Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Янв. 31, 2023
Bacille
Calmette-Guérin
(BCG)
is
the
only
approved
vaccine
for
tuberculosis
(TB)
prevention
worldwide.
BCG
has
an
excellent
protective
effect
on
miliary
and
tuberculous
meningitis
in
children
or
infants.
Interestingly,
a
growing
number
of
studies
have
shown
that
vaccination
can
induce
nonspecific
specific
immunity
to
fight
against
other
respiratory
disease
pathogens,
including
SARS-CoV-2.
The
continuous
emergence
variants
SARS-CoV-2
makes
efficiency
COVID-19-specific
vaccines
unprecedented
challenge.
Therefore,
it
been
hypothesized
BCG-induced
trained
might
protect
COVID-19
infection.
This
study
comprehensively
described
mechanism
immunity.
In
addition,
this
also
reviewed
research
revaccination
prevent
TB,
impact
non-tuberculous
diseases,
clinical
trials
These
data
will
provide
new
evidence
confirm
hypotheses
mentioned
above.
Biomolecules,
Год журнала:
2024,
Номер
14(10), С. 1320 - 1320
Опубликована: Окт. 17, 2024
The
Coronavirus
disease
2019
(COVID-19)
pandemic,
caused
by
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2),
has
prompted
a
massive
global
vaccination
campaign,
leading
to
the
rapid
development
and
deployment
of
several
vaccines.
Various
COVID-19
vaccines
are
under
different
phases
clinical
trials
include
whole
virus
or
its
parts
like
DNA,
mRNA,
protein
subunits
administered
directly
through
vectors.
Beginning
in
2020,
few
mRNA
(Pfizer-BioNTech
BNT162b2
Moderna
mRNA-1273)
adenovirus-based
(AstraZeneca
ChAdOx1-S
Janssen
Ad26.COV2.S)
were
recommended
WHO
for
emergency
use
before
completion
phase
3
4
trials.
These
mostly
two
three
doses
at
defined
frequency
between
doses.
While
these
vaccines,
mainly
based
on
viral
nucleic
acids
conferred
protection
against
progression
SARS-CoV-2
infection
into
COVID-19,
prevented
death
due
disease,
their
also
been
accompanied
plethora
side
effects.
Common
effects
localized
reactions
such
as
pain
injection
site,
well
systemic
fever,
fatigue,
headache.
symptoms
generally
mild
moderate
resolve
within
days.
However,
rare
but
more
serious
have
reported,
including
allergic
anaphylaxis
and,
some
cases,
myocarditis
pericarditis,
particularly
younger
males.
Ongoing
surveillance
research
efforts
continue
refine
understanding
adverse
effects,
providing
critical
insights
risk-benefit
profile
Nonetheless,
overall
safety
supports
continued
combating
with
regulatory
agencies
health
organizations
emphasizing
importance
preventing
COVID-19's
outcomes.
In
this
review,
we
describe
types
summarize
various
autoimmune
inflammatory
response(s)
manifesting
predominantly
cardiac,
hematological,
neurological,
psychological
dysfunctions.
incidence,
presentation,
risk
factors,
diagnosis,
management
possible
mechanisms
contributing
discussed.
review
highlights
potential
ambivalence
human
response
post-COVID-19
necessitates
need
mitigate
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(23), С. 14670 - 14670
Опубликована: Ноя. 24, 2022
Findings
collected
over
two
and
a
half
years
of
the
COVID-19
pandemic
demonstrated
that
level
immunity
resulting
from
vaccination
infection
is
insufficient
to
stop
circulation
new
genetic
variants.
The
short-term
decline
in
morbidity
was
followed
by
steady
increase.
early
identification
lineages
will
require
vaccine
adaptation
future
an
important
research
target.
In
this
study,
we
summarised
data
on
variability
line
composition
throughout
Moscow,
Russia,
evaluated
virological
epidemiological
features
dominant
variants
context
selected
prophylaxes.
prevalence
Omicron
variant
highlighted
low
effectiveness
existing
immune
layer
preventing
infection,
which
points
necessity
optimising
antigens
used
vaccines
Moscow.
Logistic
growth
curves
showing
rate
at
displaces
previously
may
serve
as
indicators
for
selecting
candidates
updated
vaccines,
along
with
estimates
efficacy,
reduced
viral
neutralising
activity
against
strains,
load
vaccinated
patients.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Янв. 31, 2023
Bacille
Calmette-Guérin
(BCG)
is
the
only
approved
vaccine
for
tuberculosis
(TB)
prevention
worldwide.
BCG
has
an
excellent
protective
effect
on
miliary
and
tuberculous
meningitis
in
children
or
infants.
Interestingly,
a
growing
number
of
studies
have
shown
that
vaccination
can
induce
nonspecific
specific
immunity
to
fight
against
other
respiratory
disease
pathogens,
including
SARS-CoV-2.
The
continuous
emergence
variants
SARS-CoV-2
makes
efficiency
COVID-19-specific
vaccines
unprecedented
challenge.
Therefore,
it
been
hypothesized
BCG-induced
trained
might
protect
COVID-19
infection.
This
study
comprehensively
described
mechanism
immunity.
In
addition,
this
also
reviewed
research
revaccination
prevent
TB,
impact
non-tuberculous
diseases,
clinical
trials
These
data
will
provide
new
evidence
confirm
hypotheses
mentioned
above.
