Chemotherapy-Mediated Neuronal Aberration

Pharmaceuticals, Год журнала: 2023, Номер 16(8), С. 1165 - 1165

Опубликована: Авг. 16, 2023

Chemotherapy is a life-sustaining therapeutic option for cancer patients. Despite the advancement of several modern therapies, such as immunotherapy, gene therapy, etc., chemotherapy remains first-line therapy most Along with its anti-cancerous effect, exhibits detrimental consequences that restrict efficacy and long-term utilization. Moreover, it effectively hampers quality life Cancer patients receiving chemotherapeutic drugs suffer from neurological dysfunction, referred to chemobrain, includes cognitive memory dysfunction deficits in learning, reasoning, concentration ability. neurotoxicity by damaging DNA neurons interfering repair system antioxidant machinery. In addition, also provokes inflammation inducing release various pro-inflammatory cytokines, including NF-kB, IL-1β, IL-6, TNF-α. The chemotherapy-mediated contributes chemobrain These inflammatory cytokines modulate growth signaling pathways reactive oxygen species homeostasis leading systemic body. This review an effort summarize available information which discusses role chemotherapy-induced how impacts different aspects outcome overall patient. Further, this article potential herbal-based remedies overcome neuronal toxicity well improve

Язык: Английский

---

LC-qTOF-MS/MS phytochemical profiling of Tabebuia impetiginosa (Mart. Ex DC.) Standl. leaf and assessment of its neuroprotective potential in rats

Journal of Ethnopharmacology, Год журнала: 2024, Номер 331, С. 118292 - 118292

Опубликована: Май 3, 2024

Язык: Английский

---

Postoperative acute pain challenges in patients with cancer

Best Practice & Research Clinical Anaesthesiology, Год журнала: 2019, Номер 33(3), С. 361 - 371

Опубликована: Июль 27, 2019

Язык: Английский

---

Oroxylum Indicum ameliorates chemotherapy induced cognitive impairment

PLoS ONE, Год журнала: 2021, Номер 16(6), С. e0252522 - e0252522

Опубликована: Июнь 3, 2021

While chemotherapy is the most effective therapeutic approach for treating a variety of cancer patients, commonly used chemotherapeutic agents, often induce several adverse effects. Escalating evidence indicates that chemotherapeutics, particularly doxorubicin (DOX) and cyclophosphamide (CPS), cognitive impairment associated with central nervous system toxicity. This study was performed to determine neuroprotective effects Oroxylum indicum extract (OIE) in regard preventing induced (CICI) occurring after 4 cycles DOX (2mg/kg) CPS (50mg/kg) combination male C57BL/6J mice. OIE significantly prevented impaired short-term performance, exploratory behavior spatial learning memory Y-maze, Open-Field, Novel Object Recognition, Morris Water Maze tests, respectively. These data suggest protects from CICI. decreased reactive oxygen species lipid peroxide generated by treatment brain, while also blocking chemotherapy-induced glutathione depletion. results establish exhibits potent antioxidant activity treated Notably, increased Complex-I Complex-IV activities indicating enhances mitochondrial function brain. In silico analysis major active chemical constituents (Oroxylin A, Baicalein Chrysin) indicated has favorable absorption, distribution, metabolism excretion (ADME) profile. Taken together, our are consistent conclusion prevents CICI counteracting oxidative stress perhaps improving function.

