Recent insights into the nutritional immunomodulation of cancer‐related microRNAs

Phytotherapy Research, Год журнала: 2023, Номер 37(10), С. 4375 - 4397

Опубликована: Июль 11, 2023

Abstract Cancer is the most common cause of death worldwide, following cardiovascular diseases. a multifactorial disease and many reasons such as physical, chemical, biological, lifestyle‐related factors. Nutrition, which one various factors that play role in prevention, development, treatment types cancer, affects immune system, characterized by disproportionate pro‐inflammatory signaling cancer. Studies investigating molecular mechanisms this effect have shown foods rich bioactive compounds, green tea, olive oil, turmeric, soybean significant positively changing expression miRNAs involved regulation genes associated with oncogenic/tumor‐suppressing pathways. In addition to these foods, some diet models may change specific cancer‐related different ways. While Mediterranean has been anticancer effects, high‐fat diet, methyl‐restricted are considered negative effects. This review aims discuss effects called “immune foods,” models, components on cancer prevention

Язык: Английский

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Current Understanding of Polyphenols to Enhance Bioavailability for Better Therapies

Biomedicines, Год журнала: 2023, Номер 11(7), С. 2078 - 2078

Опубликована: Июль 24, 2023

In recent years, plant polyphenols have become a popular focus for the development of novel functional foods. Polyphenols, class bioactive compounds, including flavonoids, phenolic acids, and lignans, are commonly found in plant-based diets with variety biological actions, antioxidant, anti-inflammatory, anticancer effects. Unfortunately, not widely used nutraceuticals since many chemicals possess poor oral bioavailability. Thankfully, can be encapsulated transported using bio-based nanocarriers, thereby increasing their Polyphenols' limited water solubility low bioavailability limiting factors practical usage, but this issue resolved if suitable delivery vehicles developed encapsulating delivering polyphenolic compounds. This paper provides an overview study nanocarriers enhancement polyphenol bioavailability, as well summary health advantages prevention treatment several diseases.

Язык: Английский

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Current Understanding of Flavonoids in Cancer Therapy and Prevention

Metabolites, Год журнала: 2023, Номер 13(4), С. 481 - 481

Опубликована: Март 27, 2023

Cancer is a major cause of death worldwide, with multiple pathophysiological manifestations. In particular, genetic abnormalities, inflammation, bad eating habits, radiation exposure, work stress, and toxin consumption have been linked to cancer disease development progression. Recently, natural bioactive chemicals known as polyphenols found in plants were shown anticancer capabilities, destroying altered or malignant cells without harming normal cells. Flavonoids demonstrated antioxidant, antiviral, anticancer, anti-inflammatory effects. Flavonoid type, bioavailability, possible method action determine these biological actions. These low-cost pharmaceutical components significant activities are beneficial for several chronic disorders, including cancer. Recent research has focused primarily on isolating, synthesizing, studying the effects flavonoids human health. Here we attempted summarize our current knowledge flavonoids, focusing their mode better understand

Язык: Английский

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Chemistry, bioavailability, bioactivity, nutritional aspects and human health benefits of polyphenols: A comprehensive review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 277, С. 134223 - 134223

Опубликована: Июль 29, 2024

Язык: Английский

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Bioactive compound encapsulation: Characteristics, applications in food systems, and implications for human health

Food Chemistry X, Год журнала: 2024, Номер 24, С. 101953 - 101953

Опубликована: Ноя. 2, 2024

Nanotechnology plays a pivotal role in food science, particularly the nanoencapsulation of bioactive compounds, to enhance their stability, bioavailability, and therapeutic potential. This review aims provide comprehensive analysis encapsulation emphasizing characteristics, applications, implications for human health. work offers detailed comparison polymers such as sodium alginate, gum Arabic, chitosan, cellulose, pectin, shellac, xanthan gum, while also examining both conventional emerging techniques, including freeze-drying, spray-drying, extrusion, coacervation, supercritical anti-solvent drying. The contribution this lies highlighting improving system controlling release rates, maintaining bioactivity under extreme conditions, reducing lipid oxidation. Furthermore, it explores recent technological advances aimed at optimizing processes targeted therapies functional foods. findings underline significant potential not only supplements foods but supportive medical treatments, showcasing its relevance health various contexts.

