Clinical Epigenetics,
Год журнала:
2023,
Номер
15(1)
Опубликована: Апрель 26, 2023
Disadvantaged
socioeconomic
position
(SEP),
including
lower
educational
attainment
and
household
income,
may
influence
cancer
risk
outcomes.
We
hypothesized
that
DNA
methylation
could
function
as
an
intermediary
epigenetic
mechanism
internalizes
reflects
the
biological
impact
of
SEP.
Based
on
tumor
data
from
Illumina
450
K
array
694
breast
patients
in
Women's
Circle
Health
Study,
we
conducted
epigenome-wide
analysis
relation
to
income.
Functional
identified
CpG
sites
was
explored
silico
using
publicly
available
databases.
25
associated
with
income
at
array-wide
significance
level,
but
none
attainment.
Two
top
sites,
cg00452016
cg01667837,
were
promoter
regions
NNT
GPR37,
respectively,
multiple
regulatory
features
each
region.
is
involved
β-adrenergic
stress
signaling
inflammatory
responses,
whereas
GPR37
neurological
immune
responses.
For
both
loci,
gene
expression
inversely
correlated
levels
methylation.
The
associations
consistent
between
Black
White
women
did
not
differ
by
estrogen
receptor
(ER)
status.
In
a
large
patient
population,
discovered
evidence
significant
methylome,
genes
response
pathways.
Our
findings
support
effects
status
tissues,
which
might
be
relevant
development
progression.
Current Environmental Health Reports,
Год журнала:
2022,
Номер
9(3), С. 490 - 501
Опубликована: Апрель 29, 2022
Abstract
Purpose
of
Review
The
developmental
origins
health
and
disease
(DOHaD)
hypothesis
posits
that
the
perinatal
environment
can
impact
fetal
later
life
health.
placenta
is
uniquely
situated
to
assess
prenatal
exposures
in
context
DOHaD
because
it
an
essential
ephemeral
organ
manages
transport
oxygen,
nutrients,
waste,
endocrine
signals
between
mother
fetus.
purpose
this
review
summarize
recent
studies
evaluated
human
placentas
using
epigenomics,
including
DNA
methylation
transcriptomic
mRNA,
lncRNA,
microRNAs.
Recent
Findings
Between
2016
2021,
28
articles
associations
placental
epigenomics
across
broad
exposure
categories
maternal
smoking,
psychosocial
stressors,
chemicals,
air
pollution,
metals.
Sixteen
these
connected
outcome
such
as
birth
weight,
growth,
or
infant
neurobehavior
through
mediation
analysis,
identification
shared
outcome,
network
analysis.
These
aspects
childhood
serve
a
foundation
for
future
aim
use
epigenetics
understand
relationships
complications
(such
preterm
growth
restriction)
Summary
Placental
RNA
expression
have
been
linked
numerous
exposures,
PM2.5
metals,
well
outcomes,
weight.
provides
unique
opportunity
expand
premise,
particularly
if
research
applies
novel
methodologies
multi-omics
sequencing
non-coding
RNAs,
mixtures
assessment
outcomes
beyond
early
childhood.
Annual Review of Public Health,
Год журнала:
2022,
Номер
43(1), С. 235 - 254
Опубликована: Апрель 5, 2022
Longstanding
racial/ethnic
inequalities
in
morbidity
and
mortality
persist
the
United
States.
Although
determinants
of
health
are
complex,
social
structural
factors
produced
by
inequitable
racialized
systems
recognized
as
contributing
sources.
Social
epigenetics
is
an
emerging
area
research
that
aims
to
uncover
biological
pathways
through
which
experiences
affect
outcomes.
A
growing
body
literature
links
adverse
exposures
epigenetic
mechanisms,
namely
DNA
methylation,
offering
a
plausible
pathway
may
arise.
This
review
provides
overview
highlights
existing
linking
exposures—i.e.,
psychosocial
stressors,
racism,
discrimination,
socioeconomic
position,
neighborhood
environment—to
methylation
humans.
We
conclude
with
discussion
mechanistic
link
provide
suggestions
for
future
on
inequalities.
