Targeting Cytokine Dysregulation in Psoriasis: The Role of Dietary Interventions in Modulating the Immune Response

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2895 - 2895

Опубликована: Март 22, 2025

Psoriasis is a chronic immune-mediated skin disease characterized by cytokine dysregulation. Pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-17, and IL-23, play pivotal roles in the pathogenesis of psoriasis. Emerging evidence suggests that dietary interventions can modulate activity, providing complementary approach to standard therapies. This narrative review examines impact various strategies, Mediterranean diet, ketogenic gluten-free fasting-mimicking on profiles clinical outcomes Research insights reveal components such as omega-3 fatty acids, polyphenols, short-chain acids influence immune signaling pathways. These pathways include nuclear factor-kappa B (NF-κB) Signal Transducer Activator Transcription 3 (STAT3). Additionally, these promote anti-inflammatory effects mediated gut microbiota. Clinical studies demonstrate significant reductions psoriasis severity, improved quality life, modulation key cytokines associated with activity. Despite advancements, challenges persist effectively integrating findings into practice. variability patient responses, adherence issues, need for robust biomarkers monitor efficacy. Future directions emphasize potential personalized nutrition precision medicine approaches optimize tailored individual genetic predispositions. Integrating strategies care could transform treatment paradigms simultaneously addressing both systemic inflammation comorbid conditions.

Язык: Английский

Obesity and nutritional strategies: advancing prevention and management through evidence-based approaches

Food and Agricultural Immunology, Год журнала: 2025, Номер 36(1)

Опубликована: Апрель 20, 2025

Язык: Английский