Research Progress on Chaperone Mediated Autophagy in Digestive System Diseases

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(01), С. 1010 - 1018

Опубликована: Янв. 1, 2025

Язык: Английский

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Extensive Review of Nanomedicine Strategies Targeting the Tumor Microenvironment in PDAC

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 3379 - 3406

Опубликована: Март 1, 2025

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers in world, mainly because its powerful pro-connective tissue proliferation matrix and immunosuppressive tumor microenvironment (TME), which promote progression metastasis. In addition, extracellular leads to vascular collapse, increased interstitial fluid pressure, obstruction lymphatic return, thereby hindering effective drug delivery, deep penetration, immune cell infiltration. Therefore, reshaping TME enhance perfusion, increase reverse suppression has become a key therapeutic strategy. Traditional therapies for PDAC, including surgery, radiation, chemotherapy, face significant limitations. Surgery challenging due location growth, while chemotherapy radiation are hindered by dense TME. recent years, advancement nanotechnology provided new opportunities improve efficacy. Nanoscale delivery systems (NDDSs) provide several advantages, improved stability vivo, enhanced reduced systemic toxicity. However, clinical translation PDAC therapy faces challenges. These include need precise targeting control over release, potential responses nanocarriers, scalability cost-effectiveness production. This article provides an overview latest nanobased methods achieving better outcomes overcoming resistance. We pay special attention TME-targeted context discuss advantages limitations current strategies, emphasize promising developments. By emphasizing enormous NDDSs improving treatment patients with critically discussing traditional challenges faced breakthroughs, our review paves way future research this rapidly developing field.

Язык: Английский

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Chaihu Guizhi Ganjiang Decoction ameliorates chronic pancreatitis by modulating the SK1/S1P signaling pathway

Journal of Natural Medicines, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Язык: Английский

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Novel Tubeimoside I liposomal drug delivery system in combination with gemcitabine for the treatment of pancreatic cancer

Nanomedicine, Год журнала: 2024, Номер 19(24), С. 1977 - 1993

Опубликована: Сен. 3, 2024

Aim: To evaluate the anti-pancreatic cancer effect of novel Tubeimoside I multifunctional liposomes combined with gemcitabine.

Язык: Английский

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M2pep-Tasquinimod Ameliorates Chronic Pancreatitis Via Targeted Inhibition of M2-Like Macrophage Polarization

Опубликована: Янв. 1, 2024

Язык: Английский

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