International Journal of Biological Macromolecules, Год журнала: 2022, Номер 217, С. 111 - 119
Опубликована: Июнь 25, 2022
Язык: Английский
Foods, Год журнала: 2022, Номер 11(15), С. 2189 - 2189
Опубликована: Июль 23, 2022
Plant polyphenols have attracted considerable attention because of their key roles in preventing many diseases, including high blood sugar, cholesterol, and cancer. A variety functional foods been designed developed with plant as the main active ingredients. Polyphenols mainly come from vegetables fruits can generally be divided according to structure into flavonoids, astragalus, phenolic acids, lignans. are a group plant-derived food ingredients different molecular structures various biological activities antioxidant, anti-inflammatory, anticancer properties. However, polyphenolic compounds low oral bioavailability, which limits application nutraceuticals. Fortunately, green bio-based nanocarriers well suited for encapsulating, protecting, delivering polyphenols, thereby improving bioavailability. In this paper, health benefits prevention diseases summarized, review research progress improvement bioavailability polyphenols. great potential formulations nutrition products. future, development food-grade delivery carriers encapsulation could solve limitations poor water solubility practical applications.
Язык: Английский
Процитировано
152
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(1), С. 585 - 611
Опубликована: Янв. 5, 2024
Numerous surgeries are carried out to replace tissues that have been harmed by an illness or accident. Due various surgical interventions and the requirement of bone substitutes, emerging field tissue engineering attempts repair damaged with help scaffolds. These scaffolds act as template for regeneration controlling development new cells. For creation functional organs, there three elements play very crucial role: cells, signals achievement these aims, types natural polymers, like chitosan, chitin, cellulose, albumin silk fibroin, used preparation Scaffolds produced from polymers many advantages: they less immunogenic well being biodegradable, biocompatible, non-toxic cost effective. The hierarchal structure bone, microscale nanoscale, is mostly made up organic inorganic components nanohydroxyapatite collagen components. This review paper summarizes knowledge updates information about use scaffolds, their application in recent research trends area (BTE). article extensively explores related analyze advancement nanotechnology treatment bone-related diseases repair.
Язык: Английский
Процитировано
27
Food Chemistry X, Год журнала: 2024, Номер 24, С. 101953 - 101953
Опубликована: Ноя. 2, 2024
Nanotechnology plays a pivotal role in food science, particularly the nanoencapsulation of bioactive compounds, to enhance their stability, bioavailability, and therapeutic potential. This review aims provide comprehensive analysis encapsulation emphasizing characteristics, applications, implications for human health. work offers detailed comparison polymers such as sodium alginate, gum Arabic, chitosan, cellulose, pectin, shellac, xanthan gum, while also examining both conventional emerging techniques, including freeze-drying, spray-drying, extrusion, coacervation, supercritical anti-solvent drying. The contribution this lies highlighting improving system controlling release rates, maintaining bioactivity under extreme conditions, reducing lipid oxidation. Furthermore, it explores recent technological advances aimed at optimizing processes targeted therapies functional foods. findings underline significant potential not only supplements foods but supportive medical treatments, showcasing its relevance health various contexts.
Язык: Английский
Процитировано
17
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Янв. 31, 2024
In the cutting-edge era of developing precision therapeutics, nanoparticles have emerged as a potent drug delivery system. Altering size poorly water-soluble drugs to nanoscale could confer change in their physical properties, including enhanced water solubility and bioavailability. Evodiamine (EVO), natural indolequinone alkaloid extract from Evodia rutaecarpa, has shown several important pharmacological applications, anti-cancer being one them. Protein-based nano-drug systems gained interest researchers due better biocompatibility, biodegradability, non-immunogenicity non-toxicity. present study, EVO encapsulated BSA (ENPs) were synthesized characterized, which nanoscale-sized (~ 150 nm), monodispersed, spherical shaped, showed high entrapment efficiency 86%) controlled release. The in-vitro activity ENPs on human breast cancer cells was dose- time-dependent. apoptotic molecular mechanism investigated using FACS, qRT-PCR, western blotting analysis, revealed increased expression p53 Bax decreased Bcl-2. Biological studies demonstrated comparatively more efficient targeted than pure EVO. comprehensive physiochemical characterization validation collectively pinpoint promising avenue for harnessing therapeutic potential compound findings indicate improved cytotoxicity, positioning propitious strategy advancing treatment.
