Poultry Science, Год журнала: 2025, Номер unknown, С. 105178 - 105178
Опубликована: Апрель 1, 2025
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(18), С. 10713 - 10713
Опубликована: Сен. 14, 2022
Green tea's (Camellia sinensis) anticancer and anti-inflammatory effects are well-known. Catechins the most effective antioxidants among physiologically active compounds found in Camellia sinesis. Recent research demonstrates that number of hydroxyl groups presence specific structural have a substantial impact on antioxidant activity catechins. Unfermented green tea is finest source these chemicals. ability to effectively neutralize reactive oxygen species. The catechin derivatives include epicatechin (EC), epigallocatechin (EGC), gallate (ECG) (EGCG). EGCG has greatest potential. Notably, catechins been explored for their prevent variety cancers. Literature evidence, based epidemiological laboratory studies, indicates certain properties can serve as basis consideration lead molecules synthesis novel drugs further exploration role pharmacologically natural adjuvants standard chemotherapeutics. various sections article will focus how affect survival, proliferation, invasion, angiogenesis, metastasis tumors by modulating cellular pathways.
Язык: Английский
Процитировано
108
Frontiers in Nutrition, Год журнала: 2023, Номер 10
Опубликована: Июнь 21, 2023
Dietary medicinal plants are among the most sought-after topics in alternative medicine today due to their preventive and healing properties against many diseases.This study aimed extract determine polyphenols from indigenous extracts, i.e., Mentha longifolia, M. arvensis, Tinospora cordifolia, Cymbopogon citratus, Foeniculum vulgare, Cassia absus, Camellia sinensis, Trachyspermum ammi, C. sinensis then evaluate antioxidant, cytotoxicity, antimicrobial properties, besides enzyme inhibition of isolated polyphenols.The antioxidant activity was evaluated by DPPH, Superoxide radical, Hydroxyl radical (OH.), Nitric oxide (NO.) scavenging activity; antidiabetic enzymatic methods, anticancer using MTT assay, while antibacterial activity.The results showed that tested plants' polyphenolic extracts (MPPE) exhibited significant hydroxyl, nitric oxide, superoxide methods because considerable amounts total polyphenol flavonoid contents. UHPLC profile twenty-five complexes eight plant categorized into phenolic acids, flavonoids, alkaloids. The main 3-Feroylquinic acid (1,302 mg/L), also found has a higher content, rosmarinic acid, vanillic chlorogenic p-coumaric ferulic gallic catechin, luteolin, 7-O-neohesperideside, quercetin 3,7-O-glucoside, hesperidin, rutin, quercetin, caffeine range (560-780 mg/L). At same time, other compounds medium content (99-312 phenolics were 20-116% more abundant than those plants. While T. cordifolia is rich alkaloids, ammi lower content. assay Caco-2 cells citratus had maximum cytotoxicity. F. vulgare activity, minor α-amylase. Furthermore, S. aureus, B. cereus, E. coli, enterica.The principal component analysis demonstrated clear separation based on functional properties. These findings prove therapeutic effectiveness highlight importance as natural reserves phytogenic with untapped potential needs be discovered through advanced analytical methods.
Язык: Английский
Процитировано
45
Molecules, Год журнала: 2023, Номер 28(13), С. 5246 - 5246
Опубликована: Июль 6, 2023
Cellular signaling pathways involved in the maintenance of equilibrium between cell proliferation and apoptosis have emerged as rational targets that can be exploited prevention treatment cancer. Epigallocatechin-3-gallate (EGCG) is most abundant phenolic compound found green tea. It has been shown to regulate multiple crucial cellular pathways, including those mediated by EGFR, JAK-STAT, MAPKs, NF-κB, PI3K-AKT-mTOR, others. Deregulation abovementioned pathophysiology demonstrated EGCG may exert anti-proliferative, anti-inflammatory, apoptosis-inducing effects or induce epigenetic changes. Furthermore, preclinical clinical studies suggest used numerous disorders, This review aims summarize existing knowledge regarding biological properties EGCG, especially context cancer prophylaxis.
