Immunology and Allergy Clinics of North America, Год журнала: 2022, Номер 42(3), С. 691 - 700
Опубликована: Июнь 30, 2022
Язык: Английский
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Апрель 6, 2024
Abstract There are few studies on the relationship between dietary habits and asthma–COPD overlap (ACO). In this study, we aimed to investigate association inflammation index (DII) score ACO. Data from National Health Nutrition Examination Survey (NHANES) 1999 2020. The DII was first calculated demographic characteristics of grouping based quartile were assessed. weighted logistic regression model used study Subgroup analysis further explore differences in different subgroups. Restricted cubic spline (RCS) plot show general trend disease risk, threshold effect determine inflection point. a comparison baseline characteristics, highest ACO prevalence found fourth array people DII. An adjusted showed that positively correlated with incidence more pronounced women, non-Hispanics, cardiovascular disease, without diabetes. RCS graph shows overall, risk increases increase score. Threshold point 3.779, significant after greater than value (OR 2.001, 95% CI 1.334–3.001, P < 0.001). Higher scores associated risk. These results support diet as an intervention strategy for prevention treatment.
Язык: Английский
Процитировано
7
Allergologie select, Год журнала: 2024, Номер 8(01), С. 90 - 198
Опубликована: Янв. 1, 2024
None.
Процитировано
7
Pneumologie, Год журнала: 2024, Номер 78(10), С. 693 - 784
Опубликована: Фев. 9, 2024
This article is an abridged version of the updated AWMF mould guideline "Medical clinical diagnostics in case indoor exposure - Update 2023", presented July 2023 by German Society Hygiene, Environmental Medicine and Preventive (Gesellschaft für Umweltmedizin und Präventivmedizin, GHUP), collaboration with Austrian scientific medical societies, experts. Indoor growth a potential health risk, even if quantitative and/or causal relationship between occurrence individual species problems has yet to be established. There no evidence for moisture/mould damage human diseases, mainly because ubiquitous presence fungi hitherto inadequate diagnostic methods. Sufficient association following effects been established for: allergic respiratory rhinitis, rhino-conjunctivitis, bronchopulmonary aspergillosis (ABPA), other mycosis (ABPM), aspergilloma, Aspergillus bronchitis, asthma (manifestation, progression, exacerbation), bronchitis (acute, chronic), community-acquired pneumonia, hypersensitivity pneumonitis (HP; extrinsic alveolitis (EEA)), invasive Aspergillosis, mycoses, organic dust toxic syndrome (ODTS) [workplace exposure], promotion infections, pulmonary (subacute, rhinosinusitis chronically invasive, or granulomatous, allergic). In this context sensitizing moulds obviously low compared environmental allergens. Recent studies show comparatively sensitization prevalence 3-22,5 % general population across Europe. Limited suspected exist respect atopic eczema (atopic dermatitis, neurodermatitis; manifestation), chronic obstructive disease (COPD), mood disorders, mucous membrane irritation (MMI), odor effects, sarcoidosis. (iv) Inadequate insufficient acute idiopathic hemorrhage infants, airborne transmitted mycotoxicosis, arthritis, autoimmune cancer, fatigue (CFS), endocrinopathies, gastrointestinal multiple chemical sensitivity (MCS), sclerosis, neuropsychological neurotoxic renal reproductive rheumatism, sick building (SBS), sudden infant death syndrome, teratogenicity, thyroid urticaria.The risk infection posed regularly occurring indoors healthy persons; most are group 1 few 2 (
Язык: Английский
Процитировано
6
Journal of Personalized Medicine, Год журнала: 2022, Номер 12(5), С. 708 - 708
Опубликована: Апрель 28, 2022
The term asthma-COPD overlap (ACO) has been used to identify a heterogeneous condition in which patients present with airflow limitation that is not completely reversible and clinical inflammatory features of both asthma chronic obstructive pulmonary disease (COPD). ACO diagnosis may be difficult practice, while controversy still exists regarding its definition, pathophysiology, impact. Patients experience greater burden compared or COPD alone, but contrast they show better response inhaled corticosteroid treatment than other phenotypes. Current management recommendations focus on defining specific measurable treatable traits, according phenotypes underlying biological mechanisms for every single patient. In this publication, we review the current knowledge characteristics, options ACO.
Язык: Английский
Процитировано
24
PLoS ONE, Год журнала: 2022, Номер 17(11), С. e0276774 - e0276774
Опубликована: Ноя. 1, 2022
Introduction The prevalence of asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap (ACO) in patients with COVID-19 varies, as well their risks mortality. present study aimed to assess the COPD, ACO comorbidities, determine mortality using a systematic review meta-analysis. Methods We systematically reviewed clinical studies that reported comorbidities COVID-19. searched various databases including PubMed (from inception 27 September 2021) for eligible written English. A meta-analysis was performed random-effect model measuring risk estimated. stratified analysis conducted according country. Results One hundred one were eligible, 1,229,434 identified. Among them, estimated 10.04% (95% confidence interval [CI], 8.79–11.30), 8.18% CI, 7.01–9.35), 3.70% 2.40–5.00), respectively. odds ratio pre-existing asthma 0.89 0.55–1.4; p = 0.630), while COPD 3.79 2.74–5.24; <0.001). France showed highest followed by UK, Netherlands India. Conclusion Pre-existing are associated incidence Having significantly increases These differences appear be influenced difference locations pathophysiology daily diagnosis treatment policy each
Язык: Английский
Процитировано
20
BMJ Open Respiratory Research, Год журнала: 2023, Номер 10(1), С. e001713 - e001713
Опубликована: Июнь 1, 2023
Background Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a condition characterised by the simultaneous presence of features both asthma and COPD. The study aims to investigate association between ACO frailty among middle-aged elderly populations, identify risk factors for in individuals with ACO. Methods We conducted cross-sectional 34 403 eligible participants (aged ≥40 years) from National Health Nutrition Examination Survey 1999–2018 cycles. Participants were stratified into four groups: ACO, asthma, COPD non-asthma/COPD. Frailty assessment was based on index, generating frail non-frail group. Univariate multivariate survey-weighted logistic regression analysis used determine frailty, Results prevalence 60.2%, significantly higher than that those (32.3%) (40.6%). In unadjusted model, exhibited six-fold odds (OR 6.30, 95% CI 5.29 7.49), which greater 2.84, 2.46 3.28) 1.99, 1.80 2.18), using non-asthma/COPD group as reference. After adjusting all confounders, had over times 4.48, 3.53 5.71), still findings remained robust sensitivity subgroup analyses. Furthermore, hypertension, cancer, cardiovascular disease, chronic kidney cognitive disorders identified participants, while income education levels protective factors. Conclusion Patients at regardless age or sex, compared alone. Greater attention should be paid patients their age.