Frontiers in Psychiatry,
Год журнала:
2020,
Номер
11
Опубликована: Март 20, 2020
Susceptibility
and
resilience
to
mental
disorders
result
from
a
complex
choreography
of
gene-environment
interactions
with
epigenetics
at
the
intersection
external
psychological
stressors
internal
biological
systems.
Increasing
awareness
growing
disease
burden
influenced
by
daily
life
stress
("daily
hassles"),
work-related
stress,
low
socioeconomic
status
(SES)
has
resulted
in
novel
interest
into
their
underlying
molecular
signatures.
This
review
offers
brief
outline
psychiatric
comprehensive
overview
recent
findings
exploring
relationship
various
occupational
DNA
methylation
epigenome-wide
association
studies
(EWAS)
candidate
gene
including
serotonin
transporter
(SLC6A4;
5-HTTLPR),
melatonin
receptor
1A
(MTNR1A),
brain-derived
neurotrophic
factor
(BDNF),
tyrosine
hydroxylase
(TH),
protein
family
methyltransferases
(DNMTs).
Conceptual
methodological
challenges
epigenetic
investigations
special
focus
on
are
highlighted
discussed.
The
integrated
pathophysiological
framework
featuring
plasticity
factors
as
possible
central
detrimental
component
targetable
workplace
interventions.
Finally,
potential
dynamic
biomarkers
treatment
response
pharmacotherapy
or
psychotherapy
is
expanded
upon.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Фев. 4, 2022
As
the
master
regulator
in
utero,
placenta
is
core
to
Developmental
Origins
of
Health
and
Disease
(DOHaD)
hypothesis
but
historically
understudied.
To
identify
placental
gene-trait
associations
(GTAs)
across
life
course,
we
perform
distal
mediator-enriched
transcriptome-wide
association
studies
(TWAS)
for
40
traits,
integrating
multi-omics
from
Extremely
Low
Gestational
Age
Newborn
Study.
At
[Formula:
see
text],
detect
248
GTAs,
mostly
neonatal
metabolic
176
genes,
enriched
cell
growth
immunological
pathways.
In
aggregate,
genetic
effects
mediated
by
expression
significantly
explain
4
early-life
traits
no
later-in-life
traits.
89
GTAs
show
significant
mediation
through
variants,
identifying
hypotheses
regulation
GTAs.
Investigation
one
human
placenta-derived
choriocarcinoma
cells
reveal
that
knockdown
mediator
gene
EPS15
upregulates
predicted
targets
SPATA13
FAM214A,
both
associated
with
waist-hip
ratio
TWAS,
multiple
genes
involved
These
results
suggest
profound
health
impacts
genomic
developmental
programming
course.
Dialogues in Clinical Neuroscience,
Год журнала:
2019,
Номер
21(4), С. 369 - 378
Опубликована: Дек. 31, 2019
Early
life
adversity
is
associated
with
long-term
effects
on
physical
and
mental
health
later
in
life,
but
the
mechanisms
are
yet
unclear.
Epigenetic
program
cell-type-specific
gene
expression
during
development,
enabling
one
genome
to
be
programmed
many
ways,
resulting
diverse
stable
profiles
of
different
cells
organs
body.
DNA
methylation,
an
enzymatic
covalent
modification
DNA,
has
been
principal
epigenetic
investigated.
Emerging
evidence
consistent
idea
that
processes
involved
embedding
impact
early-life
experience
mediating
between
social
environments
behavioral
phenotypes.
Whereas
there
supporting
this
hypothesis
animal
studies,
human
studies
have
less
conclusive.
A
major
problem
fact
brain
inaccessible
humans
relevance
methylation
peripheral
tissues
phenotypes
questioned.
In
addition,
usually
confounded
genetic
environmental
heterogeneity
it
very
difficult
derive
causality.
The
mediate
life-long
perinatal
attractive
potential
implications
for
early
detection,
prevention,
intervention
disorders
will
discussed.
