Plants
have
been
used
for
the
treatment
of
various
cancers
since
ancient
times.
Breast
cancer
is
second
commonest
global
deadly
menace.
Natural
plant
extracts,
herbal
medicines,
are
generally
accepted
as
safer
drug
substances
than
their
synthetic
counterparts.
Artemisia
absinthium,
a
perennial
bushy
plant,
has
traditionally
beneficial
in
diverse
maladies,
including
hepatocyte
overgrowth,
hepatitis,
gastritis,
jaundice,
wound
healing,
splenomegaly,
dyspepsia,
indigestion,
bloating,
stomach
pain,
anaemia
and
anorexia.
It
also
known
its
antioxidant,
antifungal,
antimicrobial,
anthelmintic,
anti-ulcer,
anticarcinogenic,
hepatoprotective,
neuroprotective,
antidepressant,
analgesic,
immunomodulatory,
cytotoxic
properties.
In
this
study,
methanol
extracts
powdered
leaves
absinthium
was
tried
on
breast
cells.
The
molecular
content
extract
determined
by
GC-MS.
Chemical
components
were
determinated
extract,
inhibitory
activities
these
chemicals
against
Crystal
structure
protein
(PDB
ID:
1A52
1JNX)
downloaded
from
Protein
Data
Bank
site
compared.
TURKISH JOURNAL OF CHEMISTRY,
Год журнала:
2024,
Номер
48(2), С. 402 - 421
Опубликована: Апрель 25, 2024
This
research
aimed
to
identify
potential
drug
compounds
from
the
ZINC15
molecule
database
that
could
effectively
treat
GnRH1R-related
diseases.
The
study
utilized
molecular
docking
and
dynamics
methods
achieve
this
goal,
which
is
crucial
in
repurposing
research.
virtual
screening
process
involved
analyzing
known
using
docking.
Additionally,
simulations
MM-GBSA
were
employed
evaluate
stability
of
complexes
determine
interactions
between
protein
structure.
As
a
result,
provides
significant
insights
for
treating
diseases
such
as
endometriosis,
uterine
fibroids,
prostate
cancer
related
GnRH1R.
also
designing
new
drugs
identifying
necessary
scaffolds.
Zeitschrift für Naturforschung C,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Abstract
A
new
series
of
hydrazone
derivatives
(
1a-1l
)
were
prepared
from
a
condensation
reaction
between
different
hydrazide
and
3-formylbenzoic
acid.
Through
the
use
several
spectral
techniques,
such
as
1
H-NMR,
13
C-NMR,
elemental
analysis,
structures
compounds
clarified.
The
crystal
structure
compound
1d
was
obtained
by
single-crystal
X-ray
crystallography.
They
found
to
have
inhibitory
effects
on
anticancer
potentials
human
carbonic
anhydrase
isoforms
I
II.
Compound
be
strongest
inhibitor,
with
IC
50
values
0.133
µM
against
hCA
I.
Also,
1l
showed
highest
activity
3.244
Moreover,
their
cytotoxic
rat
glioma
cell
colon
adeno
carcinoma
lines
evaluated.
According
cytotoxicity
results,
1j
exhibited
HT29
cell,
while
1e
,
1g,
effect
C6
line.
which
carries
methoxy
substituent
at
3
rd
position
phenyl
ring,
effective
both
cancer
cells
ADME/T
properties
molecular
docking
molecules
examined.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Май 21, 2024
Introduction
Cubeb,
Piper
cubeba
L.,
has
been
used
for
centuries
in
traditional
medicine
and
culinary
practices,
with
a
wide
range
of
biological
pharmacological
activities.
Objective
Herein,
we
determined
the
phytochemical
profile,
mineral,
fatty
acids,
amino
acid
contents
P.
berries
assessed
dermacosmeceutical
properties
their
water
extract
essential
oil
(EO).
These
included
assessing
antioxidant
antibacterial
activities
as
well
vitro
inhibitory
against
tyrosinase
elastase
enzymes.
In
addition,
molecular
docking
dynamics
studies
were
performed
on
major
identified
compounds
EO.
