Reproduction and Fertility, Год журнала: 2024, Номер 5(4)
Опубликована: Окт. 1, 2024
Abstract Maternal gut microbiome impairment has garnered attention for its potential role in influencing neurodevelopmental outcomes offspring, especially situations that increase brain vulnerability such as perinatal asphyxia (PA). and fetal interplay emerge a critical link between maternal health offspring neurodevelopment. This study aims to generate model assess the impact of dysbiosis triggered by gestational antibiotic administration PA on Wistar rats were subjected antibiotics drinking water from 11th day until birth. On 6th postnatal day, pups PA/normoxia, resulting four experimental groups: control-normoxia, antibiotics-normoxia, control-asphyxia, antibiotics-asphyxia. Early-life behavioral tests conducted days 7 9. The initial antimicrobial cocktail (ampicillin, vancomycin, neomycin, clindamycin, amphotericin-B) led an increased number miscarriages, poor weight gain during pregnancy, reduced weight, changes compared control. Offspring presented impaired reflexes both groups hippocampal neuroinflammation. Due these detrimental effects, more pregnancy-safe was used second experiment meropenem). resulted no miscarriages or pregnancy-weight loss but still linked disruption. neuroinflammation, effects amplified administration. These preliminary findings reveal cumulative neurodevelopment impairment, emphasizing caution use. Further investigations should include long-term follow-up behavior integrate probiotics counteract effects. Graphical abstract Lay summary investigates disruptions caused treatment low oxygen exposure shortly after birth development rats’ babies. We found levels early inflammation nervous tissue baby rats. Although using different, potentially safer combination pregnancy complications, it changed bacteria mother’s worsened behavior. show can affect developing careful consideration be before prescribing them. Future research will explore longer-term medicines.
Язык: Английский