The role of non‐coding RNAs in fibroblast‐like synoviocytes in rheumatoid arthritis DOI
Yuexiang Zheng, Xiaoyu Cai,

Fujia Ren

et al.

International Journal of Rheumatic Diseases, Journal Year: 2024, Volume and Issue: 27(10)

Published: Oct. 1, 2024

Abstract Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by synovial hyperplasia, and fibroblast‐like synoviocytes (FLSs) constitute the majority of cells in tissue, playing a crucial role onset RA. Dysregulation FLSs function critical strategy treating joint damage associated with Non‐coding RNAs, class RNA molecules that do not encode proteins, participate development various diseases. This article aims to review progress study long non‐coding microRNAs, circular RNAs FLSs. are involved pathogenesis RA, directly or indirectly regulating FLSs' proliferation, migration, invasion, apoptosis, responses. Furthermore, also influence DNA methylation osteogenic differentiation Therefore, hold promise as biomarkers for diagnosing Targeting locally represents potential future therapies

Language: Английский

Role of Non-coding RNAs in Rheumatoid Arthritis and Supervision Mechanism of Chinese Medicine DOI
Shu Li, Hong Fang,

Lei Wan

et al.

Chinese Journal of Integrative Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

Citations

0
Dysregulated circular RNAs in rheumatoid arthritis: Cellular roles and clinical prospects DOI
Mengshi Tang, Hongxing Li,

Siyuan Chang

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103774 - 103774

Published: Feb. 1, 2025

Language: Английский

Citations

0
Elucidating the immunomodulatory roles and mechanisms of CUL4B in the immune system: a comprehensive review DOI Creative Commons

Siyu He,

Ziyue Wang,

Yinan Zhu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 31, 2025

Cullin 4B (CUL4B), a pivotal member of the Cullins protein family, plays crucial role in immune regulation and has garnered significant research attention. CUL4B, through 4B-RING E3 ubiquitin ligase (CRL4B) complex, regulates CD4+ T cell differentiation, fostering balance between TH1 TH2 subsets, expedites DNA damage repair to bolster persistence. In B cells, CUL4B upregulation stimulates responses but is linked an unfavorable prognosis lymphoma. innate immunity, modulates Toll-like receptor (TLR)-mediated anti-inflammatory responses, enhancing macrophage migration adhesion. also potentiating anti-tumor immunity by restricting activity myeloid-derived suppressor cells (MDSCs). disease pathogenesis, limits MDSCs enhance effects, its inhibition experimental autoimmune encephalomyelitis (EAE) models have demonstrated beneficial underscoring potential therapeutic significance diseases. Furthermore, involved various immune-related cancers inflammation, including pleural mesothelioma, human osteosarcoma, colitis-associated cancer. metabolic diseases, adipose tissue insulin sensitivity, with depletion improving phenotypes. This review highlights maintaining homeostasis provides novel perspectives insights into understanding development treatments for disorders.

Language: Английский

Citations

0
The role of non‐coding RNAs in fibroblast‐like synoviocytes in rheumatoid arthritis DOI
Yuexiang Zheng, Xiaoyu Cai,

Fujia Ren

et al.

International Journal of Rheumatic Diseases, Journal Year: 2024, Volume and Issue: 27(10)

Published: Oct. 1, 2024

Abstract Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by synovial hyperplasia, and fibroblast‐like synoviocytes (FLSs) constitute the majority of cells in tissue, playing a crucial role onset RA. Dysregulation FLSs function critical strategy treating joint damage associated with Non‐coding RNAs, class RNA molecules that do not encode proteins, participate development various diseases. This article aims to review progress study long non‐coding microRNAs, circular RNAs FLSs. are involved pathogenesis RA, directly or indirectly regulating FLSs' proliferation, migration, invasion, apoptosis, responses. Furthermore, also influence DNA methylation osteogenic differentiation Therefore, hold promise as biomarkers for diagnosing Targeting locally represents potential future therapies

Language: Английский

Citations

2