Extraction and Processing of Bioactive Phytoconstituents from Widely Used South African Medicinal Plants for the Preparation of Effective Traditional Herbal Medicine Products: A Narrative Review

Plants, Год журнала: 2025, Номер 14(2), С. 206 - 206

Опубликована: Янв. 13, 2025

Medicinal plants are sources of crude traditional herbal medicines that utilized to reduce the risk of, treat, or manage diseases in most indigenous communities. This is due their potent antioxidant and anti-inflammatory effects. It estimated about 80% population developing countries rely on for healthcare. signifies need medicines, which polyherbal formulations prepared by health practitioners. review examines preparatory steps extract bioactive phytoconstituents post-extraction processes increase potency extracted phytoconstituents. Achieving this will allow reduced use plant materials promote sustainable limited resource medicinal plants, especially our South African context. Electronic ethnobotanical books online databases were used find studies focus phytoconstituent extraction processing enhance Modification synthesize daughter compounds facilitates an enhancement bioavailability. Based data collected through review, importance understanding properties targeted essential selecting required method. determines quality yield

Язык: Английский

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Computational Modeling of Pharmaceuticals with an Emphasis on Crossing the Blood–Brain Barrier

Pharmaceuticals, Год журнала: 2025, Номер 18(2), С. 217 - 217

Опубликована: Фев. 6, 2025

The discovery and development of new pharmaceutical drugs is a costly, time-consuming, highly manual process, with significant challenges in ensuring drug bioavailability at target sites. Computational techniques are employed design, particularly to predict the pharmacokinetic properties molecules. One major kinetic challenge central nervous system permeation through blood–brain barrier (BBB). Several different computational used evaluate both BBB permeability delivery. Methods such as quantitative structure–activity relationships, machine learning models, molecular dynamics simulations, end-point free energy calculations, or transporter models have pros cons for development, all contributing better understanding specific characteristic. Additionally, design (assisted not by computers) prodrug nanoparticle-based delivery systems can enhance leveraging enzymatic activation transporter-mediated uptake. Neuroactive peptide also relevant field since biopharmaceuticals on edge discovery. By integrating these formulation-based strategies, researchers rational BBB-permeable while minimizing off-target effects. This review valuable selectivity principles latest silico nanotechnological approaches improving CNS

Язык: Английский

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Exploring Ester Prodrugs: A Comprehensive Review of Approaches, Applications, and Methods

Pharmacology &amp Pharmacy, Год журнала: 2024, Номер 15(08), С. 269 - 284

Опубликована: Янв. 1, 2024

Язык: Английский

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The organoid modeling approach to understanding the mechanisms underlying neurodegeneration: A comprehensive review

Life Sciences, Год журнала: 2024, Номер 358, С. 123198 - 123198

Опубликована: Окт. 31, 2024

Язык: Английский

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