M2pep-Tasquinimod Ameliorates Chronic Pancreatitis Via Targeted Inhibition of M2-Like Macrophage Polarization DOI
Xin Kong,

Xufeng Tao,

Hong Xiang

et al.

Published: Jan. 1, 2024

Language: Английский

Research Progress on Chaperone Mediated Autophagy in Digestive System Diseases DOI

忠标 李

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 1010 - 1018

Published: Jan. 1, 2025

Language: Английский

Citations

0
Extensive Review of Nanomedicine Strategies Targeting the Tumor Microenvironment in PDAC DOI Creative Commons

Xing Liu,

Yidan Shao,

Yunjiang Li

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 3379 - 3406

Published: March 1, 2025

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers in world, mainly because its powerful pro-connective tissue proliferation matrix and immunosuppressive tumor microenvironment (TME), which promote progression metastasis. In addition, extracellular leads to vascular collapse, increased interstitial fluid pressure, obstruction lymphatic return, thereby hindering effective drug delivery, deep penetration, immune cell infiltration. Therefore, reshaping TME enhance perfusion, increase reverse suppression has become a key therapeutic strategy. Traditional therapies for PDAC, including surgery, radiation, chemotherapy, face significant limitations. Surgery challenging due location growth, while chemotherapy radiation are hindered by dense TME. recent years, advancement nanotechnology provided new opportunities improve efficacy. Nanoscale delivery systems (NDDSs) provide several advantages, improved stability vivo, enhanced reduced systemic toxicity. However, clinical translation PDAC therapy faces challenges. These include need precise targeting control over release, potential responses nanocarriers, scalability cost-effectiveness production. This article provides an overview latest nanobased methods achieving better outcomes overcoming resistance. We pay special attention TME-targeted context discuss advantages limitations current strategies, emphasize promising developments. By emphasizing enormous NDDSs improving treatment patients with critically discussing traditional challenges faced breakthroughs, our review paves way future research this rapidly developing field.

Language: Английский

Citations

0
Chaihu Guizhi Ganjiang Decoction ameliorates chronic pancreatitis by modulating the SK1/S1P signaling pathway DOI

Guo‐Wang Yao,

Caixia Li,

Yuxing Fan

et al.

Journal of Natural Medicines, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Language: Английский

Citations

0
Novel Tubeimoside I liposomal drug delivery system in combination with gemcitabine for the treatment of pancreatic cancer DOI
S. Li, Yuansheng Liu, Xiaojun Sui

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(24), P. 1977 - 1993

Published: Sept. 3, 2024

Aim: To evaluate the anti-pancreatic cancer effect of novel Tubeimoside I multifunctional liposomes combined with gemcitabine.

Language: Английский

Citations

1
M2pep-Tasquinimod Ameliorates Chronic Pancreatitis Via Targeted Inhibition of M2-Like Macrophage Polarization DOI
Xin Kong,

Xufeng Tao,

Hong Xiang

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0