Hydrogels: Classifications, fundamental properties, applications, and scopes in recent advances in tissue engineering and regenerative medicine – A comprehensive review
Arabian Journal of Chemistry,
Год журнала:
2024,
Номер
17(10), С. 105968 - 105968
Опубликована: Авг. 17, 2024
Hydrogels
are
three-dimensional
structures
that
serve
as
substitutes
for
the
extracellular
matrix
(ECM)
and
possess
outstanding
physicochemical
biochemical
characteristics.
They
gaining
importance
in
regenerative
medicine
because
of
their
similarity
to
natural
terms
moisture
content
wound
tissue
healing
permeability.
Tissue
engineering
advancements
have
resulted
development
flexible
hydrogels
mimic
dynamic
characteristics
ECM.
Several
approaches
been
applied
produce
from
biopolymers
with
enhanced
functional
structural
different
applications
(TERM).
This
review
provides
a
comprehensive
overview
hydrogel
healing,
engineering,
drug
delivery
systems.
We
outline
types
based
on
physical
chemical
crosslinking,
fundamental
properties,
TERM.
article
provided
recent
literature
within
five
years.
Recent
developments
biopolymer-based
state-of-the-art
discussed,
emphasizing
significant
challenges
future
perspectives.
Язык: Английский
Biofunctionalized agarose-based biopolymer composites for advanced biomedical applications: a review
Sutharsan Karunanithi,
Kalaivizhi Rajappan
Polymer Bulletin,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Язык: Английский
Antibacterial collagen-guar gum hydrogels with zeolitic imidazolate framework-67 (ZIF-67): an innovative platform for advanced wound healing
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2025,
Номер
unknown, С. 1 - 26
Опубликована: Апрель 1, 2025
The
current
challenge
in
developing
wound
healing
dressings
lies
achieving
antibacterial
effects
while
avoiding
cytotoxicity
to
cells
that
are
crucial
for
the
process.
Addressing
this
challenge,
Zeolitic
Imidazolate
Framework-67
(ZIF-67),
a
cobalt-containing
metal-organic
framework
(MOF),
has
emerged
as
promising
additive
due
cobalt's
broad-spectrum
antimicrobial
effects.
This
study
developed
semi-interpenetrating
polymer
network
(semi-IPN)
hydrogels
by
incorporating
1-3
wt.%
ZIF-67
into
collagen-guar
gum
matrices,
resulting
biocomposites
with
tunable
structural
and
functional
properties.
These
exhibit
fibrillar-granular
morphology,
uniform
cobalt
ion
distribution
on
semi-crystalline
surface,
strong
activity
against
Escherichia
coli
(E.
coli).
At
3
wt.%,
accelerates
gelation,
strengthens
crosslinking
interactions,
enhances
storage
modulus,
thermal
stability,
hydrolytic
resistance
of
hydrogels.
Furthermore,
1
also
function
in-situ
curcumin
delivery
systems,
offering
controlled
release
under
physiological
conditions
significant
biodegradation
presence
collagenase.
In
vitro
tests
demonstrate
chemical
composition
these
hydrogels,
regardless
content,
effectively
supports
monocyte
fibroblast
metabolic
activity,
promotes
cell
proliferation,
increases
interleukin-10
(IL-10)
secretion
human
monocytes.
Additionally,
absence
hemolytic
blood
further
underscores
safety
suitability
hydrogel
advanced
treatment
applications.
Язык: Английский
Fabrication of composite hydrogels from Carrageenan-cl-carboxymethyl chitosan-PVA incorporated ZiF-8 for wound healing applications
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
Abstract
The
skin
is
the
largest
organ
of
human
body,
protecting
it
from
external
environment
and
pathogens
minimizing
risk
injury.
Hydrogels
have
attracted
a
lot
interest
lately
because
their
biomimetic
structure
inherent
extracellular
matrix
characteristics.
hold
great
promise
for
application
in
wound
healing,
mainly
they
can
very
conveniently
provide
bioactive
ingredients.
In
this
work,
composite
hydrogels
were
developed
healing
carrageenan,
polyvinyl
alcohol,
carboxymethyl
chitosan
by
blending
method.
These
characterized
advanced
techniques
such
as
FTIR,
XRD,
DSC,
SEM-EDX,
which
used
to
study
structural,
thermal,
surface
morphology,
elemental
behavior.
Their
physiochemical
analyses
performed
using
swelling
degradation,
water
contact
angle,
gel
fraction.
increasing
ZiF-8
causes
more
roughness,
with
decreased
different
media
(Aqueous>PBS>NaCl).
amount
less
hydrophilic
behavior
biodegradation
cytocompatibility
ZiF-8-based
potential
antibacterial
activities
against
Gram-positive
Gram-negative,
enhanced
ZiF-8.
caused
cell
viability
proliferation
proper
morphology
vivo
healing.
Hence,
results
show
that
synthesized
may
be
candidate
numerous
repair
applications.
Язык: Английский
Recent advances of bone tissue engineering: carbohydrate and ceramic materials, fundamental properties and advanced biofabrication strategies ‒ a comprehensive review
Biomedical Materials,
Год журнала:
2024,
Номер
19(5), С. 052005 - 052005
Опубликована: Авг. 6, 2024
Abstract
Bone
is
a
dynamic
tissue
that
can
always
regenerate
itself
through
remodeling
to
maintain
biofunctionality.
This
performs
several
vital
physiological
functions.
However,
bone
scaffolds
are
required
for
critical-size
damages
and
fractures,
these
be
addressed
by
engineering.
engineering
(BTE)
has
the
potential
develop
repairing
damaged
bone.
BTE
multidisciplinary
engineered
scaffold
with
desired
properties
tissue.
Herein,
we
have
provided
an
overview
of
common
carbohydrate
polymers,
fundamental
structural,
physicochemical,
biological
properties,
fabrication
techniques
We
also
discussed
advanced
biofabrication
strategies
limitations
prospects
highlighting
significant
issues
in
There
review
articles
available
on
state-of-the-art
article
recent
progress
trends
within
last
3–5
years
emphasizing
challenges
future
perspectives.
Язык: Английский
Innovative Nanocomposite Scaffolds Containing ZIF-8 Nanoparticles for Improving Wound Healing: A Review
Journal of Polymers and the Environment,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 17, 2024
Язык: Английский
Advanced Wound Healing: The Synergy of Nature and Nanotechnology
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
unknown, С. 106579 - 106579
Опубликована: Дек. 1, 2024
Язык: Английский
Natural Fiber-Based Polymer Composites for Biomedical Applications
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2024,
Номер
unknown, С. 1 - 58
Опубликована: Дек. 9, 2024
Natural
fibers
such
as
kenaf,
sisal,
ramie,
jute,
hemp,
flax,
coir,
banana
and
bamboo
have
been
employed
in
the
production
of
biocomposites.
A
great
strength-to-weight
ratio,
renewability
sustainability
are
some
important
properties
natural
fibers.
Biocomposites
produced
from
biomedical
fields
delivery
drug,
orthopaedic
applications,
tissue
engineering
wound
dressing
owing
to
their
acceptability
by
human
body,
moderate
mechanical
performance
environmental
benefits.
This
study
presents
recent
advances
field
polymers
fiber-based
polymer
composites
for
potential
applications.
For
this
purpose,
given
detailed
examples
literature
works
used
applications
discussed.
Язык: Английский