Targeting Cytokine Dysregulation in Psoriasis: The Role of Dietary Interventions in Modulating the Immune Response

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2895 - 2895

Published: March 22, 2025

Psoriasis is a chronic immune-mediated skin disease characterized by cytokine dysregulation. Pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-17, and IL-23, play pivotal roles in the pathogenesis of psoriasis. Emerging evidence suggests that dietary interventions can modulate activity, providing complementary approach to standard therapies. This narrative review examines impact various strategies, Mediterranean diet, ketogenic gluten-free fasting-mimicking on profiles clinical outcomes Research insights reveal components such as omega-3 fatty acids, polyphenols, short-chain acids influence immune signaling pathways. These pathways include nuclear factor-kappa B (NF-κB) Signal Transducer Activator Transcription 3 (STAT3). Additionally, these promote anti-inflammatory effects mediated gut microbiota. Clinical studies demonstrate significant reductions psoriasis severity, improved quality life, modulation key cytokines associated with activity. Despite advancements, challenges persist effectively integrating findings into practice. variability patient responses, adherence issues, need for robust biomarkers monitor efficacy. Future directions emphasize potential personalized nutrition precision medicine approaches optimize tailored individual genetic predispositions. Integrating strategies care could transform treatment paradigms simultaneously addressing both systemic inflammation comorbid conditions.

Language: Английский

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Obesity and nutritional strategies: advancing prevention and management through evidence-based approaches

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: April 20, 2025

Language: Английский

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Effectiveness and Safety of Preoperative Nutritional Interventions on Surgical Outcomes in Patients Undergoing Metabolic and Bariatric Surgery: A Systematic Review and Meta-Analysis

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1533 - 1533

Published: April 30, 2025

Background: Preoperative nutritional interventions, including low-calorie diets (LCDs) and very (VLCDs), are commonly implemented in metabolic bariatric surgery. This systematic review meta-analysis aimed to evaluate the efficacy safety of preoperative dietary interventions patients undergoing surgery, with primary outcomes perioperative complications, operative time, length hospital stay. Methods: A were conducted, studies that compared LCD VLCD regular adults The assessed Random- fixed effects models used for quantitative synthesis. Risk bias was evaluated using Cochrane Bias tool ROBINS-I, while certainty evidence GRADE approach. Results: Eight trials comprising 1197 included meta-analysis. VLCDs associated a significant reduction complications (OR 0.59; 95% CI: 0.37-0.94; p = 0.03), whereas LCDs showed no effect on 1.64; 0.71-3.78; 0.25). No time observed (MD -2.64 min; -6.01 0.73; 0.12). Hospital stay slightly reduced -0.17 days; 0.0001), though clinical significance remains uncertain. low, primarily due risk small sample sizes. Conclusions: may lower do not appear provide this benefit. However, is limited by methodological heterogeneity low certainty. Further high-quality needed establish optimal protocols.

Language: Английский

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Harnessing nutrition to combat MASLD: a comprehensive guide to food-based therapeutic strategies

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: May 6, 2025

Language: Английский

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Oesophageal adenocarcinoma, obesity, and cancer: the role of nutrition in prevention and management

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: May 29, 2025

Language: Английский

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Obesity and endometrial cancer: biological mechanisms, nutritional strategies, and clinical perspectives

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: June 4, 2025

Language: Английский

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"Weighty Matters: Unraveling the Impact of Obesity on Colorectal Cancer and Nutritional Interventions"

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: June 1, 2025

Language: Английский

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