Язык: Английский
Процитировано
15
Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2024, Номер 23(3)
Опубликована: Апрель 5, 2024
Abstract The importance of food quality and safety lies in ensuring the best product to meet consumer demands public health. Advanced technologies play a crucial role minimizing risk foodborne illnesses, contamination, drug residue, other potential hazards food. Significant materials technological advancements have been made throughout supply chain. Among them, quantum dots (QDs), as class advanced nanomaterials with unique physicochemical properties, are progressively demonstrating their value field safety. This review aims explore cutting‐edge research on different applications QDs safety, including encapsulation bioactive compounds, detection analytes, preservation packaging, intelligent freshness indicators. Moreover, modification strategies toxicities diverse outlined, which can affect performance hinder industry. findings suggested that mainly used analyte active/intelligent packaging. Various analytes be detected using QD‐based sensors, heavy metal ions, pesticides, antibiotics, microorganisms, additives, functional components. QD incorporation aided improving antibacterial antioxidant activities film/coatings, resulting extended shelf life for packaged Finally, perspectives critical challenges productivity, toxicity, practical application also summarized. By consolidating these essential aspects into this review, way developing high‐performance is presented researchers technologists better capitalize upon technology applications.
Язык: Английский
Процитировано
11
Food Hydrocolloids, Год журнала: 2025, Номер unknown, С. 111092 - 111092
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 303, С. 140627 - 140627
Опубликована: Фев. 2, 2025
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2025, Номер 17(5), С. 750 - 750
Опубликована: Фев. 20, 2025
Background: Skeletal muscle, as the largest organ in body and main protein pool, is crucial for various physiological processes, but atrophy of skeletal muscle can result from glucocorticoids, including dexamethasone, or aging. Astaxanthin (AST) a ketocarotenoid with variety activities. However, clinical application AST hampered by its strong hydrophobicity, intense off-flavors, susceptibility to oxidation. Methods: In this study, we prepared whey isolate (WPI)-encapsulated nanoemulsion (WPI-AST, W-A) investigated alleviating effects on dexamethasone-induced atrophy. Results: The optimal concentration astaxanthin was determined be 30 mg/mL an oil/water ratio 1:5. W-A typical oil-in-water (O/W) emulsion particle size about 110 nm. bioaccessibility significantly improved, off-flavors effectively masked. After oral administration, further ameliorated inhibiting catabolism, promoting production, mitochondrial autophagy compared same dose WPI AST. addition this, improved glycometabolism reducing expression Foxo3 increasing PGC-1α. Conclusions: conclusion, demonstrated good therapeutic value
Язык: Английский
Процитировано
0
ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
Liver disorders like hepatitis, cirrhosis, and hepatocellular carcinoma present a significant global health challenge, with high morbidity mortality rates. Key factors contributing to liver include inflammation, oxidative stress, apoptosis. Due their multifaceted action, natural compounds are promising candidates for mitigating liver-related disorders. Research studies revealed the antioxidant, anti-inflammatory, detoxifying properties of curcumin, glycyrrhizin, silymarin potential detoxification protection. With advancements in nanotechnology drug delivery, have improved stability targetability, thereby enhancing bioavailability therapeutic efficiency. Further, recent genomics an increased understanding genetic influencing hepatoprotective effects agents made way personalized medicine. Moreover, combinatorial therapy products, synthetic drugs, or other has outcomes. Even though clinical trials confirmed efficiency as agents, several challenges remain unanswered translation practice. Therefore, it is logical integrate further advance hepatoprotection. This review gives overview substantial progress field hepatoprotection, specific emphasis on integration genomics. provides valuable insights future research innovations developing strategies
Язык: Английский
Процитировано
0
Materials, Год журнала: 2023, Номер 16(24), С. 7550 - 7550
Опубликована: Дек. 7, 2023
"Green" strategies to build up novel organic nanocarriers with bioperformance are modern trends in nanotechnology. In this way, the valorization of bio-wastes and use living systems develop multifunctional biogenic (OBNs) have revolutionized nanotechnological biomedical fields. This paper is a comprehensive review related OBNs for bioactives' delivery, providing an overview reports on past two decades. first part, several classes bioactive compounds their therapeutic role briefly presented. A broad section dedicated main categories nanocarriers. The major challenges regarding eco-design fate suggested overcome some toxicity-related drawbacks. Future directions opportunities, finding "green" solutions solving problems nanocarriers, outlined final paper. We believe that through review, we will capture attention readers open new perspectives solutions/ideas discovery more efficient ways developing bioperformant transporting agents.
Язык: Английский
Процитировано
12