Results
discussion
A
total
forty-three
belonging
to
organic
phenolic
acids
flavonoids
found
extract,
while
36
volatile
EO
Z-isoeugenol,
dihydroeugenol,
β-pinene,
E-caryophyllene,
1,8-cineole
constituents.
The
be
rich
sodium
iron,
have
moderate
zinc
content
along
low
nitrogen,
phosphorus,
potassium.
Amino
analysis
revealed
considerable
concentration
isoleucine
phenylalanine,
whereas
11,14,17-eicosatrienoic
linoleic
acids.
DPPH
FRAP
assays,
elicited
activity
compared
reference
compounds.
Enzyme
assays
that
had
potential
inhibit
enzymes
IC
50
values
340.56
86.04
μg/mL,
respectively.
completely
inhibited
bacterial
growth
at
MIC
mg/mL
20%,
At
sub-MIC
concentrations,
substantially
reduced
biofilm
formation
by
up
26.63
77.77%,
respectively,
swimming
swarming
motilities
dose-dependent
manner.
Molecular
showed
five
main
components
could
contributors
effect.
Conclusion
This
study
emphasizes
promising
valuable
source
natural
can
utilized
development
innovative
pharmaceuticals,
dietary
supplements,
agents.
Polycyclic aromatic compounds,
Год журнала:
2024,
Номер
unknown, С. 1 - 19
Опубликована: Окт. 7, 2024
Hypopharyngeal
cancer
is
rare
subtype
of
head
and
neck
cancers
with
relatively
poor
prognosis.
Current
therapeutic
modalities
lack
the
potential
to
provide
patients
better
clinical
outcome
quality
life.
This
study
was
conducted
on
synthesis
2-methoxy-4-((3-alkyl(aryl)-5-oxo-1H-1,2,4-triazol-4(5H)-ylimino)-methyl)-phenyl-4-(2-methoxy-4-((3-alkyl(aryl)-5-oxo-1H-1,2,4-triazol-4(5H)-ylimino)-methyl)-phenyl)-4-oxobutanoates
(3)
using
biologically
important
1,2,4-triazole.
The
condensation
3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones
(1)
4-formyl-2-methoxyphenyl-4-(4-formyl-2-methoxyphenyl)-4-oxobutanoate
yielded
active
(3).
compounds
obtained
were
analyzed
via
FT-IR,1H-/13C-NMR
spectrometers,
elemental
analysis,
HRMS
spectroscopic
techniques.
Furthermore,
we
aimed
at
investigating
3a-g
against
FaDu
hypopharyngeal
cells.
We
demonstrated
that
3c,
3e,
3
g
had
lower
IC50
values
compared
remaining
tested
more
importantly
their
comparable
5-FU,
which
suggests
them
as
agent
candidates.
These
newly
synthesized
assessed
for
inhibitory
activities
toward
two
human
carbonic
anhydrase
isoforms
I
II
(hCA
II).
Then,
molecular
docking
calculations
made
compare
biological
studied
molecules
proteins.
Compound
3c
has
a
score
−7.15
squamous
cell
carcinoma
protein
ID:
2DO4
−5.49
ID:5PJZ.
ADME/T
analysis
performed
examine
drug
properties
molecules.
Synthesis,
Год журнала:
2024,
Номер
56(20), С. 3147 - 3159
Опубликована: Авг. 19, 2024
Abstract
A
diversity-oriented
total
synthesis
for
Amaryllidaceae
alkaloids
incorporating
the
frequently
found
C3a-arylated
hydroindole
moiety
was
developed.
Chiral-anion-induced
gold(I)
catalysis
employed
cyclization
of
1,4-diynes
to
pyrrolidine
and
installation
all-carbon
quaternary
stereocenter.
Both
enantiomeric
series
crinine-type
in
high
enantiopurity
were
accessible
by
this
methodology.
The
formal
a
wide
range
is
described,
such
as
(+)-vitattine,
(–)-epi-vitattine,
(–)-elwesein,
(–)-epi-elwesein,
(–)-crinine,
(–)-epi-crinine,
(–)-buphanisine,
(–)-flexinine,
(+)-gracilamine.
