Captopril attenuates oxidative stress and neuroinflammation implicated in cisplatin-induced cognitive deficits in rats
Psychopharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
Язык: Английский
Low‐Intensity Focused Ultrasound Ameliorates Cisplatin‐Induced Cognitive Impairment by Attenuating Hippocampal Neuroinflammation and Enhancing Synaptic Plasticity in Rats
iRadiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
ABSTRACT
Background
Platinum
can
cause
chemotherapy‐related
cognitive
impairment.
Low‐intensity
focused
ultrasound
(LIFUS)
is
a
promising
noninvasive
physical
stimulation
method
with
unique
advantage
in
neurological
rehabilitation.
We
aimed
to
investigate
whether
LIFUS
alleviate
cisplatin‐induced
impairment
rats
and
explore
the
related
neuropathological
mechanisms.
Methods
After
confirming
target
position
for
treatment
18
rats,
64
were
randomly
divided
into
four
groups:
control,
model,
sham,
groups.
Before
after
treatment,
detailed
biological
behavioral
assessments
magnetic
resonance
imaging
performed.
Finally,
euthanized,
relevant
histopathological
molecular
experiments
conducted
analyzed.
Results
In
Morris
water
maze,
model
group
showed
fewer
platform
crossings
(1.25
±
0.93
vs.
5.69
1.58),
longer
escape
latency
(41.65
36.55
s
6.38
2.11
s),
lower
novel
object
recognition
index
(29.77
11.83
83.69
5.67)
than
control
group.
improved
these
metrics,
more
(3.13
0.34),
higher
(65.58
8.71),
shorter
(6.45
2.27
s).
Longitudinal
analysis
of
further
confirmed
improvements.
Neuroimaging
revealed
significant
differences
diffusion
tensor
metrics
specific
brain
regions
pre‐
post‐LIFUS.
Moreover,
neuropathology
dendritic
spine
density,
less
myelin
loss,
apoptotic
cells,
synapses,
mitochondrial
autophagy
treatment.
The
neuroimaging
indicators
correlated
improvements,
highlighting
potential
alleviating
(as
demonstrated
through
analysis).
Our
investigation
mechanisms
distinct
protein
expression
patterns
hippocampus
its
subregions.
group,
glial
fibrillary
acidic
(GFAP)
ionized
calcium‐binding
adaptor
molecule
1
(IBA1)
levels
elevated
across
hippocampus,
whereas
neuronal
nuclei
(NeuN)
was
reduced.
Subregional
GFAP
IBA1
NeuN,
especially
dentate
gyrus
subregion.
positive
cell
areas
larger
cornu
ammonis
(CA)1,
CA2,
CA3,
regions.
CA2
among
groups
observed
GFAP‐positive
counts
areas,
there
variations
NeuN
expression.
Conclusions
results
suggest
that
reverse
impairments.
findings
consistent
histological
basis
supports
research
clinical
applications
LIFUS.
Furthermore,
appeared
enhance
plasticity
synapses
rat
reduce
hippocampal
inflammation.
These
highlight
as
an
effective,
therapeutic
strategy
monitoring
tool
chemotherapy‐induced
deficits.
Язык: Английский
Potential of Natural Phenolic Compounds against Doxorubicin-Induced Chemobrain: Biological and Molecular Mechanisms Involved
Antioxidants,
Год журнала:
2024,
Номер
13(4), С. 486 - 486
Опубликована: Апрель 18, 2024
Chemotherapy-induced
cognitive
impairment
or
"chemobrain"
is
a
prevalent
long-term
complication
of
chemotherapy
and
one
the
more
devastating.
Most
studies
performed
so
far
to
identify
dysfunctions
induced
by
antineoplastic
chemotherapies
have
been
focused
on
treatment
with
anthracyclines,
frequently
administered
breast
cancer
patients,
population
that,
after
treatment,
shows
high
possibility
long
survival
and,
consequently,
chemobrain
development.
In
last
few
years,
different
possible
strategies
explored
prevent
reduce
anthracycline
doxorubicin
(DOX),
known
promote
oxidative
stress
inflammation,
which
strongly
implicated
in
development
this
brain
dysfunction.
Here,
we
critically
analyzed
results
preclinical
from
years
that
evaluated
potential
phenolic
compounds
(PheCs),
large
class
natural
products
able
exert
powerful
antioxidant
anti-inflammatory
activities,
inhibiting
DOX-induced
chemobrain.
Several
PheCs
belonging
classes
shown
be
revert
morphological
damages
deficits
associated
learning,
memory,
exploratory
behavior.
We
biological
molecular
mechanisms
suggested
future
perspectives
research
area.
Язык: Английский
Distinct Morning and Evening Fatigue Profiles in Patients With Gynecologic Cancers Receiving Chemotherapy
Oncology nursing forum,
Год журнала:
2025,
Номер
52(2), С. E35 - E57
Опубликована: Фев. 18, 2025
To
identify
distinct
morning
and
evening
fatigue
profiles
in
patients
with
gynecologic
cancers
evaluate
for
differences
demographic
clinical
characteristics,
common
symptoms,
quality-of-life
outcomes.
Outpatients
(N
=
233)
were
recruited
before
their
second
or
third
cycles
of
chemotherapy
at
four
cancer
centers
San
Francisco
Bay
New
York.
The
Lee
Fatigue
Scale
was
completed
six
times
over
two
the
evening.
Latent
profile
analysis
used
to
profiles.
Four
classes
identified.
Common
risk
factors
included
younger
age,
higher
body
mass
index,
lower
functional
status,
comorbidity
burden.