Язык: Английский

---

Glioblastoma Multiforme Selective Nanomedicines for Improved Anti-Cancer Treatments

Pharmaceutics, Год журнала: 2022, Номер 14(7), С. 1450 - 1450

Опубликована: Июль 12, 2022

Glioblastoma Multiforme (GBM) is a devastating disease with low survival rate and few efficacious treatment options. The fast growth, late diagnostics, off-target toxicity of currently used drugs represent major barriers that need to be overcome provide viable cure. Nanomedicines (NMeds) offer way these pitfalls by protecting loading drugs, increasing blood half-life, being targetable specific ligands on their surface. In this study, the FDA-approved polymer poly (lactic-co-glycolic) acid was optimise NMeds were surface modified series potential GBM-specific ligands. fully characterised for physical chemical properties, then in vitro testing performed evaluate cell uptake GBM specificity. While all targeted showed improved uptake, only those decorated the-cell vimentin antibody M08 specificity over healthy cells. Finally, most promising NMed candidate loaded well-known chemotherapeutic, paclitaxel, confirm targeting therapeutic effects C6 These results demonstrate importance using well-optimised novel advance delivery pharmaceutical against diseased cells while minimising risk nearby

Язык: Английский

---

Investigating brain cortical activity in patients with post-COVID-19 brain fog

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Фев. 9, 2023

Brain fog is a kind of mental problem, similar to chronic fatigue syndrome, and appears about 3 months after the infection with COVID-19 lasts up 9 months. The maximum magnitude third wave in Poland was April 2021. research referred here aimed at carrying out investigation comprising electrophysiological analysis patients who suffered from had symptoms brain (sub-cohort A), did not have B), control group that no C). aim this article examine whether there are differences cortical activity these three sub-cohorts and, if possible differentiate classify them using machine-learning tools. he dense array electroencephalographic amplifier 256 electrodes used for recordings. event-related potentials were chosen as we expected find patients' responses different tasks arranged experiments commonly known experimental psychology: face recognition, digit span, task switching. These plotted all experiments. cross-correlation method differences, fact, such manifested themselves shape on cognitive electrodes. discussion will be presented; however, an explanation would require recruitment much larger cohort. In classification avalanche feature extractions resting state signal linear discriminant used. between signals found. Machine-learning tools used, finding eyes seemed impossible. Indeed, A&B vs. C, B&C A, A B, B C performed, efficiency around 60–70% achieved. future, probably pandemics again due imbalance natural environment, resulting decreasing number species, temperature increase, climate change-generated migrations. can help predict recovery prepare better convalescence. Shortening time beneficial only but also social conditions.

Язык: Английский

---

Patients’ perspectives of the skills and competencies of therapy radiographers/radiation therapists (TRs/RTTs) in the UK, Portugal and Malta; a qualitative study from the SAFE Europe project

Radiography, Год журнала: 2023, Номер 29, С. S117 - S127

Опубликована: Март 21, 2023

IntroductionThe role of the Therapy Radiographer/Radiation Therapist (TR/RTT) is to provide radiotherapy patients with a cancer diagnosis. This includes, not only administration treatment, but also management side-effects and provision support/care. Despite this being consistent throughout Europe, there currently no standardisation education for TRs/RTTs. The SAFE EUROPE project aims standardize TR/RTT enable 'safe free exchange' TRs/RTTs across Europe. Consequently, study explore patients' perspectives regarding current skills competencies TRs/RTTs.MethodsFrom May 2021 February 2022, semi-structured interviews were conducted who had recently received in UK, Malta Portugal. Ethical approval was granted by NHS Research Ethics Committee additional local approvals obtained.ResultsForty-eight participants from UK (n = 18), Portugal 19), 11) completed interviews. Participants described high satisfaction TRs'/RTTs' competence all three countries. main theme arising analysis importance trust building Six factors identified as influencing levels trust: communication; side-effect management; team consistency; relational skills; patient dignity; competence. A small number reported feeling rushed having their physical emotional needs met TRs/RTTs.ConclusionThis multicentre demonstrated that perceive highly competent skilled. Practical recommendations are provided address deficits practice, which can be addressed through adaptation education/training clinical practice.Implications practiceRecommendations important ensure have transferable consistently quality care

Язык: Английский

---

Understanding the Experience and Impacts of Brain Fog in Chronic Pain: A Scoping Review

Canadian Journal of Pain, Год журнала: 2023, Номер 7(1)