Язык: Английский
Процитировано
41
Pharmaceuticals, Год журнала: 2024, Номер 17(6), С. 692 - 692
Опубликована: Май 27, 2024
There are a wide variety of phytochemicals collectively known as polyphenols. Their structural diversity results in broad range characteristics and biological effects. Polyphenols can be found foods drinks, including fruits, cereals, tea, coffee. Studies both vitro vivo, well clinical trials, have shown that they possess potent antioxidant activities, numerous therapeutic effects, health advantages. Dietary polyphenols demonstrated the potential to prevent many problems, obesity, atherosclerosis, high blood sugar, diabetes, hypertension, cancer, neurological diseases. In this paper, protective effects mechanisms behind them investigated detail, citing most recent available literature. This review aims provide comprehensive overview current knowledge on role preventing managing chronic The cited publications derived from vitro, human-based studies trials. A more complete understanding these naturally occurring metabolites will pave way for development novel polyphenol-rich diet drug programs. This, turn, provides further evidence their benefits.
Язык: Английский
Процитировано
18
Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 20, 2025
Abstract Neurodegenerative diseases (NDs) are caused by progressive neuronal death and cognitive decline. Epigallocatechin 3-gallate (EGCG) is a polyphenolic molecule in green tea as neuroprotective agent. This review evaluates the therapeutic effects of EGCG explores molecular mechanisms that show its properties. protects neurons several ways, such lowering oxidative stress, stopping Aβ from aggregation together, changing cell signaling pathways, decreasing inflammation. Furthermore, it promotes autophagy improves mitochondrial activity, supporting survival. Clinical studies have demonstrated supplementation can reduce neurodegenerative biomarkers enhance function. provides insights into potential treating various NDs. reduces stress scavenging free radicals enhancing antioxidant enzyme aiding defense. It also abilities inhibiting toxicity peptides. changes important pathways like Nrf2, PI3K/Akt, MAPK, which necessary for survival, death, Additionally, has strong anti-inflammatory properties because inhibits microglial activation downregulates pro-inflammatory cytokines. function reducing increasing ATP synthesis, promoting biogenesis, neurons’ survival energy metabolism. In addition, triggers autophagy, cellular process breaks down recycles damaged proteins organelles, eliminating neurotoxic aggregates maintaining homeostasis. Moreover, holds significant promise an ND treatment, but future research should focus on bioavailability understanding long-term clinical effects. Future improving delivery settings. potentially be agent managing NDs, indicating need further research.
Язык: Английский
Процитировано
2
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(11), С. 6075 - 6075
Опубликована: Май 28, 2022
Autophagy is an evolutionarily conserved process for the degradation of redundant or damaged cellular material by means a lysosome-dependent mechanism, contributing to cell homeostasis and survival. plays multifaceted context-dependent role in cancer initiation, maintenance, progression; it has tumor suppressive absence disease upregulated cells meet their elevated metabolic demands. represents promising but challenging target treatment. Green tea widely used beverage with healthy effects on several diseases, including cancer. The bioactive compounds green are mainly catechins, epigallocatechin-gallate (EGCG) most abundant biologically active among them. In this review, evidence autophagy modulation anti-cancer induced EGCG treatment experimental models presented. Reviewed articles reveal that promotes cytotoxic often through inactivation PI3K/Akt/mTOR pathway, resulting apoptosis induction. pro-oxidant activity been postulated be responsible its effects. combination therapy chemotherapy drug, inhibits growth drug-induced pro-survival autophagy. selected studies rightly claim as valuable agent chemoprevention.