.Si
bien
la
adversidad
en
los
inicios
de
vida
se
asocia
con
efectos
a
largo
plazo
salud
física
y
mental,
mecanismos
aún
no
están
claros.
Los
epigenéticos
programan
durante
el
desarrollo
expresión
génica
específica
un
tipo
celular,
lo
que
permite
genoma
programe
muchas
maneras,
dando
así
como
resultado
diversos
perfiles
estables
diferentes
células
órganos
del
cuerpo.
Uno
principales
investigados
ha
sido
metilación
ADN,
una
modificación
enzimática
covalente
ADN.
La
reciente
evidencia
es
consistente
procesos
involucrados
incorporación
impacto
experiencia
mediación
entre
ambientes
sociales
fenotipos
conductuales
posteriores.
Aunque
respalda
esta
hipótesis
estudios
animales,
humanos
resultados
han
menos
concluyentes.
Un
problema
importante
hecho
cerebro
humano
inaccesible
para
cuestionado.la
relevancia
ADN
tejidos
periféricos
conductuales.
Además,
suelen
confundirse
heterogeneidad
genética
ambiental,
muy
difícil
derivar
causalidad.
median
toda
tiene
interesantes
implicaciones
potenciales
detección
temprana,
prevención
intervención
trastornos
discutirán.Les
épreuves
précoces
vie
sont
associées
à
des
effets
long
terme
sur
santé
mentale
et
physique
mais
les
mécanismes
n’en
toujours
pas
compris.
Des
épigénétiques
programment
l’expression
génique
spécifique
d’un
type
cellulaire
au
cours
du
développement
permettant
génome
d’être
programmé
diverses
façons,
ce
qui
entraîne
divers
profils
stables
d’expression
dans
différents
organes
cellules
corps.
méthylation
l’ADN,
une
enzymatique
est
l’un
principaux
étudiés.
D’après
nouvelles
données,
processus
jouent
rôle
l’intégration
l’impact
expériences
le
médiation
l’environnement
phénotypes
tardifs
comportement.
Cette
hypothèse
soutenue
par
données
issues
d’études
animaux,
études
humains
moins
concluantes.
L’inaccessibilité
cerveau
aux
chez
l’homme
représente
problème
majeur.
Et
pertinence
l’ADN
tissus
périphériques
pour
expliquer
comportementaux
été
remise
question.
De
plus,
causalité
très
difficile
déduire
car
couramment
faussées
hétérogénéité
génétique
environnementale.
L’hypothèse
sous-tendent
stress
périnatal
potentielles
prometteuses
détection
précoce,
prévention
traitement
troubles
mentaux.
Elles
seront
discutées
ici.
Frontiers in Ecology and Evolution,
Год журнала:
2020,
Номер
8
Опубликована: Май 6, 2020
Applying
high-throughput
DNA
sequencing
technologies
to
the
ancient
molecules
preserved
in
subfossil
material
can
provide
genetic
information
from
past
individuals,
populations
and
communities
at
genomic
scale.
The
combination
of
dedicated
statistical
techniques
specific
molecular
tools
aimed
reducing
impact
post-mortem
damage
also
help
recover
epigenetic
data
individuals.
However,
capacity
different
sequence
aligners
identify
ultrashort
deaminated
templates,
their
on
characterization
methylomes,
remain
overlooked.
In
this
study,
we
use
both
simulated
real
benchmark
performance
read
alignment
most
commonly
used
research.
We
a
strategy
making
Bowtie2
aligner
that
substantially
reduce
computational
times
but
shows
increased
sensitivity
relative
previous
recommendations
based
BWA
aligner.
This
significantly
improves
genome
coverage
especially
when
templates
are
shorter
than
90bp,
as
is
typically
case
for
DNA.
It
impacts
methylation
estimates
it
maximizes
improvement
within
CpG
dinucleotide
contexts,
which
hold
vast
majority
marks
mammals.
Our
work
contributes
improve
accuracy
maps
maximize
amount
recoverable
archaeological
material.
As
complexity
libraries
generally
limited,
mapping
recommended
here
essential
limit
costs
sample
destruction.
