Sense of loneliness and meaning in life in chronic obstructive pulmonary disease patients. Preliminary studies. DOI Creative Commons
Kasper Sipowicz, Tadeusz Pietras, Michał Sobstyl

и другие.

Multidisciplinary Respiratory Medicine, Год журнала: 2024, Номер 19(Vol. 19 (2024))

Опубликована: Ноя. 12, 2024

Background: Chronic obstructive pulmonary disease (COPD) interferes with everyday functioning but its impact on the loneliness and meaning in life of patients is unclear. Objectives: to determine whether COPD severity levels correlate sense dimensions life. Methods: 144 during a period absence an infectious exacerbation were examined. The number exacerbations over past year, Modified Medical Research Council (mMRC) dyspnea score, Assessment Test (CAT) score determined as well feelings using De Jong Gierveld Loneliness Scale (DJGLS) Life Attitude Profile-Revised (LAP-R) questionnaire. Results: age, mMRC CAT scores, pack/years, year correlated positively feeling loneliness. These variables (except for age) negatively LAP-R scales apart from Existential Vacuum, which positively. subjects group D (the most seriously ill people) had highest level loneliness, while it was lowest A least people). No statistical difference observed between groups B C. Conclusions: With increase values selected parameters determining decreases intensifies.

Язык: Английский

Adrenergic regulation of immune cell function and inflammation DOI Open Access
Drashya Sharma, David J. Farrar

Seminars in Immunopathology, Год журнала: 2020, Номер 42(6), С. 709 - 717

Опубликована: Ноя. 20, 2020

Язык: Английский

Процитировано

123
Asthma-COPD Overlap DOI
Clarus Leung, Don D. Sin

CHEST Journal, Год журнала: 2021, Номер 161(2), С. 330 - 344

Опубликована: Окт. 7, 2021

Язык: Английский

Процитировано

38
Inhaled long-acting muscarinic antagonists in asthma – A narrative review DOI Creative Commons
Alberto Papi, Leonardo M. Fabbri, Huib A.M. Kerstjens

и другие.

European Journal of Internal Medicine, Год журнала: 2021, Номер 85, С. 14 - 22

Опубликована: Фев. 7, 2021

Long-acting muscarinic antagonists (LAMAs) have a recognised role in the management of chronic obstructive pulmonary disease. In asthma, (both short- and long-acting) were historically considered less effective than β2-agonists; only relatively recently studies been conducted to evaluate efficacy LAMAs, as add-on either inhaled corticosteroid (ICS) monotherapy or ICS/long-acting β2-agonist (LABA) combinations. These led approval first LAMA, tiotropium, an therapy patients with poorly controlled asthma. Subsequently, number single-inhaler ICS/LABA/LAMA triple therapies approved are clinical development for There is now substantial evidence safety LAMAs asthma that uncontrolled despite treatment ICS/LABA combination. This regimen recommended by GINA optimisation step severe before any biologic systemic initiated.This narrative review summarises potential mechanisms action together initial supporting this use. We also discuss tiotropium data evaluating various therapies, considering other uses therapy.

Язык: Английский

Процитировано

29
The concept of Big Four: Road map from snakebite epidemiology to antivenom efficacy DOI

Gayathri Gopal,

Shibi Muralidar,

Diwahar Prakash

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 242, С. 124771 - 124771

Опубликована: Май 9, 2023

Язык: Английский

Процитировано

12
The Mediation of Circulating Inflammatory Proteins in the Causal Pathway from Immune Cells to COPD DOI Creative Commons
Keqiang Yan, Yingjian Wang,

Peng Xin

и другие.

International Journal of COPD, Год журнала: 2025, Номер Volume 20, С. 245 - 257

Опубликована: Фев. 1, 2025

Objective: Observational studies have indicated that immune cells and circulating inflammatory proteins may play a dual role in the progression of COPD; however, precise mechanisms remain uncertain. The objective this study was to ascertain causal relationship between COPD quantify potential as mediators. Methods: A two-sample Mendelian randomisation analysis conducted involving 731 cells, 91 COPD, utilising summary-level data from genome-wide association studies. relationships were sequentially analysed by multivariate validated using Bayesian weighted randomisation. Subsequently, sensitivity analyses conducted, employing Cochran's Q test assess heterogeneity, MR-PRESSO MR-Egger tests pleiotropy, reverse MR Steiger directionality rule out causality. Lastly, two-step approach employed proportion mediate cell-mediated effects COPD. Results: combination inverse variance weighting method algorithm identified 30 found be causally associated with well eight By analysis, six cell phenotypes on CXCL10 having highest percentage mediation at 14.49%, followed IL20RA 11.47%. Conclusion: This provides comprehensive investigation an estimation effect These findings facilitate identification individuals high risk offer novel insights for early prevention clinical intervention. Keywords: randomization, proteins,

Язык: Английский

Процитировано

0
The impact of sensitization patterns on COPD severity and exacerbations: Insights from a case-control and longitudinal study DOI
Meropi Karakioulaki,

Caroline Berkemeier,

Leticia Grize

и другие.

