Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 858 - 858
Опубликована: Апрель 2, 2025
Background/Objectives:
Patients
with
central
nervous
system
injuries
who
are
hospitalized
in
intensive
care
units
(ICUs)
at
high
risk
for
nosocomial
infections.
Limited
data
available
on
the
incidence
and
patterns
of
microbial
colonization
infection
this
patient
population.
Methods:
To
fill
gap,
we
performed
an
electronic
health
record-based
study
1614
chronic
patients
brain
injury
admitted
to
ICU
from
2017
2023.
Results:
Among
infectious
complications,
pneumonia
was
most
common
(n
=
879;
54.46%).
Sepsis
diagnosed
54
patients,
whom
46
(85%)
were
pneumonia.
The
only
pathogen
that
showed
association
development
sepsis
colonized
Pseudomonas
aeruginosa
(pneumonia:
p
7.2
×
10−9;
sepsis:
1.7
10−5).
Bacterial
isolates
without
did
not
differ
titer
or
dynamics,
but
monomicrobial
culture
more
likely
develop
than
polymicrobial
(1
vs.
2
pathogens,
0.014;
1
+
pathogens
3
4
2.8
10−6),
although
lower
monoculture
polyculture.
all
sites
levels
multidrug
resistance
(Gram-negative
bacteria:
88–100%;
Gram-positive
48–97%),
no
differences
multidrug-resistant
organism
(MDRO)
rates.
Conclusions:
Our
results
highlight
burden
MDROs
neurological
ICUs
provide
novel
ecosystem-based
insights
into
mono-
development.
These
findings
may
be
useful
developing
strategies
protect
against
FEMS Microbiology Reviews,
Год журнала:
2022,
Номер
46(5)
Опубликована: Май 31, 2022
Abstract
The
microbial
world
represents
a
phenomenal
diversity
of
microorganisms
from
different
kingdoms
life,
which
occupy
an
impressive
set
ecological
niches.
Most,
if
not
all,
once
colonize
surface
develop
architecturally
complex
surface-adhered
communities,
we
refer
to
as
biofilms.
They
are
embedded
in
polymeric
structural
scaffolds
and
serve
dynamic
milieu
for
intercellular
communication
through
physical
chemical
signalling.
Deciphering
ecology
biofilms
various
natural
or
engineered
settings
has
revealed
coexistence
all
domains
including
Bacteria,
Archaea,
Eukarya.
these
microbes
is
arbitrary,
highly
coordinated
architectural
setup
physiological
complexity
show
interdependence
myriads
underlying
interactions.
In
this
review,
describe
how
species
interact
discuss
the
functional
consequences
such
We
highlight
metabolic
advances
collaboration
among
kingdoms,
advocate
that
interactions
great
importance
need
be
addressed
future
research.
Since
trans-kingdom
impact
diverse
contexts,
ranging
complicated
infections
efficient
growth
plants,
knowledge
within
field
will
beneficial
medical
microbiology,
biotechnology,
our
general
understanding
life
nature.
The
use
of
probiotics
has
been
one
the
effective
strategies
to
restructure
perturbed
human
gut
microbiota
following
a
disease
or
metabolic
disorder.
One
biggest
challenges
associated
with
probiotic-based
modulation
is
keep
probiotic
cells
viable
and
stable
during
gastrointestinal
transit.
Biofilm-based
delivery
approaches
have
emerged
as
fascinating
modes
in
which
show
significantly
greater
tolerance
biotherapeutic
potential,
interestingly
biofilms
can
be
developed
on
food-grade
surfaces
too,
ideal
for
growth
proliferation
bacterial
incorporation
into
food
matrices.
In
addition,
further
encapsulated
materials
self-produced
biofilms.
This
review
presents
newly
emerging
unprecedently
discussed
techniques
safe
based
discusses
prebiotic
target
specific
groups
proliferation.
Biofilm,
Год журнала:
2024,
Номер
7, С. 100195 - 100195
Опубликована: Апрель 8, 2024
Interspecies
interactions
within
a
biofilm
community
influence
population
dynamics
and
structure,
which
in
turn
may
affect
the
bacterial
stress
response
to
antimicrobials.
This
study
was
conducted
assess
impact
of
between
Foodborne Pathogens and Disease,
Год журнала:
2023,
Номер
20(2), С. 47 - 58
Опубликована: Фев. 1, 2023
Pseudomonas
aeruginosa
biofilm
formation
has
been
considered
to
be
an
important
determinant
of
its
pathogenicity
in
most
infections.
The
antibiofilm
activity
trans-cinnamaldehyde
(TC)
against
P.
was
investigated
this
study.
Results
demonstrated
that
the
minimum
inhibitory
concentration
(MIC)
TC
0.8
mg/mL,
and
subinhibitory
concentrations
(SICs)
0.2
mg/mL
below.
Crystal
violet
staining
showed
at
0.05–0.2
reduced
biomass
48
h
a
concentration-dependent
mode.
area
TC-treated
biofilms
significantly
declined
(p
<
0.01)
on
glass
slides
observed
by
light
microscopy.
Field-emission
scanning
electron
microscopy
further
destroyed
morphology
structure.
Confocal
laser
microscopic
dispersion
reduction
exopolysaccharides
after
treatment
stained
with
concanavalin
A
(Con-A)-fluorescein
isothiocyanate
conjugate
Hoechst
33258.
Meanwhile,
caused
significant
decrease
component
polysaccharides,
proteins,
DNA
extracellular
polymeric
substance.
swimming
swarming
motility
quorum
sensing
also
found
inhibited
SICs.
Furthermore,
SICs
repressed
several
genes
transcription
associated
as
determined
real-time
quantitative
polymerase
chain
reaction.
Overall,
our
findings
suggest
could
applied
natural
safe
agent
inhibit
aeruginosa.
