Colloids and Interfaces,
Год журнала:
2022,
Номер
6(2), С. 35 - 35
Опубликована: Май 29, 2022
This
research
is
focused
on
the
adsorption
modification
of
detonation
nanodiamond
surfaces
with
antibiotics
for
their
further
use
as
smart
materials
cardiovascular
surgery
purposes,
namely
bioprostheses
modifiers.
Tritium-labeled
amikacin
and
levofloxacin
were
used
tracers
process
control.
We
found
that
nanodiamonds
form
complexes
via
physical
adsorption,
while
in
case
amikacin,
electrostatic
attraction
contributes
to
formation
more
stable
complexes,
even
presence
electrolytes
desorbing
agents
(models
biological
fluids).
Antimicrobial
characterization
nanodiamond–levofloxacin
nanodiamond–amikacin
indicates
a
reduction
dose
an
antimicrobial
agent.
Therefore,
biomaterial
based
DND
basis
will
allow
one
either
avoid
or
significantly
reduce
duration
intensity
postoperative
period,
which
critically
important
from
viewpoint
development
antibiotic
resistance
pathogens.
Accounts of Chemical Research,
Год журнала:
2022,
Номер
55(24), С. 3594 - 3604
Опубликована: Ноя. 29, 2022
ConspectusInterest
in
nanodiamond
(ND)
has
been
spurred
by
its
unique
properties
such
as
high
biocompatibility,
versatile
surface
chemistry,
and
the
possibility
to
apply
it
drug
delivery
agent,
cross-linker,
or
coating
for
sensing
applications
when
luminescent
lattice
defects
NV
centers
are
present
crystal
lattice.
Currently,
used
targeted
delivery,
phototherapeutic
applications,
imaging
cellular
environments
vitro.
Furthermore,
suitably
functionalized
is
a
promising
material
tissue
engineering
applications.
However,
application
of
long
hampered
number
obstacles
challenges
met
with
commercially
available
nanodiamonds
different
origins.
A
major
issue
related
strong
agglomeration
individual
particles
resulting
covalently
linked
aggregates
larger
sizes
broad
size
distribution.
termination
typical
tends
be
rather
inhomogeneous,
containing
multitude
functional
groups.
The
retention
functionality
immobilized
moieties
bioapplications
often
not
known.
And
finally,
possesses
propensity
nonspecific
interaction,
especially
proteins
from
serum,
cell
fluids,
culture
media
incubation
cells
nanodiamond.
protein
corona
influences
access
on
diamond
leads
reduced
reproducibility
observations
physiological
limited
attribution
effects
presence
surface.
In
this
Account,
we
describe
our
efforts
address
these
using
multiple
strategies
mainly
example
detonation
(DND).
First,
homogeneous
distribution
nanoparticles
an
initial
type
atoms
groups
can
achieved
mechanochemical
methods
treatments
reagents
both
solution
gas
phases.
Reactions
liquid
typically
lead
more
uniform
results
entire
becomes
equally
accessible.
We
have
then
worked
development
covalent
linker
accommodate
grafting
needs
thus
enable
production
orthogonally
ND
particles,
which
modified
controlled
fashion.
noncovalent
immobilization
units
useful
permits
conservation
sensitive
proteins,
denature
upon
immobilization.
summary,
work
aims
gain
full
control
over
develop
toolbox
chemical
provide
tailored
plethora
biomedical
Further
research
field
functionalization
will
cover
also
transfer
already
existing
other
types
surfaces,
stoichiometrically
dynamic
self-assembly
continuing
suitable
characterization
techniques.
RSC Advances,
Год журнала:
2024,
Номер
14(6), С. 4285 - 4300
Опубликована: Янв. 1, 2024
The
deficiency
of
oxygen
in
most
solid
tumors
plays
a
profound
role
their
proliferation,
metastasis,
and
invasion
contributes
to
resistance
treatments
such
as
radiation,
chemotherapy,
photodynamic
therapy
(PDT).
A
therapeutic
approach
based
on
the
Fenton
reaction
has
received
considerable
interest
means
treating
cancer
with
ROS-based
nano
catalytic
medicine,
referred
chemodynamic
(CDT).
range
modified
treatment
strategies
are
being
explored
enhance
both
CDT
conventional
methods
therapy.
These
include
Fenton-like
reactions,
photo-enhanced
catalytic-enhanced
synergistic
therapies.
In
this
article,
we
propose
demonstrate
photochemotherapy
(PCT)
strategy
for
utilizing
near-infrared
(NIR)-induced
reactions
using
Fe-doped
nanodiamond
(FeND).
When
FeND
is
exposed
human
lung
cells
A549,
it
exhibits
outstanding
biocompatibility.
However,
when
particle-treated
NIR
laser
particle
cytotoxicity
certain
degree.
anticancer
medication
doxorubicin
(DOX)
was
adsorbed
onto
address
issue.
conjugated
DOX
could
undergo
redox
cycle
generate
excess
H2O2
inside
cells,
addition,
can
also
cause
tumor
cell
apoptosis.