European Journal of Internal Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
New Avenues for Phosphodiesterase Inhibitors in Asthma DOI Creative Commons
Maria Gabriella Matera, Josuel Ora, Francesco Cavalli

и другие.

Journal of Experimental Pharmacology, Год журнала: 2021, Номер Volume 13, С. 291 - 302

Опубликована: Март 1, 2021

Introduction: Phosphodiesterases (PDEs) are isoenzymes ubiquitously expressed in the lungs where they catalyse cyclic adenosine monophosphate (cAMP) and guanosine (GMP), which fundamental second messengers asthma, thereby regulating intracellular concentrations of these nucleotides, their signaling pathways and, consequently, myriad biological responses. The superfamily PDEs is composed 11 families with a distinct substrate specificity, molecular structure subcellular localization. Experimental studies indicate possible role asthma mainly for PDE3, PDE4, PDE5 PDE7. Consequently, drugs that inhibit may offer novel therapeutic options treatment this disease. Areas Covered: In article, we describe progress made recent years regarding possibility using PDE inhibitors asthma. Expert Opinion: Many data potential benefits as an add-on especially severe due to bronchodilator and/or anti-inflammatory activity, but no compound has yet reached market because limited tolerability. Therefore, there growing interest developing new improved safety profile. particular, research focused on development capable interacting simultaneously different PDEs, or be administered by inhalation. CHF 6001 RPL554 only molecules currently under clinical several agents interesting pharmacological profiles. It will stimulating assess impact such individual treatable traits specially designed studies. Keywords: phosphodiesterases, phosphodiesterase inhibitors, bifunctional drugs, approach

Язык: Английский

Процитировано

26
Phosphodiesterase isoforms and cAMP compartments in the development of new therapies for obstructive pulmonary diseases DOI
Martina Schmidt, Isabella Cattani‐Cavalieri,

Francisco Núñez

и другие.

Current Opinion in Pharmacology, Год журнала: 2020, Номер 51, С. 34 - 42

Опубликована: Апрель 1, 2020

Язык: Английский

Процитировано

24
Actualización de la Guía Española de la EPOC (GesEPOC): comorbilidades, automanejo y cuidados paliativos DOI
José Luis López‐Campos, Pere Almagro, José-Tomás Gómez

и другие.

Archivos de Bronconeumología, Год журнала: 2021, Номер 58(4), С. 334 - 344

Опубликована: Сен. 4, 2021

Язык: Английский

Процитировано

20
Role of CD4+ T and CD8+ T Lymphocytes-Mediated Cellular Immunity in Pathogenesis of Chronic Obstructive Pulmonary Disease DOI Creative Commons

Weilin Xue,

Jianying Ma,

Yue Li

и другие.

Journal of Immunology Research, Год журнала: 2022, Номер 2022, С. 1 - 9

Опубликована: Июнь 22, 2022

This work was to explore the changes of T lymphocyte subsets in peripheral blood patients with acute exacerbation chronic obstructive pulmonary disease (COPD) (AECOPD) and role cellular immunity mediated process. Eighty-six AECOPD who visited Qingdao Hiser Medical Center from June 2020 December 2021 30 healthy people (controls) underwent health examination same period were selected. The differences function (PF), arterial gas (ABG), routine inflammatory indexes, compared between two groups, correlation each index analyzed. There clear PF, ABG, PB inflammation indexes controls (P <0.05). Compared controls, CD4+ CD4+/CD8+ ratio group obviously decreased, CD8+ level clearly increased <0.05); Th1 cell Tc1 significantly increased, while Th2 Tc2 decreased However, positively correlated lung negatively neutrophils/lymphocytes high-sensitivity C-reactive protein <0.05) Hs-CRP In summary, lymphocytes involved occurrence AECOPD, decrease increase may promote deterioration COPD.

Язык: Английский

Процитировано

14