
given
sharp
demarcation
targeted
lack
damage,
potential
immunomodulation
microenvironment.
Herein,
we
discuss
these
techniques,
their
uses,
overall
clinical
benefit.
Integrative Cancer Therapies,
Год журнала:
2024,
Номер
23
Опубликована: Янв. 1, 2024
Hyperthermia,
the
raising
of
tumor
temperature
(≥39°C),
holds
great
promise
as
an
adjuvant
treatment
for
cancer
therapy.
This
review
focuses
on
2
key
aspects
hyperthermia:
its
molecular
and
cellular
effects
impact
immune
system.
Hyperthermia
has
profound
critical
biological
processes.
Increased
temperatures
inhibit
DNA
repair
enzymes,
making
cells
more
sensitive
to
chemotherapy
radiation.
Elevated
also
induce
cell
cycle
arrest
trigger
apoptotic
pathways.
Furthermore,
hyperthermia
modifies
expression
heat
shock
proteins,
which
play
vital
roles
in
therapy,
including
enhancing
responses.
Hyperthermic
treatments
have
a
significant
body’s
response
against
tumors,
potentially
improving
efficacy
checkpoint
inhibitors.
Mild
systemic
(39°C-41°C)
mimics
fever,
activating
metabolic
rates.
Intense
above
50°C
can
release
antigens,
reactions.
Using
photothermal
nanoparticles
targeted
heating
drug
delivery
modulate
response.
emerges
cost-effective
well-tolerated
therapy
when
integrated
with
immunotherapy.
comprehensive
serves
valuable
resource
selection
patient-specific
guidance
future
experimental
studies.
Cells,
Год журнала:
2025,
Номер
14(3), С. 166 - 166
Опубликована: Янв. 22, 2025
Colorectal
cancer
(CRC)
remains
one
of
the
leading
causes
cancer-related
morbidity
and
mortality
around
world.
Despite
advances
in
surgery,
chemotherapy,
targeted
therapies,
prognosis
for
patients
with
metastatic
or
advanced
CRC
poor.
Immunotherapies
comprising
immune
checkpoint
inhibitors
showed
disappointing
responses
(mCRC).
However,
cellular
immunotherapy,
specifically
using
classical
dendritic
cells
(cDCs),
may
hold
unique
promise
recognition
antigens.
cDCs
are
substantial
players
instrumental
orchestrating
innate
adaptive
by
processing
presenting
tumor
antigens
to
effector
cells.
Natural
killer
T
(NKT)
insufficiently
studied
but
because
their
ability
bridge
reactions
crosstalk
cancer.
This
review
explores
therapeutic
potential
both
NKT
as
a
synergistic
therapy
CRC,
focusing
on
biological
roles,
strategies
harnessing
capabilities,
clinical
applications,
challenges
within
microenvironment.
Both
can
be
used
new
effective
approach
cell-based
therapies
cancers
provide
hope
that
challenging
treat.
International Journal of Hyperthermia,
Год журнала:
2025,
Номер
42(1)
Опубликована: Янв. 22, 2025
Purpose
In
magnetic
resonance-guided
focused
ultrasound
(MRgFUS)
breast
therapies,
the
focal
location
must
be
characterized
to
guide
successful
treatment.
Focal
characterization
is
difficult
because
heterogeneous
tissues
introduce
phase
aberrations
that
blur
and
shift
focus
traditional
guidance
methods
do
not
work
in
adipose
tissues.
The
purpose
of
this
evaluate
numerical
simulations
MRgFUS
predict
location.
Those
are
compared
clinical
resonance
acoustic
radiation
force
imaging
(MR-ARFI)
data
collected
during
vivo
treatment
tumors.
Immune
checkpoint
inhibitors
hold
promise,
yet
their
efficacy
in
solid
tumors
is
limited
by
the
complex
tumor
microenvironment
and
lack
of
immune
cell
infiltration.
This
study
aims
to
enhance
immunotherapy
combining
anti
PD-1
inhibition
therapy
with
nanodroplet-mediated
histotripsy.
The
proposed
method
involves
systemic
injection
nanodroplets,
which
accumulate
within
tumors.
These
nanodroplets
are
then
activated
into
cavitating
gas
bubbles
using
a
rotating
imaging
probe,
followed
low-frequency
ultrasound
application.
process
induces
fractionation,
facilitating
shift
from
cold
hot.
Tumor
ablation
results
show
extensive
lesions
cancerous
tissues,
demonstrating
effectiveness
treatment.
combined
approach
yielded
significant
reduction
growth
compared
control
groups.
