Allostatic Load and Its Impact on Health: A Systematic Review

Psychotherapy and Psychosomatics, Год журнала: 2020, Номер 90(1), С. 11 - 27

Опубликована: Авг. 14, 2020

Allostatic load refers to the cumulative burden of chronic stress and life events. It involves interaction different physiological systems at varying degrees activity. When environmental challenges exceed individual ability cope, then allostatic overload ensues. is identified by use biomarkers clinical criteria.To summarize current knowledge on its implications based a systematic review literature.PubMed, PsycINFO, Web Science, Cochrane Library were searched from inception December 2019. A manual search literature was also performed, reference lists retrieved articles examined.We considered only studies in which or adequately described assessed either non-clinical adult populations.A total 267 original investigations included. They encompassed general population studies, as well consequences load/overload both physical mental health across variety settings.The findings indicate that are associated with poorer outcomes. Assessment provides support understanding psychosocial determinants lifestyle medicine. An integrated approach includes biological markers clinimetric criteria recommended.

Язык: Английский

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Social Safety Theory: Conceptual foundation, underlying mechanisms, and future directions

Health Psychology Review, Год журнала: 2023, Номер 17(1), С. 5 - 59

Опубликована: Янв. 2, 2023

Classic theories of stress and health are largely based on assumptions regarding how different psychosocial stressors influence biological processes that, in turn, affect human behavior. Although theoretically rich, this work has yielded little consensus led to numerous conceptual, measurement, reproducibility issues. Social Safety Theory aims address these issues by using the primary goal regulatory logic brain immune system as basis for specifying social-environmental situations which systems should respond most strongly maximize reproductive success survival. This analysis gave rise integrated, multi-level formulation described herein, transforms thinking about biology provides a biologically based, evolutionary account why experiences social safety threat related health, well-being, aging, longevity. In doing so, theory advances testable framework investigating biopsychosocial roots disparities well health-relevant crystalize over time perceptions environment interact with childhood microbial environment, birth cohort, culture, air pollution, genetics, sleep, diet, personality, self-harm health. The also highlights several interventions reducing promoting resilience.

Язык: Английский

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Epigenetics of prenatal stress in humans: the current research landscape

Clinical Epigenetics, Год журнала: 2024, Номер 16(1)

Опубликована: Фев. 2, 2024

Abstract Fetal exposure to prenatal stress can have significant consequences on short- and long-term health. Epigenetic mechanisms, especially DNA methylation (DNAm), are a possible process how these adverse environmental events could be biologically embedded. We evaluated candidate gene as well epigenome-wide association studies associating DNAm changes in peripheral tissues; however, most of findings lack robust replication. Prenatal stress-associated epigenetic also been linked child health including internalizing problems, neurobehavioral outcomes reactivity. Future should focus refined measurement definition its timing, ideally incorporating genomic longitudinal information. This will provide further opportunities enhance our understanding the biological embedding exposure.

Язык: Английский

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The significance of DNA methylation of the NR3C1 gene encoding the glucocorticoid receptor for developing resilience in individuals exposed to early life stress

Nordic Journal of Psychiatry, Год журнала: 2025, Номер unknown, С. 1 - 14

Опубликована: Янв. 7, 2025

Purpose To analyze and interpret why some individuals are resilient to ELS while others susceptible, resulting in psychiatric outcome later life, with a focus on the role of DNAm NR3C1 gene as mediating mechanism between risk outcomes. We hypothesized that high level mental resilience ELS, expressed lower incidence outcomes, was associated attenuated levels.

Язык: Английский

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Canada’s Colonial Genocide of Indigenous Peoples: A Review of the Psychosocial and Neurobiological Processes Linking Trauma and Intergenerational Outcomes

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(11), С. 6455 - 6455

Опубликована: Май 26, 2022

The policies and actions that were enacted to colonize Indigenous Peoples in Canada have been described as constituting cultural genocide. When one considers the long-term consequences from perspective of social environmental determinants health framework, impacts such on physical mental go well beyond loss. This paper addresses key historical current Canadian federal relation well-being Peoples. Far a mere lesson history, connections between colonialist present-day outcomes are evaluated terms transgenerational intergenerational transmission processes, including psychosocial, developmental, environmental, neurobiological mechanisms trauma responses. In addition, while created adverse living conditions for Peoples, resilience perseverance many aspects culture may be maintained through processes.

