Exosomes in Autoimmune Diseases: A Review of Mechanisms and Diagnostic Applications

Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)

Опубликована: Янв. 17, 2025

Язык: Английский

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Chinese herbal medicines and its active ingredient wogonin can improve immune inflammation in psoriatic arthritis

International Immunopharmacology, Год журнала: 2025, Номер 147, С. 113984 - 113984

Опубликована: Янв. 5, 2025

Язык: Английский

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Gallic acid: a dietary metabolite’s therapeutic potential in the management of atherosclerotic cardiovascular disease

Frontiers in Pharmacology, Год журнала: 2025, Номер 15

Опубликована: Янв. 7, 2025

Atherosclerotic cardiovascular disease (ASCVD) causes significant morbidity and mortality globally. Most of the chemicals specifically target certain pathways minimally impact other diseases associated with ASCVD. Moreover, interactions these drugs can cause toxic reactions. Consequently, exploration multi-targeted safe medications for treating preventing ASCVD has become an increasingly popular trend. Gallic acid (GA), a natural secondary metabolite found in various fruits, plants, nuts, demonstrated potentials ASCVD, addition to its known antioxidant anti-inflammatory effects. It alleviates entire process atherosclerosis (AS) by reducing oxidative stress, improving endothelial dysfunction, inhibiting platelet activation aggregation. Additionally, GA treat ASCVD-related diseases, such as coronary heart (CHD) cerebral ischemia. However, pharmacological actions prevention treatment have not been comprehensively reviewed, which limits clinical development. This review primarily summarizes vitro vivo on related risk factors AS, it provides comprehensive overview toxicity, extraction, synthesis, pharmacokinetics, pharmaceutics GA,aimed enhance understanding applications further research

Язык: Английский

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Catharanthus roseus (L.) G. Don: A herb with the potential for curing breast cancer

Next research., Год журнала: 2025, Номер unknown, С. 100218 - 100218

Опубликована: Фев. 1, 2025

Язык: Английский

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Exploring the Molecular Interactions Between Ferroptosis and the Wnt/β-Catenin Signaling Pathway: Implications for Cancer and Disease Therapy

Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104674 - 104674

Опубликована: Фев. 1, 2025

Язык: Английский

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Btbd8 deficiency exacerbates bleomycin-induced pulmonary fibrosis in mice by enhancing myofibroblast accumulation and inflammatory responses

Experimental Cell Research, Год журнала: 2025, Номер unknown, С. 114494 - 114494

Опубликована: Март 1, 2025

Язык: Английский

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Novel impact of metal ion-induced cell death on diabetic cardiomyopathy pathogenesis and therapy

APOPTOSIS, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Язык: Английский

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Novel insights into taxane pharmacology: an update on drug resistance mechanisms, immunomodulation and drug delivery strategies

Drug Resistance Updates, Год журнала: 2025, Номер 81, С. 101223 - 101223

Опубликована: Март 8, 2025

Taxanes are effective in several solid tumors. Paclitaxel, the main clinically available taxane, was approved early nineties, for treatment of ovarian cancer and later on, together with analogs docetaxel cabazitaxel, other malignancies. By interfering microtubule function impairing separation sister cells at mitosis, taxanes act as antimitotic agents, thereby counteracting high proliferation rate cells. The action goes beyond their because cellular targets, microtubules, participate multiple processes such intracellular transport cell shape maintenance. clinical efficacy is limited by development resistance mechanisms. Among these, extracellular vesicles have emerged new players. In addition, taxane metronomic schedules shows an impact on tumor microenvironment reflected antiangiogenic immunomodulatory effects, aspect growing interest considering inclusion regimens immunotherapeutics. Preclinical studies paved bases synergistic combinations both conventional targeted agents. A variety drug delivery strategies provided novel opportunities to increase activity. ability orchestrate different effects amenable modulation suggests options improve cures lethal

Язык: Английский

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Advances in sepsis research: Insights into signaling pathways, organ failure, and emerging intervention strategies

Experimental and Molecular Pathology, Год журнала: 2025, Номер 142, С. 104963 - 104963

Опубликована: Март 27, 2025

Язык: Английский

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The Role of Non-coding RNAs in Diabetic Retinopathy: Mechanistic Insights and Therapeutic Potential

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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