A decade of research effort in synthesis, biological activity assessments, and mechanistic investigations of sulfamethazine‐incorporating molecules

Archiv der Pharmazie, Год журнала: 2025, Номер 358(3)

Опубликована: Март 1, 2025

Abstract Because of its importance in medicinal chemistry, scientific researchers have been interested incorporating sulfamethazine developing biologically active candidates. To achieve this, several synthetic approaches adopted. The adopted included condensation with electrophilic reactants, coupling nucleophilic aromatics and methylene compounds, Knoevenagel condensation, Doebner Miller reaction, microwave‐assisted click cycloaddition, green reaction routes, multicomponent reaction. Linking this molecular scaffold to a variety heterocycles the last 10 years furnished set potential anti‐inflammatory, antiviral, anticancer, antiparkinsonian, neuroprotective, antidiabetic candidates targeting H5N1 NA, epidermal growth factor receptor, acetylcholinesterase (AChE), butylcholinesterase (BChE), human carbonic anhydrase ( h CA), α‐amylase, α‐glucosidase. This review reports all approaches, biological activities studied, structure‐activity relationship analyses, mechanistic investigations reported organic sulfamethazine‐incorporating molecules throughout 2015–2024, based on information retrieved from three search engines: Scopus, PubMed, Google Scholar.

Язык: Английский

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The role of the sulfaguanidine molecular scaffold in drug design and development

Archiv der Pharmazie, Год журнала: 2024, Номер unknown

Опубликована: Дек. 10, 2024

Abstract Developing new molecular entities is one of the most emerging research areas in field Medicinal Chemistry. Over past few years, rigorous has been conducted on sulfaguanidine‐linked synthetic molecules because their promising potential several biological activities. Sulfaguanidine actively incorporated design anticancer, antimicrobial, antidiabetic, antiparkinsonian, anti‐inflammatory, and antiviral candidates. The construction these effective candidates adopted many chemical approaches. A number prepared compounds displayed results that merit further investigations for development medications. This review summarizes different strategies reported activities throughout 2020–2024.

Язык: Английский

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Synthesis and Reactions of 2-Amino-3-Cyanopyridine Derivatives (A Review)

Russian Journal of Organic Chemistry, Год журнала: 2024, Номер 60(11), С. 2170 - 2227

Опубликована: Ноя. 1, 2024

Язык: Английский

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