Combining
chemotherapy
(via
DOX)
results
enhanced
effectiveness.
Moreover,
intrinsic
fluorescence
be
used
monitor
interaction
particles
well
localization,
thus
making
an
excellent
imaging
probe.
our
study,
found
that
serve
agent,
biomarker,
drug
carrier,
potentially
valuable
candidate
agents
contribute
further
development
more
effective
platforms
nanodiamond.
Biomedical Materials,
Год журнала:
2024,
Номер
19(3), С. 032003 - 032003
Опубликована: Апрель 4, 2024
Abstract
In
terms
of
biomedical
tools,
nanodiamonds
(ND)
are
a
more
recent
innovation.
Their
size
typically
ranges
between
4
to
100
nm.
ND
produced
via
variety
methods
and
known
for
their
physical
toughness,
durability,
chemical
stability.
Studies
have
revealed
that
surface
modifications
functionalization
significant
influence
on
the
optical
electrical
properties
nanomaterial.
Consequently,
functional
groups
NDs
applications
in
domains,
including
drug
administration,
gene
delivery,
immunotherapy
cancer
treatment,
bio-imaging
diagnose
cancer.
Additionally,
biocompatibility
is
critical
requisite
vivo
vitro
interventions.
This
review
delves
into
these
aspects
focuses
advances
modification
strategies
various
surrounding
diagnosis
treatment.
Furthermore,
prognosis
its
clinical
translation
has
also
been
discussed.
ACS Omega,
Год журнала:
2024,
Номер
9(16), С. 17808 - 17816
Опубликована: Апрель 13, 2024
To
progress
the
clean
hydrogen-gas-based
energy
economy,
there
is
a
demand
for
cost-effective,
highly
efficient
catalysts
to
facilitate
hydrogen
evolution
reaction
process
(HER).
Due
amazing
catalytic
capabilities
of
two-dimensional
materials,
extensive
research
has
been
done
on
these
structures.
However,
most
described
syntheses
take
lot
time,
are
challenging,
and
ineffective.
The
present
work
demonstrates
performance
recently
reported
nanodiamond/graphene
composite
microsphere
ND-GCSs
as
catalyst
HER.
These
spheres
were
produced
via
microwave-irradiation
approach.
A
modified
was
adopted
improve
particle
size
uniformity
yield.
prepared
showed
very
interesting
activity
HER
when
assembled
screen-printed
carbon
electrode.
ND-GCSs@SPCE
significant
shift
onset
potential
ca.
-450
mV
small
Tafel
slope
value
85
mV/decade.
electron
transfer
drastically
enhanced
with
tremendous
decrease
in
charge
resistance
265
Ω.
electrocatalyst
excellent
long-term
stability
application.
Additionally,
this
novel
structure
might
be
beneficial
diverse
applications
including
batteries,
supercapacitors,
supports,
more.
Current Pharmaceutical Biotechnology,
Год журнала:
2023,
Номер
24(13), С. 1630 - 1644
Опубликована: Март 14, 2023
The
precise
treatment
of
liver
cancer
is
receiving
much
research
attention.
Surgery,
chemoradiotherapy,
and
other
methods
remain
the
mainstream
this
treatment,
but
many
chemotherapeutic
drugs
used
to
treat
advanced
cause
adverse
reactions
have
unstable
efficiencies.
Active
ingredients
in
traditional
Chinese
medicine
(TCM)
been
examined
widely
anti-cancer
due
their
advantages
multi-pathway
targeting
rich
pharmacological
effects.
However,
these
active
components
poor
water
solubility,
bioavailability,
efficiency.
Nanomedicine
has
applied
improve
efficacy
TCM
cancer.
Nanoparticles
(NPs)
show
great
potential
context
excellent
high
controlled
agent
release
efficiency,
clear
targeting.
This
paper
reviews
application
NPs
loaded
with
cancer,
aim
facilitating
new
vector
development
improving
precision
Frontiers in Chemistry,
Год журнала:
2021,
Номер
9
Опубликована: Май 24, 2021
Detection
of
cancer
at
an
early
stage
is
one
the
principal
factors
associated
with
successful
treatment
outcome.
However,
current
diagnostic
methods
are
not
capable
making
sensitive
and
robust
diagnosis.
Nanotechnology
based
products
exhibit
unique
physical,
optical
electrical
properties
that
can
be
useful
in
These
nanotech-enabled
representatives
have
proved
to
generally
more
consistent;
as
they
selectively
accumulated
tumor
site
due
their
miniscule
size.
This
article
rotates
around
conventional
imaging
techniques,
use
carbon
nanodots
viz
Carbon
Quantum
Dots
(CQDs),
Graphene
(GQDs),
Nanodiamonds,
Fullerene,
Nanotubes
been
synthesized
recent
years,
along
discovery
a
wide
range
biomarkers
identify
stage.
Early
detection
using
nanoconstructs
anticipated
distinct
reality
coming
years.
