Novel Strategies in Breast Cancer Management: from Treatment to Long-term Remission

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104715 - 104715

Published: April 1, 2025

Language: Английский

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NDP@MnO₂ hydrogel combined with photothermal therapy for postoperative anti-recurrence treatment of pancreatic cancer

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Surgical resection remains a potentially curative treatment option for pancreatic cancer (PC). However, the high rate of local tumor recurrence and poor prognosis severely limit its therapeutic efficacy. In this study, we report an injectable thermosensitive hydrogel platform (designated as NDP@MnO₂ hydrogel) that exhibits excellent biocompatibility, photothermal performance, wet adhesion properties, specifically designed precise post-operative therapy. This system innovatively combines shear-thinning injectability, dopamine-mediated tissue adhesion, MnO₂-enhanced ablation capabilities. By precisely targeting hyperthermia to moist irregular margins during sol-gel transition subsequent exposure 808 nm laser, approach can effectively selectively eliminate residual cells while minimizing collateral damage adjacent healthy tissues. Notably, pre-clinical studies have demonstrated significantly reduces locoregional in models, thereby offering promising solution critical issue postoperative recurrence.

Language: Английский

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Poloxamer-based drug delivery systems: Frontiers for treatment of solid tumors

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101727 - 101727

Published: April 1, 2025

Pluronics or poloxamers are a type of triblock copolymer. These non-ionic molecules consist hydrophobic block embedded in two hydrophilic parts. have become favorite materials for use the field biomedical research due to having favorable physicochemical and biological properties such as amphiphilicity, solubility ionic solutions, biocompatibility, biodegradability, self-assembly low toxicity. The scope these applications can vary from tissue engineering drug delivery. One important uses pluronics is deliver drugs various cancer cells. Herein we first provide an overview on variety ploronic biomaterials. And then intensively evaluate their potential delivery systems (DDSs) treatment solid tumors with special focus breast cancers. After explaining pros cons pluronics, current status clinical settings future prospects highlighted.

Language: Английский

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Carrageenan‐Based Hydrogels for Advanced Wound Healing and Controlled Drug Delivery in Tissue Engineering

Journal of Biomedical Materials Research Part B Applied Biomaterials, Journal Year: 2025, Volume and Issue: 113(5)

Published: May 1, 2025

ABSTRACT Carrageenan (CGN) is a high molecular weight polysaccharide that extracted from red seaweeds. It made up of D‐galactose residues connected by β‐1,4 and α‐1,3 galactose‐galactose bonds. As result its ability to thicken, emulsify, stabilize food, it frequently used as food additive in processed food. Its consumption has surged recent years due the Western diet's (WD) spread. change thickness mucus barrier, composition gut microbiota, innate immune pathway causes inflammation. Also, inherent qualities, which include biodegradability, biocompatibility, resemblance native glycosaminoglycans, antioxidants, anticancer, immunomodulatory, anticoagulant activities, Carrageenan‐based hydrogels have been subject numerous investigations lately for biomedical applications. The brittle hydrogel uncontrollably exchanged ions, however, are two drawbacks application this polysaccharide, but these can be avoided making straightforward chemical changes polymer networks, create chemically bonded with important mechanical characteristics regulated degradation rates. Furthermore, addition diverse kinds nanoparticles, well carrageenan results hybrid platforms noteworthy mechanical, chemical, biological characteristics, qualify them appropriate biomaterials tissue engineering (TE), drug delivery (DD), also wound healing Our goal article provide an overview most current developments carrageenan‐based several modification techniques TE DD

Language: Английский

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Research progress of paclitaxel nanodrug delivery system in the treatment of triple-negative breast cancer

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101358 - 101358

Published: Nov. 23, 2024

Language: Английский

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