Язык: Английский

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Epigenetic (re)programming of gene expression changes of CB1R and FAAH in the medial prefrontal cortex in response to early life and adolescence stress exposure

Frontiers in Cellular Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Фев. 22, 2023

Environmental factors, including stress, that are experienced during early life (ELS) or adolescence potential risk factors for the development of behavioral and mental disorders later in life. The endocannabinoid system plays a major role regulation stress responses emotional behavior, thereby acting as mediator vulnerability resilience. Among critical which determine magnitude direction long-term consequences exposure is age, i.e., maturity brain circuits exposure. Thus, present study addressed hypotheses ELS adolescent differentially affect expression regulatory elements system, cannabinoid receptor 1 (CB1R) fatty acid amide hydrolase (FAAH) medial prefrontal cortex (mPFC) adult female rats. We also tested hypothesis proposed gene changes epigenetically modulated via altered DNA-methylation. specific aims were to investigate if (i) single stressors induce CB1R FAAH (ii) influences effect on expression, (iii) paralleled by DNA methylation. following experimental groups investigated: (1) non-stressed controls (CON), (2) (ELS), (3) (forced swimming; FS), (4) + FS found an up-regulation both single-stressor reduction back control levels group. An was only data indicate ELS, very immature stage development, exerts buffering programming induced stress. detected accompanied methylation patterns promoter region these genes, specifically, negative correlation mean with found. Our results induces “(re)programming” effect, characterized CpG-site within regions two genes influence response at adolescence.

Язык: Английский

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What’s it got to do with the Brain? Mobilising and Doing Clinical Relevance in Epigenetic Psychiatric Research

Minerva, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Язык: Английский

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Resilience: Safety in the Aftermath of Traumatic Stressor Experiences

Frontiers in Behavioral Neuroscience, Год журнала: 2020, Номер 14

Опубликована: Дек. 21, 2020

The relationship between adverse experiences and the emergence of pathology has often focused on characteristics stressor or individual (stressor appraisals, coping strategies). These features are thought to influence multiple biological processes that favor development mental physical illnesses. Less attention aftermath traumatic experiences, importance safety reassurance is necessary for longer-term well-being. In some cases (e.g., post-traumatic stress disorder) this may be reflected by a failure fear extinction, whereas in other instances historical trauma), uncertainty about future might foster continued anxiety. essence, question becomes one how individuals attain feelings when it fully understood world not necessarily safe place, uncertainties abound, agency illusory. We consider acquire resilience chronic stressors. respect, we review stressors trigger particular behavioral responses, as well factors undermine their efficacy. To end, explore dynamics social response specific traumatic, chronic, uncontrollable contexts (intimate partner abuse; refugee migration; collective trauma). point comprise neurobiological changes, such those related various stressor-provoked hormones, neurotrophins, inflammatory immune, microbial, epigenetic processes. responses influence, influenced by, come through relationships with others, spiritual place-based connections.

Язык: Английский

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Sexual differentiation of the human hypothalamus: Relationship to gender identity and sexual orientation

Handbook of clinical neurology, Год журнала: 2021, Номер unknown, С. 427 - 443

Опубликована: Янв. 1, 2021

Язык: Английский

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Psychic Life-Biological Molecule Bidirectional Relationship: Pathways, Mechanisms, and Consequences for Medical and Psychological Sciences—A Narrative Review

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(7), С. 3932 - 3932

Опубликована: Апрель 1, 2022

Today, it is possible to investigate the biological paths and mechanisms that link mental life life. Emotions, feelings, desires, cognitions influence systems. In recent decades, psychoneuroendocrinoimmunology research has highlighted routes linking psyche-brain-immune Recently, epigenetics shown molecular by which stress states modulate information contained in genome. This shapes a new paradigm considering human being as whole, integrating biology psychology. will allow us progress towards personalized precision medicine, deeply changing medical psychological sciences clinical practice. this paper, we recognize leading on both bidirectional relations between psyche-brain-immunity consequences of states.

Язык: Английский

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