Patients
worst
reported
levels
anxiety,
depression,
sleep
disturbance;
energy
cognitive
function;
poorer
quality
life.
Clinicians
can
use
this
information
higher-risk
develop
individualized
interventions
fatigue.
Язык: Английский
The chemotherapy agent doxorubicin induces CNS expression of Ascl1, a regulator of adult neurogenesis and differentiation
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 21, 2025
Cancer-related
cognitive
impairment
(CRCI)
is
a
common
side
effect
of
cancer
and
its
treatments.
Cancer
chemotherapy
has
been
associated
with
hippocampal
dysfunction
memory
impairment.
We
investigated
the
effects
one
agent,
doxorubicin,
on
transcription
factor
Ascl1
proliferation
stem
cells
in
brain.
used
an
inducible
mouse
model
designed
to
express
TdTomato
Ascl1-lineage
cells.
Five
six-month-old
Ascl1-CreERT2:ROSA
mice
were
treated
peripherally
single
dose
either
doxorubicin
(10
mg/kg)
or
DMSO
control
(n
=
9
per
group,
n
4–5
sex).
analyzed
brains
that
had
exposed
for
2
weeks
induced
expression
after
first
week.
immunostaining
neurogenesis
stage
specific
markers
evaluate
neuronal
differentiation
dentate
gyrus
hippocampus.
Overall,
significantly
increased
by
81%
at
this
time
point.
As
measured
double
stains
Sox2,
GFAP,
NeuroD1,
doxorubicin-treated
experienced
increase
Ascl1-mediated
neural
compared
control.
A
similar
significant
number
Ascl1-expressing
(by
146%)
treatment
was
observed
gray
matter
cerebral
cortex.
Thus,
rather
than
leading
loss
developing
neurons,
we
found
their
appearance
progression,
suggesting
losses
from
chemotherapies
may
require
greater
more
sustained
damage.
Язык: Английский
Meta-analyses of executive function deficits in chemotherapy-treated rodent models
Neuroscience & Biobehavioral Reviews,
Год журнала:
2025,
Номер
unknown, С. 106131 - 106131
Опубликована: Апрель 1, 2025
People
diagnosed
with
cancer
who
undergo
chemotherapy
commonly
encounter
cognitive
changes,
particularly
in
executive
functions
(EFs).
EFs
support
goal-directed
behaviours,
EF
deficits
implicated
various
neurocognitive
impairments.
We
conducted
five
meta-analyses
of
the
rodent
models
to
investigate
impact
across
domains.
A
systematic
search
PubMed,
Web
Science,
Scopus,
and
PsycINFO
yielded
56
eligible
papers.
Our
findings
supported
clinical
literature
suggesting
selective
on
different
Specifically,
chemotherapy-treated
animals
performed
significantly
more
poorly
than
controls
tasks
assessing
working
memory,
behavioural
flexibility,
problem-solving,
no
significant
group
differences
inhibition
or
attention.
Subgroup
analyses
revealed
that
alkylating
agents,
antitumor
antibiotics,
combination
therapies
were
strongly
associated
memory
deficits,
whereas
mitotic
inhibitors
not.
Rodent
species,
strain,
age,
sex,
number
treatments,
time
assessment
since
end
treatment
did
not
moderate
drug
effect
any
assessed
To
increase
generalisability
translational
validity
results,
overall
reporting
quality
animal
studies
needs
be
improved
details
randomisation,
blinding,
sample
sizes,
criteria
for
exclusions.
Язык: Английский
Plant-Derived Natural Compounds as an Emerging Antiviral in Combating COVID-19
Indian Journal of Microbiology,
Год журнала:
2023,
Номер
63(4), С. 429 - 446
Опубликована: Окт. 31, 2023
Язык: Английский
The NF-κB Pathway: Key Players in neurocognitive functions and related disorders
Danfeng Yang,
Junwei Su,
Yeru Chen
и другие.
European Journal of Pharmacology,
Год журнала:
2024,
Номер
984, С. 177038 - 177038
Опубликована: Окт. 5, 2024
Язык: Английский
Chemo brain: myth or clinical reality? Literature review and clinical case
Neurology Bulletin,
Год журнала:
2024,
Номер
LVI(4), С. 426 - 438
Опубликована: Дек. 19, 2024
The
review
presents
a
psychopathological
phenomenon
new
for
the
Russian
psychiatry.
It
combines
various
cognitive
and
entities
(hallucinations,
delusions,
consciousness
disorders)
occurring
in
cancer
patients
as
result
of
chemotherapy.
In
foreign
literature,
such
are
generalized
under
common
terms
chemo
brain,
fog,
post-chemotherapy
impairment
(PCCI).
Chemo
Brain
is
symptom
complex
developing
after
treatment
with
groups
chemotherapeutic
drugs
caused
by
certain
functional
structural
brain
changes.
This
article
collates
data
on
etiology,
pathogenesis,
clinical
features
interventions
case
disorders
generally
known
Brain.
addition,
it
discusses
most
often
inducing
Fog
(Cisplatin,
Doxorubicin,
Methotrexate,
5-fluorouracil),
severe
confusion
episode.
A
74-year-old
female
patient
undergoing
chemotherapy
sigmoid
colon
carcinoma
metastases
experienced
sharp
deterioration
memory,
self-care,
mobility
routine
round.
had
been
treated
cocktail
3
years
several
surgeries.
With
acute
memory
impairment,
she
consulted
internal
medicine
department.
doctors
were
puzzled
her
symptoms.
Having
received
advice
medical
specialists
corresponding
treatment,
showed
improvement
both
motor
functions.
emphasizes
need
further
research
drug
treatment.
Язык: Английский