Translational Lung Cancer Research,
Год журнала:
2023,
Номер
12(7), С. 1391 - 1413
Опубликована: Июль 1, 2023
Individuals
with
lung
cancer
(LC)
face
a
variety
of
symptoms
that
significantly
impact
their
lives.
We
use
extensive
patient
input
to
determine
the
relative
importance
and
prevalence
these
identify
which
demographic
features
are
associated
higher
level
disease
burden.We
performed
semi-structured
qualitative
interviews
participants
LC
potentially
important
symptoms.
then
conducted
cross-sectional
study,
in
rated
162
individual
covering
14
symptomatic
themes.
Participant
responses
were
analyzed
by
age,
sex,
disability
status,
duration,
stage,
type
treatment
received,
smoking
history,
among
other
categories.Our
study
had
139
LC.
The
most
prevalent
themes
reported
this
population
fatigue
(85.5%),
impaired
sleep
daytime
sleepiness
(73.5%),
emotional
issues
(73.0%).
greatest
average
(on
scale
0
4,
4
being
impactful)
social
role
dissatisfaction
(1.67),
inability
do
activities
(1.64),
(1.60).
Disability
status
strongest
association
theme
prevalence.
stage
(stage
IV),
receipt
therapy,
experience
also
frequency
themes.Individuals
diverse
disease-specific
affect
daily
Patient
insight
on
is
invaluable
advance
meaningful
therapeutic
interventions.
Brain
tumor
vasculature
can
be
significantly
compromised
and
leakier
than
that
of
normal
brain
blood
vessels.
Little
is
known
if
there
are
vascular
permeability
alterations
in
the
adjacent
to
(BAT).
Changes
BAT
may
also
lead
increased
drug
permeation
BAT,
which
exert
toxicity
on
cells
central
nervous
system.
Herein,
we
studied
changes
using
quantitative
fluorescent
microscopy
autoradiography,
while
effect
chemotherapy
within
region
was
determined
by
staining
for
activated
astrocytes.
Human
metastatic
breast
cancer
(MDA-MB-231Br)
were
injected
into
left
ventricle
female
NuNu
mice.
Metastases
allowed
grow
28
days,
after
animals
tracers
Texas
Red
(625
Da)
or
dextran
(3
kDa)
a
chemotherapeutic
agent
14C-paclitaxel.
The
accumulation
14C-paclitaxel
autoradiography
respectively.
mean
texas
1.0
2.5-fold
when
compared
brain,
whereas,
demonstrated
increase
ranging
from
1.8-fold
brain.
Kin
values
both
found
4.32
±
0.2
×
105
mL/s/g
1.6
1.4
respectively
higher
We
significant
14C-Paclitaxel
observed
treated
with
(paclitaxel
(10
mg/kg),
erubilin
(1.5
mg/kg)
docetaxel
mg/kg))
showed
astrocytes
BAT.
Our
data
This
elevated
levels
chemotherapy.
Psychiatria Danubina,
Год журнала:
2023,
Номер
35(1), С. 73 - 79
Опубликована: Апрель 13, 2023
Background:
This
research
was
conducted
to
objectively
evaluate
the
level
of
brain
fog
that
may
develop
due
many
reasons.Subjects
and
methods:
a
methodological
study.This
study
in
Turkey.Content
validity
ratio,
EFA,
CFA,
Kaiser-Meyer-Olkin
analysis
Bartlett's
test
sphericity,
Item
analysis,
Cronbach's
alpha
coefficient,
Spearman-Brown,
Guttman
Analysis
test-retest
correlations
validity-reliability
were
performed.The
statistical
meaningfulness
all
tests
determined
as
p<0.05.Results:
As
result
context
validity,
factor
item
30
scale
with
3
subscale
obtained.The
variance
amount
explained
by
on
very
good
(77.43%).The
fact
Cronbach
alpha,
Spearman-Brown
internal
consistency
coefficients
its
are
above
0.70.When
retest
reliability
examined,
found
present
consistent
results
different
applications
be
reliable
regard
constancy
coefficient.
Conclusion:The
Brain
Fog
Scale
consists
items
subscales.It
is
valid
instrument.
Translational Lung Cancer Research,
Год журнала:
2023,
Номер
12(7), С. 1391 - 1413
Опубликована: Июль 1, 2023
Individuals
with
lung
cancer
(LC)
face
a
variety
of
symptoms
that
significantly
impact
their
lives.
We
use
extensive
patient
input
to
determine
the
relative
importance
and
prevalence
these
identify
which
demographic
features
are
associated
higher
level
disease
burden.We
performed
semi-structured
qualitative
interviews
participants
LC
potentially
important
symptoms.
then
conducted
cross-sectional
study,
in
rated
162
individual
covering
14
symptomatic
themes.
Participant
responses
were
analyzed
by
age,
sex,
disability
status,
duration,
stage,
type
treatment
received,
smoking
history,
among
other
categories.Our
study
had
139
LC.
The
most
prevalent
themes
reported
this
population
fatigue
(85.5%),
impaired
sleep
daytime
sleepiness
(73.5%),
emotional
issues
(73.0%).
greatest
average
(on
scale
0
4,
4
being
impactful)
social
role
dissatisfaction
(1.67),
inability
do
activities
(1.64),
(1.60).
Disability
status
strongest
association
theme
prevalence.
stage
(stage
IV),
receipt
therapy,
experience
also
frequency
themes.Individuals
diverse
disease-specific
affect
daily
Patient
insight
on
is
invaluable
advance
meaningful
therapeutic
interventions.
