Cited by Investigating the NF-κB Signaling Pathway in Heart Failure: Exploring Potential Therapeutic Approaches

Exosomes in Autoimmune Diseases: A Review of Mechanisms and Diagnostic Applications DOI

Lina Duan,

Wanying Lin, Yi Zhang

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: Jan. 17, 2025

Language: Английский

Citations

Chinese herbal medicines and its active ingredient wogonin can improve immune inflammation in psoriatic arthritis DOI

Xianheng Zhang, Jian Liu, Xiang Ding

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 113984 - 113984

Published: Jan. 5, 2025

Language: Английский

Citations

Gallic acid: a dietary metabolite’s therapeutic potential in the management of atherosclerotic cardiovascular disease DOI

Xiaolan Zhao,

Zhanxue Cao,

Ke-Di Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Atherosclerotic cardiovascular disease (ASCVD) causes significant morbidity and mortality globally. Most of the chemicals specifically target certain pathways minimally impact other diseases associated with ASCVD. Moreover, interactions these drugs can cause toxic reactions. Consequently, exploration multi-targeted safe medications for treating preventing ASCVD has become an increasingly popular trend. Gallic acid (GA), a natural secondary metabolite found in various fruits, plants, nuts, demonstrated potentials ASCVD, addition to its known antioxidant anti-inflammatory effects. It alleviates entire process atherosclerosis (AS) by reducing oxidative stress, improving endothelial dysfunction, inhibiting platelet activation aggregation. Additionally, GA treat ASCVD-related diseases, such as coronary heart (CHD) cerebral ischemia. However, pharmacological actions prevention treatment have not been comprehensively reviewed, which limits clinical development. This review primarily summarizes vitro vivo on related risk factors AS, it provides comprehensive overview toxicity, extraction, synthesis, pharmacokinetics, pharmaceutics GA,aimed enhance understanding applications further research

Language: Английский

Citations

Catharanthus roseus (L.) G. Don: A herb with the potential for curing breast cancer DOI

Selvarajah Saman,

Aqsa Hanif,

Sawsan S. Al-Rawi

et al.

Next research., Journal Year: 2025, Volume and Issue: unknown, P. 100218 - 100218

Published: Feb. 1, 2025

Language: Английский

Citations

Exploring the Molecular Interactions Between Ferroptosis and the Wnt/β-Catenin Signaling Pathway: Implications for Cancer and Disease Therapy DOI

Hui Jia,

Che Bian,

Yi Chang

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104674 - 104674

Published: Feb. 1, 2025

Language: Английский

Citations

Btbd8 deficiency exacerbates bleomycin-induced pulmonary fibrosis in mice by enhancing myofibroblast accumulation and inflammatory responses DOI

Xiaoqiong Yang,

Qiman Dong,

Xingyuan Tong

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114494 - 114494

Published: March 1, 2025

Language: Английский

Citations

Novel impact of metal ion-induced cell death on diabetic cardiomyopathy pathogenesis and therapy DOI

Jingjing Jiang,

Shengnan Hu, Kaibo Hu

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

Citations

Novel insights into taxane pharmacology: an update on drug resistance mechanisms, immunomodulation and drug delivery strategies DOI

Giovanni Luca Beretta, Giuliana Cassinelli, Giacomina Rossi

et al.

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: 81, P. 101223 - 101223

Published: March 8, 2025

Taxanes are effective in several solid tumors. Paclitaxel, the main clinically available taxane, was approved early nineties, for treatment of ovarian cancer and later on, together with analogs docetaxel cabazitaxel, other malignancies. By interfering microtubule function impairing separation sister cells at mitosis, taxanes act as antimitotic agents, thereby counteracting high proliferation rate cells. The action goes beyond their because cellular targets, microtubules, participate multiple processes such intracellular transport cell shape maintenance. clinical efficacy is limited by development resistance mechanisms. Among these, extracellular vesicles have emerged new players. In addition, taxane metronomic schedules shows an impact on tumor microenvironment reflected antiangiogenic immunomodulatory effects, aspect growing interest considering inclusion regimens immunotherapeutics. Preclinical studies paved bases synergistic combinations both conventional targeted agents. A variety drug delivery strategies provided novel opportunities to increase activity. ability orchestrate different effects amenable modulation suggests options improve cures lethal

Language: Английский

Citations

Advances in sepsis research: Insights into signaling pathways, organ failure, and emerging intervention strategies DOI

Yehua Li, Siying Ren,

Shenao Zhou

et al.

Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104963 - 104963

Published: March 27, 2025

Language: Английский

Citations

The Role of Non-coding RNAs in Diabetic Retinopathy: Mechanistic Insights and Therapeutic Potential DOI

Zhuan Zuo,

Ni Li, Qian Zhang

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations