Role of Non-coding RNAs in Rheumatoid Arthritis and Supervision Mechanism of Chinese Medicine
Chinese Journal of Integrative Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 8, 2025
Язык: Английский
Dysregulated circular RNAs in rheumatoid arthritis: Cellular roles and clinical prospects
Autoimmunity Reviews,
Год журнала:
2025,
Номер
unknown, С. 103774 - 103774
Опубликована: Фев. 1, 2025
Язык: Английский
Elucidating the immunomodulatory roles and mechanisms of CUL4B in the immune system: a comprehensive review
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 31, 2025
Cullin
4B
(CUL4B),
a
pivotal
member
of
the
Cullins
protein
family,
plays
crucial
role
in
immune
regulation
and
has
garnered
significant
research
attention.
CUL4B,
through
4B-RING
E3
ubiquitin
ligase
(CRL4B)
complex,
regulates
CD4+
T
cell
differentiation,
fostering
balance
between
TH1
TH2
subsets,
expedites
DNA
damage
repair
to
bolster
persistence.
In
B
cells,
CUL4B
upregulation
stimulates
responses
but
is
linked
an
unfavorable
prognosis
lymphoma.
innate
immunity,
modulates
Toll-like
receptor
(TLR)-mediated
anti-inflammatory
responses,
enhancing
macrophage
migration
adhesion.
also
potentiating
anti-tumor
immunity
by
restricting
activity
myeloid-derived
suppressor
cells
(MDSCs).
disease
pathogenesis,
limits
MDSCs
enhance
effects,
its
inhibition
experimental
autoimmune
encephalomyelitis
(EAE)
models
have
demonstrated
beneficial
underscoring
potential
therapeutic
significance
diseases.
Furthermore,
involved
various
immune-related
cancers
inflammation,
including
pleural
mesothelioma,
human
osteosarcoma,
colitis-associated
cancer.
metabolic
diseases,
adipose
tissue
insulin
sensitivity,
with
depletion
improving
phenotypes.
This
review
highlights
maintaining
homeostasis
provides
novel
perspectives
insights
into
understanding
development
treatments
for
disorders.
Язык: Английский
The role of non‐coding RNAs in fibroblast‐like synoviocytes in rheumatoid arthritis
International Journal of Rheumatic Diseases,
Год журнала:
2024,
Номер
27(10)
Опубликована: Окт. 1, 2024
Abstract
Rheumatoid
arthritis
(RA)
is
an
inflammatory
autoimmune
disease
characterized
by
synovial
hyperplasia,
and
fibroblast‐like
synoviocytes
(FLSs)
constitute
the
majority
of
cells
in
tissue,
playing
a
crucial
role
onset
RA.
Dysregulation
FLSs
function
critical
strategy
treating
joint
damage
associated
with
Non‐coding
RNAs,
class
RNA
molecules
that
do
not
encode
proteins,
participate
development
various
diseases.
This
article
aims
to
review
progress
study
long
non‐coding
microRNAs,
circular
RNAs
FLSs.
are
involved
pathogenesis
RA,
directly
or
indirectly
regulating
FLSs'
proliferation,
migration,
invasion,
apoptosis,
responses.
Furthermore,
also
influence
DNA
methylation
osteogenic
differentiation
Therefore,
hold
promise
as
biomarkers
for
diagnosing
Targeting
locally
represents
potential
future
therapies
Язык: Английский