Язык: Английский

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Biological potential and mechanisms of Tea’s bioactive compounds: An Updated review

Journal of Advanced Research, Год журнала: 2023, Номер 65, С. 345 - 363

Опубликована: Дек. 5, 2023

Tea (Camellia sinensis) has a rich history and is widely consumed across many countries, categorized into green tea, white oolong yellow black dark tea based on the level of fermentation. Based review previous literature, commonly recognized bioactive substances in include polyphenols, amino acids, polysaccharides, alkaloids, terpenoids, macro minerals, trace elements, vitamins, which have been known to various potential health benefits, such as anticancer, antioxidant, anti-inflammatory, anti-diabetes, anti-obesity properties, cardiovascular protection, immune regulation, control intestinal microbiota. Most studies only pointed out characteristics tea's bioactivities, so comprehensive summary pharmacological mechanisms bioactivities their use risks are vital. Review The aim this paper summarize mechanisms, providing scientific basis for application outlining future research directions study tea. Key Scientific Concepts This summarizes main biologically active substances, effects, discusses risks. It may help researchers grasp more progress further promote natural substance medical field.

Язык: Английский

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Resveratrol, Epigallocatechin Gallate and Curcumin for Cancer Therapy: Challenges from Their Pro-Apoptotic Properties

Life, Год журнала: 2023, Номер 13(2), С. 261 - 261

Опубликована: Янв. 17, 2023

Plant-derived bioactive compounds are gaining wide attention for their multiple health-promoting activities and in particular anti-cancer properties. Several studies have highlighted how they can prevent cancer initiation progression, improve the effectiveness of chemotherapy, and, some cases, limit side effects chemotherapy agents. In this paper, we provide an update literature on three extensively studied plant-derived compounds, namely resveratrol, epigallocatechin gallate, curcumin, with a special focus molecular mechanisms inducing apoptosis major types cancers globally.

Язык: Английский

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EGCG-based nanoparticles: synthesis, properties, and applications

Critical Reviews in Food Science and Nutrition, Год журнала: 2024, Номер unknown, С. 1 - 22

Опубликована: Март 22, 2024

(-)-Epigallocatechin-3-gallate (EGCG) is a natural phenolic substance found in foods and beverages (especially tea) that exhibits broad spectrum of biological activities, including antioxidant, antimicrobial, anti-obesity, anti-inflammatory, anti-cancer properties. Its potential cardiovascular brain health has garnered significant attention. However, its clinical application remains limited due to poor physicochemical stability low oral bioavailability. Nanotechnology can be used improve the stability, efficacy, pharmacokinetic profile EGCG by encapsulating it within nanoparticles. This article reviews interactions with various compounds, synthesis EGCG-based nanoparticles, functional attributes these their prospective applications drug delivery, diagnosis, therapy. The nanoencapsulated also emphasized. Top-down bottom-up approaches construct nanoparticles exhibit enhanced bioavailability compared free EGCG, making them promising candidates for biomedical food applications. Notably, non-covalent covalent other substances significantly contribute improved properties appear have wide range different industries, but further research required enhance efficacy ensure safety.

Язык: Английский

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Green Tea: Current Knowledge and Issues

Foods, Год журнала: 2025, Номер 14(5), С. 745 - 745

Опубликована: Фев. 22, 2025

Green tea possesses antioxidant, anti-inflammatory, anticancer, and antimicrobial activities, reduces body weight, slows down aging. These effects are primarily attributed to catechins contained in green leaves, particularly epigallocatechin-3-gallate. However, humans, the realization of tea's beneficial is limited. In order summarize critically analyze available scientific information about health benefits issues related its use, we conducted an in-depth literature review databases. A number vitro studies reported that modulate various signaling pathways cells, which thought underlie their effects. data on humans scarce, partly due low stability oral bioavailability. Furthermore, may also participate pharmacokinetic interactions when co-administered with certain drugs such as anticancer agents, for cardiovascular diseases, immunosuppressors, etc. As a result, adverse drug reactions or therapy failure occur. conclusion, over years, approaches have been investigated optimize catechin intake achieve but date, use prophylaxis disease treatment remains Therefore, future regarding possibilities administration needed.

Язык: Английский

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Consumption of Unsweetened Coffee or Tea May Reduce the Cancer Incidence and Mortality: A Prospective Cohort Study

Journal of Nutrition, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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