Язык: Английский
Процитировано
62
Critical Reviews in Food Science and Nutrition, Год журнала: 2023, Номер 64(19), С. 6546 - 6566
Опубликована: Фев. 2, 2023
Epigallocatechin gallate (EGCG), a typical flavone-3-ol polyphenol containing eight free hydroxyl groups, is associated with variety of bioactivities, such as antioxidant, anti-inflammatory, anti-cancer, and antibacterial activities. However, the poor bioavailability EGCG restricts its use. In this review, we discuss processes involved in absorption metabolism EGCG, focus on metabolic interactions gut microbiota. Next, summarize bioactivities some key metabolites, describe biotransformation by different microorganisms, catabolism specific bacteria. A deeper understanding absorption, metabolism, may enable disease-preventive therapeutic properties to be better utilized. This review provides theoretical basis for further development utilization metabolites improving microbiota physiological health.
Язык: Английский
Процитировано
31
Heliyon, Год журнала: 2024, Номер 10(2), С. e24207 - e24207
Опубликована: Янв. 1, 2024
High blood glucose levels are a hallmark of the metabolic syndrome known as diabetes mellitus. More than 600 million people will have by 2045 global prevalence disease continues to rise. Contemporary antidiabetic drugs reduce hyperglycemia and its consequences. However, these come with undesirable side effects, so it's encouraging that research into plant extracts bioactive substances characteristics is on Natural remedies preferable conventional anti-diabetic since they safer for body, more affordable fewer potential adverse effects. Biological macromolecules such liposomes, niosomes, polymeric nanoparticles, solid lipid nanoemulsions metallic nanoparticles explored in this review. Current drug restrictions been addressed, effectiveness plant-based therapies has enhanced merits methods. Plant extracts' loading capacity carriers' stability primary obstacles developing nanocarriers. Hydrophilic, hydrophobic, amphiphilic covered, brief overview amphipathic features phospholipids, nanocarriers provided. Metallic nanoparticles' benefits attendant risks highlighted emphasize their efficiency treating hyperglycemia. Researchers interested loaded therapeutics may find current helpful
Язык: Английский
Процитировано
10
Phytotherapy Research, Год журнала: 2024, Номер 38(6), С. 2993 - 3019
Опубликована: Апрель 10, 2024
Abstract Neurodegenerative disorders (NDs) are among the most common causes of death across globe. NDs characterized by progressive damage to CNS neurons, leading defects in specific brain functions such as memory, cognition, and movement. The Parkinson's, Alzheimer's, Huntington's, amyotrophic lateral sclerosis (ALS). Despite extensive research, no therapeutics or medications against have been proven be effective. current treatment involving symptom‐based targeting disease pathogenesis has certain limitations, drug resistance, adverse side effects, poor blood–brain barrier permeability, bioavailability drugs. Some studies shown that plant‐derived natural compounds hold tremendous promise for treating preventing NDs. Therefore, primary objective this review article is critically analyze properties potency some studied phytomedicines, quercetin, curcumin, epigallocatechin gallate (EGCG), apigenin, cannabinoids, highlight their advantages limitations developing next‐generation alternative treatments Further research on pre‐clinical clinical plant‐based drugs from bench bedside warranted.
Язык: Английский
Процитировано
10
Foods, Год журнала: 2024, Номер 13(8), С. 1232 - 1232
Опубликована: Апрель 17, 2024
Epigallocatechin gallate (EGCG), the key constituent of tea polyphenols, presents challenges in terms its lipid solubility, stability, and bioavailability because polyhydroxy structure. Consequently, structural modifications are imperative to enhance efficacy. This paper comprehensively reviews esterification techniques applied EGCG over past two decades their impacts on bioactivities. Both chemical enzymatic methods involve catalysts, solvents, hydrophobic groups as critical factors. Although method is cost-efficient, it poses purification; other hand, approach offers improved selectivity simplified purification processes. The biological functions inevitably influenced by changes incurred through esterification. antioxidant capacity derivatives can be compromised under certain conditions reducing hydroxyl groups, while enhancing solubility stability strengthen antiviral, antibacterial, anticancer properties. Additionally, broadens utility food applications. review provides insights into developing cost-effective environmentally sustainable selective methods, well emphasizes elucidation bioactive mechanisms facilitate widespread adoption processing, healthcare products, pharmaceuticals.
Язык: Английский
Процитировано
8