The Promise of Neurolaw in Global Justice: An Interview with Dr. Pragya Mishra

Challenges, Journal Year: 2025, Volume and Issue: 16(1), P. 15 - 15

Published: March 6, 2025

In an ongoing series of interviews, Challenges Advisory Board member and Nova Institute for Health Fellow Alan C. Logan meets with thought leaders, scientists, scholars, healthcare professionals, artisans, visionaries concerned about health at the scale individuals, communities, planet. Here, Dr. Pragya Mishra responds to a set questions posed by Challenges. Mishra, legal academician one few global scholars PhD specifically in neurolaw, is forefront research examining intersection law brain sciences. As concept developing field, promise neurolaw that it will lead more equitable less punitive justice system, based on objective science rather than prescientific assumptions blameworthiness willpower. reflects promises pitfalls growing challenges free held courts, her work field epitomizes transdisciplinary effort. She discusses place contemplative practices within special emphasis hope rehabilitation. describes through holistic lens, embraces future possibilities shaping evidence-based policy changes. While planetary as broad term, has paid little attention criminal system. Discussions are important ethical frameworks health. Neurolaw, explains, heart many interconnected our time.

Language: Английский

Abnormal microbiota due to prenatal antibiotic as a possible risk factor for Attention-Deficit / Hyperactivity Disorder (ADHD)

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown, P. 299 - 328

Published: Jan. 1, 2025

Language: Английский

The Trials and Errors of Developing an Experimental Model to Study the Impact of Maternal Gut Microbiome Disruption on Perinatal Asphyxia

Reproduction and Fertility, Journal Year: 2024, Volume and Issue: 5(4)

Published: Oct. 1, 2024

Abstract Maternal gut microbiome impairment has garnered attention for its potential role in influencing neurodevelopmental outcomes offspring, especially situations that increase brain vulnerability such as perinatal asphyxia (PA). and fetal interplay emerge a critical link between maternal health offspring neurodevelopment. This study aims to generate model assess the impact of dysbiosis triggered by gestational antibiotic administration PA on Wistar rats were subjected antibiotics drinking water from 11th day until birth. On 6th postnatal day, pups PA/normoxia, resulting four experimental groups: control-normoxia, antibiotics-normoxia, control-asphyxia, antibiotics-asphyxia. Early-life behavioral tests conducted days 7 9. The initial antimicrobial cocktail (ampicillin, vancomycin, neomycin, clindamycin, amphotericin-B) led an increased number miscarriages, poor weight gain during pregnancy, reduced weight, changes compared control. Offspring presented impaired reflexes both groups hippocampal neuroinflammation. Due these detrimental effects, more pregnancy-safe was used second experiment meropenem). resulted no miscarriages or pregnancy-weight loss but still linked disruption. neuroinflammation, effects amplified administration. These preliminary findings reveal cumulative neurodevelopment impairment, emphasizing caution use. Further investigations should include long-term follow-up behavior integrate probiotics counteract effects. Graphical abstract Lay summary investigates disruptions caused treatment low oxygen exposure shortly after birth development rats’ babies. We found levels early inflammation nervous tissue baby rats. Although using different, potentially safer combination pregnancy complications, it changed bacteria mother’s worsened behavior. show can affect developing careful consideration be before prescribing them. Future research will explore longer-term medicines.

Language: Английский