Ganoderma lucidum polysaccharide hydrogel accelerates diabetic wound healing by regulating macrophage polarization

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 260, С. 129682 - 129682

Опубликована: Янв. 22, 2024

Язык: Английский

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A review of polysaccharides from Ganoderma lucidum: Preparation methods, structural characteristics, bioactivities, structure-activity relationships and potential applications

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140645 - 140645

Опубликована: Фев. 1, 2025

Язык: Английский

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Recent Advances in the Preparation, Structure, and Biological Activities of β-Glucan from Ganoderma Species: A Review

Foods, Год журнала: 2023, Номер 12(15), С. 2975 - 2975

Опубликована: Авг. 7, 2023

has served as a valuable food supplement and medicinal ingredient with outstanding active compounds that are essential for human protection against chronic diseases. Modern pharmacology studies have proven

Язык: Английский

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Ganoderma lucidum polysaccharide ameliorates cholesterol gallstone formation by modulating cholesterol and bile acid metabolism in an FXR-dependent manner

Chinese Medicine, Год журнала: 2024, Номер 19(1)

Опубликована: Янв. 24, 2024

Abstract Background Cholesterol gallstone (CG) disease is a worldwide common characterized by cholesterol supersaturation in gallbladder bile. Ganoderma lucidum polysaccharide (GLP) has been shown to possess various beneficial effects against metabolic disorders. However, the role and underlying mechanism of GLP CG formation are still unknown. This study aimed determine ameliorating lithogenic diet (LD)-induced formation. Methods Mice were fed either normal chow diet, LD, or LD supplemented with GLP. Real-time quantitative polymerase chain reaction (RT-qPCR) western blotting used detect expression genes involved bile acid (BA) metabolism. The BA concentrations ileum quantified liquid chromatography-tandem mass spectrometry (LC–MS/MS). microbiota cecal contents using 16S ribosomal RNA (16S rRNA) gene sequencing. Results effectively alleviated induced LD. Specifically, reduced total (TC) levels, increased decreased saturation index (CSI) protective effect was attributed inhibition farnesoid X receptor (FXR) signaling, hepatic synthesis secretion. also altered composition ileum, reducing FXR-agonistic BAs increasing FXR-antagonistic BAs, which may contribute intestinal FXR signaling. Additionally, improved dysbiosis flora serum levels hydrogen sulfide (H 2 S), bacterial metabolite that can induce FXR, thereby inhibiting Moreover, could be reversed both global gut-restricted agonists. Conclusions Taken together, ameliorates regulating metabolism an FXR-dependent manner. Our demonstrates potential strategy for prevention disease.

Язык: Английский

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The Isolation, Structural Characterization and Anti-Inflammatory Potentials of Neutral Polysaccharides from the Roots of Isatis indigotica Fort

Molecules, Год журнала: 2024, Номер 29(11), С. 2683 - 2683

Опубликована: Июнь 5, 2024

Polysaccharides have been assessed as a potential natural active component in Chinese herbal medicine with anti-inflammatory properties. However, the complex and indefinite structures of polysaccharides limit their applications. This study explains potentials three neutral polysaccharides, RIP-A1 (M

Язык: Английский

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Anti-inflammatory properties of polysaccharides from edible fungi on health-promotion: a review

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июль 26, 2024

Edible fungus polysaccharides have garnered significant attention from scholars due to their safety and potential anti-inflammatory activity. However, comprehensive summaries of properties are still rare. This paper provides a detailed overview the effects mechanisms these polysaccharides, as well impact on inflammation-related diseases. Additionally, relationship between structure activity is discussed. It believed that this review will greatly enhance understanding application edible in treatments, thereby significantly promoting development utilization fungi.

Язык: Английский

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Extraction, purification, structural characterization, biological activity, mechanism of action and application of polysaccharides from Ganoderma lucidum: A review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138575 - 138575

Опубликована: Дек. 1, 2024

Язык: Английский

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Research progress on structural characterization and bioactivities of Poria cocos and Ganoderma polysaccharides

Food & medicine homology., Год журнала: 2024, Номер 2(1), С. 9420040 - 9420040

Опубликована: Сен. 18, 2024

Язык: Английский

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Ganoderma Lucidum Polysaccharides: A Comprehensive Overview of Pharmacological Effects and Future Perspectives

Food Bioscience, Год журнала: 2025, Номер unknown, С. 105990 - 105990

Опубликована: Янв. 1, 2025

Язык: Английский

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Predictive value and mechanism of lncRNA MANCR for pediatric severe pneumonia via miR-20a-5p / MAPK1 axis

Immunobiology, Год журнала: 2025, Номер 230(2), С. 152871 - 152871

Опубликована: Янв. 22, 2025

Язык: Английский

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