Опубликована: Май 24, 2023

Approximately 15% to 40% of persons with chronic pain as a primary disorder experience brain fog. Prior research has investigated the etiology "brain fog" in conditions which presents key feature (e.g., fibromyalgia). However, it remains understudied context 10 musculoskeletal pain. Following current scoping review guidelines, we obtained stakeholder input from patient and health care professionals (HCPs) define this phenomenon. Specific aims were (1) identify factors contributing fog, (2) functional correlates fog assessments used measure them, (3) establish definition that can be employed by researchers HCPs advance care.A was conducted using recommendations Joanna Briggs Institute methodology reviews Levac et al methodology. Embase, Cinahl, PsycINFO, Medline searched relevant sources. Findings verified healthcare professionals.We identified four 15 features fog: perceived variability, subjective cognitive dysfunction, participation limitations, changes activities. We developed model illustrating overlapping categories contributors pain: neuroanatomical neurophysiological, mental health/emotional, environmental/lifestyle.The results conclude inconsistency regarding 20 is obstructing clear understanding phenomenon therefore may impeding receiving optimal care.Introduction: Environ % à 40 des personnes souffrant de douleur chronique en tant que trouble primaire ressentent un brouillard cérébral. Des recherches antérieures ont étudié l’étiologie du « cérébral » dans affections lesquelles la se présente comme une caractéristique clé (par exemple, fibromyalgie). Cependant, elle reste sous-étudiée le contexte musculo-squelettiques chronique. Conformément aux lignes directrices actuelles matière d’examen portée, nous avons obtenu les commentaires parties prenantes provenant patients professionnels santé (PS) pour définir ce phénomène. Les objectifs spécifiques cet examen étaient déterminer facteurs contribuant au cérébral, corrélats fonctionnels évaluations utilisées mesurer, établir définition qui peut être utilisée par chercheurs faire progresser recherche soins.Méthodes: Un portée été mené utilisant recommandations méthodologie examens l’Institut al. effectuées PsycINFO réertorier sources pertinentes. résultats vérifiés auprès santé.Résultats: Nous recensé quatre caractéristiques clés : variabilité perçue, dysfonctionnement cognitif subjectif, limites changements activités fonctionnelles. élaboré modèle illustrant catégories contributeurs système musculo-squelettique Douleur chevauchent neuroanatomique neurophysiologique, mentale/émotionnelle, environnement/mode vie.Conclusion: concluent l’incohérence concerne ne permet pas d’avoir compréhension claire phénomène donc empêcher recevoir soins optimaux.

---

Neurocognitive Function in Adult Cancer Patients

Neurologic Clinics, Год журнала: 2018, Номер 36(3), С. 653 - 674

Опубликована: Июль 30, 2018

Язык: Английский

---

Processing efficiency in pediatric cancer survivors: A review and operationalization for outcomes research and clinical utility

Brain and Behavior, Год журнала: 2022, Номер 12(12)

Опубликована: Ноя. 3, 2022

Childhood cancer and cancer-related treatments disrupt brain development maturation, placing survivors at risk for cognitive late effects. Given that assessment tools vary widely across researchers clinicians, it has been daunting to identify distinct patterns in outcomes diverse types implement systematic neurocognitive screening tools. This review aims operationalize processing efficiency skill impairment-or inefficient neural as measured by working memory speed abilities-as a worthwhile avenue continued study within the context of childhood cancer.A comprehensive literature was conducted examine existing research on effects biopsychosocial factors order conceptualize trends survivors.While frequently reported pattern neurobiological (white matter) (working speed) disruption is consistent with impairment, these weaknesses have not yet fully operationalized this population. We offer theoretical model highlights impacts host biological environmental underlying substrates precede may even predict long-term functional abilities following treatment.The unified construct be useful assessing communicating skills both clinical practice. Deficits serve possible indicator due unique relationship between treatment. Continued along lines crucial advancing improving quality life survivors.

Язык: Английский

---