Язык: Английский
Процитировано
12
BMC Public Health, Год журнала: 2024, Номер 24(1)
Опубликована: Май 28, 2024
Abstract Background Asthma-COPD overlap (ACO) is a distinct and intricate respiratory condition that requires specific attention management. The objective of this cohort study was to examine the epidemiological characteristics ACO, explore association between ACO all-cause mortality, investigate potential mediating role depressive symptoms in association. Methods This retrospective used data from National Health Nutrition Examination Survey (NHANES) 2005–2018 Death Index (NDI) 2019. A total 22,745 participants were included: 705 with 2352 asthma-only, 853 COPD-only, 18,835 without asthma or COPD. non-ACO group ( N = 22,040) referred individuals ACO. Statistical tests employed assess differences some other groups. Cox proportional hazards models applied evaluate relationship estimating hazard ratios (HR) 95% confidence intervals. Mediation analysis conducted effects on mortality. Results prevalence 3.10% our population. Compared participants, exhibited significantly different characteristics, including higher age, lower family income-to-poverty ratio, body mass index, rates comorbidities i.e., hypertension, diabetes, hyperlipidemia, cardiovascular disease, cancer, poorer dietary habits, rate disorders. significant increase mortality (HR 1.908, 95%CI 1.578–1.307, p < 0.001). proportions mediated by for -associated 8.13% (CI: 4.22%-14.00%, Conclusions revealed strong uncovered psychological mechanism underlying relationship. Our indicates possible necessity offering comprehensive care patients, encompassing early detection, lifestyle guidance, mental health support. Nevertheless, due limitations design dataset, results should be interpreted caution.
Язык: Английский
Процитировано
4
International Journal of COPD, Год журнала: 2025, Номер Volume 20, С. 1051 - 1060
Опубликована: Апрель 1, 2025
This study aimed to evaluate changes in the prevalence of Asthma-COPD Overlap (ACO) among patients with Acute Exacerbations COPD (AECOPD) from 2019 2023. It also compared clinical characteristics across EOS thresholds (50, 150, and 300 cells/μL) identify disease severity markers guide individualized treatment strategies. Clinical data AECOPD ACO hospitalized at Second Hospital Hebei Medical University between January December 2023 were analyzed. Patients grouped by levels cells/μL), their compared. Among 408 275 patients, during late pandemic period was significantly higher than pre-pandemic 2019. showed increased counts FeNO (P < 0.05). In those <50 cells/μL had lower lymphocyte NLR FDP other groups. Similarly, group levels. ≥300 younger exhibited 50-150 groups <0.05). The period, possibly indicating a role for type 2 inflammation. 50, may serve as aid tailoring
Язык: Английский
Процитировано
0
Respiratory Research, Год журнала: 2024, Номер 25(1)
Опубликована: Апрель 13, 2024
Abstract Background Longitudinal studies have identified childhood asthma as a risk factor for obstructive pulmonary disease (COPD) and asthma-COPD overlap (ACO) where persistent airflow limitation can develop more aggressively. However, causal link between COPD/ACO remains to be established. Our study aimed model the natural history of COPD investigate cellular/molecular mechanisms that drive progression. Methods Allergic airways was established in three-week-old young C57BL/6 mice using house dust mite (HDM) extract. Mice were subsequently exposed cigarette smoke (CS) HDM 8 weeks. Airspace enlargement (emphysema) measured by mean linear intercept method. Flow cytometry utilised phenotype lung immune cells. Bulk RNA-sequencing performed on tissue. Volatile organic compounds (VOCs) bronchoalveolar lavage-fluid analysed screen disease-specific biomarkers. Results Chronic CS exposure induced emphysema significantly augmented challenge. Increased emphysematous changes associated with abundant cell infiltration consisting neutrophils, interstitial macrophages, eosinophils lymphocytes. Transcriptomic analyses gene signature or alone conserved HDM-CS group, further revealed an enrichment Mmp12 , Il33 Il13 expression consistent greater expansion alternatively activated macrophages. VOC analysis also four increased paradoxically reduced group. Conclusions Early-life allergic worsened pathology CS-exposed markedly alters transcriptome.
Язык: Английский
Процитировано
3
Clinical Immunology, Год журнала: 2022, Номер 237, С. 108986 - 108986
Опубликована: Март 26, 2022
Язык: Английский
Процитировано
11