Immunohistochemistry
analysis
reveals
an
increase
F4/80+
macrophages
CD8+
T
cells
treated
group,
indicating
enhanced
response.
reached
21.36%
±
3.4%,
while
T-cell
recruitment
achieved
6.76%
4.5%,
representing
6.8-
5.5-fold
respectively.
demonstrates
potential
overcome
key
barriers
treatment
precise
mechanical
disruption
activation.
Applied Physics Reviews,
Год журнала:
2024,
Номер
11(2)
Опубликована: Май 30, 2024
Physical
approaches
based
on
irradiation
provide
advances
for
the
prevention
and
treatment
of
viral
infections,
while
recognizing
that
certain
chemical
inactivation
techniques
demonstrate
significant
effectiveness
alongside
physical
methods.
By
generating
resonant
vibrations
complete
virus
particles,
which
are
in
GHz
range
quite
high
compared
to
human
cells,
viruses
can
be
inactivated.
Therefore,
exposure
ultrasound
waves
or
non-thermal
microwaves
with
a
suitable
frequency
oscillating
electric
field
holds
potential
neutralize
particle
no
damage
human.
The
deactivation
mechanism
could
result
mechanical
effect
oxidation
stress,
this
article,
we
discuss
elucidation
these
effects
virus'
structure.
We
also
explore
current
state
future
prospects
anti-viral
methods
acoustic
cavitation
via
microwave,
addressing
critical
needs
virology.
Annals of Biomedical Engineering,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 30, 2024
Glioblastoma
(GBM)
is
the
most
common
and
malignant
type
of
primary
brain
tumor.
Even
after
surgery
chemoradiotherapy,
residual
GBM
cells
can
infiltrate
healthy
parenchyma
to
form
secondary
tumors.
To
mitigate
recurrence,
we
recently
developed
an
injectable
hydrogel
that
be
crosslinked
in
resection
cavity
attract,
collect,
ablate
cells.
We
previously
optimized
a
thiol-Michael
addition
for
physical,
chemical,
biological
compatibility
with
microenvironment
demonstrated
CXCL12-mediated
chemotaxis
attract
entrap
into
this
hydrogel.
In
study,
synthesize
hydrogels
under
conditions
mimicking
cavities
assess
feasibility
histotripsy
hydrogel-encapsulated
The
results
showed
synthesis
was
bio-orthogonal,
not
shear-thinning,
scaled
up
injection
mimics
vitro.
Experiments
also
ultrasound
imaging
distinguish
synthetic
from
porcine
tissue.
Finally,
500
kHz
transducer
applied
focused
treatment
hydrogels,
demonstrating
precise
bubble
clouds
could
sustained
order
uniformly
red
blood
encapsulated
by
homogeneous,
mechanical
fractionation
entrapped
Overall,
promising
platform
biomaterials-based
treatment.
Technology in Cancer Research & Treatment,
Год журнала:
2024,
Номер
23
Опубликована: Янв. 1, 2024
Objective
Brain
tumors
represent
some
of
the
most
treatment
refractory
cancers,
and
there
is
a
clinical
need
for
additional
treatments
these
tumors.
Domesticated
dogs
are
only
other
mammalian
species
which
commonly
develop
spontaneous
brain
tumors,
making
them
an
ideal
model
investigating
novel
therapies.
Histotripsy
non-thermal
ultrasonic
ablation
method
that
emulsifies
tissue
through
acoustic
cavitation.
The
primary
objectives
this
prospective
study
were
to
assess
feasibility
safety
histotripsy
ablate
naturally
occurring
canine
Secondary
endpoints
included
characterization
magnetic
resonance
imaging
(MRI)
responses
treatment,
exploratory
immunogenomic
tumor
response
analyses.
Methods
design
utilized
treat
resect
paradigm,
where
approached
using
craniotomy,
partially
ablated
with
delivered
cranial
defect,
imaged
MRI,
then
resected.
Dogs
evaluated
clinical,
immunopathologic,
genomic
examinations
before
intraoperatively,
1,
14,
42
days
post-treatment.
Here
we
report
results
three
meningiomas,
all
treated
custom
eight
element
1
MHz
transducer
at
pulse
repetition
frequency
100
Hz
dosage
400
pulses/point.
Results
was
successfully
dogs,
resulting
in
histopathologic
evidence
ablations
sharply
demarcated
from
untreated
tumor,
measured
approximating
planned
volumes
2/3
dogs.
One
dog
experienced
adverse
event
consisting
transient
cerebral
edema
possibly
attributable
histotripsy.
could
be
grossly
visualized
identified
on
features
consistent
hemorrhage
necrosis.
Significant
expression
or
upregulation
damage
associated
molecular
pattern
HMGB1,
cytokine-cytokine
receptor
interaction,
NF-κb
signaling
pathways
observed
Conclusion
Ablation
meningiomas
open
window
feasible
clinically
well
tolerated.
