Oligosaccharide feed supplementation reduces plasma insulin in geldings with Equine Metabolic Syndrome DOI Creative Commons
Alexandra von Münchow,

Sarah Torp Yttergren,

Rasmus Riemer Jakobsen

и другие.

Frontiers in Microbiomes, Год журнала: 2023, Номер 2

Опубликована: Авг. 2, 2023

Background The prevalence of Equine Metabolic Syndrome and insulin dysregulation is increasing in the horse population. Insulin a risk factor for laminitis, which has significant welfare consequences horse. Current treatment strategies have variable effects on sensitivity. Findings suggest that gut microbiota plays an important role gastrointestinal barrier protection metabolic diseases. Dietary supplementation with oligosaccharides been shown to increase production short-chain fatty acids induce changes microbiota, Objectives We hypothesized dietary oligosaccharide would ameliorate horses Syndrome. Study design Fifteen were included cross-over study including two feed supplementations periods or calcium carbonate. Before after each period plasma insulin, endotoxin, serum amyloid A, blood glucose concentrations measured during oral sugar test fecal samples collected. Results Oligosaccharide significantly reduced geldings ( p = 0.02). Overall, none dominating bacterias changed relative Δ-abundance. In mares, Akkermansia genus Clostridiaceae family more abundant. Within-sample bacterial diversity > 60 mIU/L was greater when compared < mIU/L. Horses previous laminitis had beta diversity. Main limitations Cut-off values supplementation/placebo dosing instead by g/kg body weight; owner compliance; single sample test; inter-horse variation Conclusions This demonstrated could improve suggesting sex susceptibility might be consider. Additionally, tendency reduction obesity-associated bacteria observed. Furthermore, dependent status concentrations. However, studies are needed management

Язык: Английский

A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation DOI Creative Commons

Ziqi Ma,

Tao Zuo, Norbert Frey

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Сен. 23, 2024

Язык: Английский

Процитировано

20
Human Breast Milk: The Role of Its Microbiota and Metabolites in Infant Health DOI
Meng Zhang, Hui Qiao,

Shuwei Yang

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(19), С. 10665 - 10678

Опубликована: Май 1, 2024

This review explores the role of microorganisms and metabolites in human breast milk their impact on neonatal health. Breast serves as both a primary source nutrition for newborns contributes to development maturation digestive, immunological, neurological systems. It has potential reduce risks infections, allergies, asthma. As our understanding properties advances, there is growing interest incorporating its benefits into personalized infant strategies, particularly situations which breastfeeding not an option. Future formula products are expected emulate composition advantages milk, aligning with evolving nutrition. The long-term health implications still under investigation.

Язык: Английский

Процитировано

10
Human milk oligosaccharides: bridging the gap in intestinal microbiota between mothers and infants DOI Creative Commons
Wen Sun, Lin Tao, Chen Qian

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 14

Опубликована: Янв. 6, 2025

Breast milk is an essential source of infant nutrition. It also a vital determinant the structure and function intestinal microbial community, it connects mother microbiota. Human oligosaccharides (HMOs) are critical component in breast milk. HMOs can reach baby's colon entirely from become fermentable substrate for some microorganisms. enhance mucosal barrier affect host through immune function, which has therapeutic effect on specific diseases, such as necrotizing enterocolitis. In addition, changes microbiota reflect maternal link between infants related to Through breastfeeding, jointly bacteria. Therefore, positively influence establishment balance ensure function. be used supplement alternative therapy diseases.

Язык: Английский

Процитировано

1
Clinical Studies on the Supplementation of Manufactured Human Milk Oligosaccharides: A Systematic Review DOI Open Access
Yannik Bernd Schönknecht,

María Virginia Moreno Tovar,

Stina Rikke Jensen

и другие.

Nutrients, Год журнала: 2023, Номер 15(16), С. 3622 - 3622

Опубликована: Авг. 17, 2023

Human milk oligosaccharides (HMOs) are a major component of human milk. They associated with multiple health benefits and manufactured on large scale for their addition to different food products. In this systematic review, we evaluate the outcomes published clinical trials involving supplementation HMOs. We screened PubMed database Cochrane Library, identifying 26 relevant five publications describing follow-up studies. The varied in study populations, including healthy term infants, infants medical indications, children, adults. tested eight HMO structures individually or as blends varying doses. All included safety tolerance assessments, some also assessed growth, stool characteristics, infections, gut microbiome composition, microbial metabolites, biomarkers. studies consistently found that was safe well tolerated. Infant reported shift towards those observed breastfed intestinal immune markers. Beneficial system effects have been other populations following supplementation. Further needed substantiate understand structure dose dependency.

Язык: Английский

Процитировано

20
Bifidobacterium breve Protects the Intestinal Epithelium and Mitigates Inflammation in Colitis via Regulating the Gut Microbiota–Cholic Acid Pathway DOI
Yaqian Li, Hongtao Xu,

Liuyang Zhou

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(7), С. 3572 - 3583

Опубликована: Фев. 9, 2024

In this study, we aimed to explore the protective effects of Bifidobacterium in colitis mice and potential mechanisms. Results showed that breve (B. breve) effectively colonized intestinal tract alleviated symptoms by reducing disease activity index. Moreover, B. mitigated epithelial cell damage, inhibited pro-inflammatory factors, upregulated tight junction (TJ)-proteins. Gut microbiota metabolome analysis found boosted bile acid-regulating genera (such as Clostridium sensu stricto 1), which promoted acid deconjugation intestine. Notably, cholic (CA) was closely associated with expression levels inflammatory factors TJ-proteins (p < 0.05). Our vitro experiments further confirmed CA (20.24 ± 4.53 pg/mL) contributed inhibition lipopolysaccharide-induced tumor necrosis factor-α (49.32 5.27 enhanced (Occludin Claudin-1) MUC2. This study suggested could be a probiotic candidate for use infant foods.

Язык: Английский

Процитировано

7
Gut microbiota: A key role for human milk oligosaccharides in regulating host health early in life DOI

Qingxue Chen,

Ma Xinming,

Zhengtao Guo

и другие.

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2024, Номер 23(5)

Опубликована: Авг. 21, 2024

Human milk oligosaccharides (HMOs) are an evolutionarily significant advantage bestowed by mothers for facilitating the development of infant's gut microbiota. They can avoid absorption in stomach and small intestine, reaching colon successfully, where they engage close interactions with microbes. This process also enables HMOs to exert additional prebiotic effects, including regulating mucus layer, promoting physical growth brain development, as well preventing mitigating conditions such NEC, allergies, diarrhea. Here, we comprehensively review primary ways which microbiota, Bifidobacteria other genera, utilize HMOs, classify them into five central pathways. Furthermore, emphasize metabolic benefits bacteria consuming particularly recently identified intrinsic link between conversion tryptophan indole its derivatives. We examine extensive probiotic roles their recent research advancements, specifically concentrating on unsummarized role interaction microbiota becomes crucial. Additionally, delve principal tools used functional mining new HMOs. In conclusion, our study presents a thorough analysis mechanism emphasizing cooperative utilization provides overview subsequent effects this interaction. insights will inform mechanisms function.

Язык: Английский

Процитировано

7
CRISPR-Cas-based identification of a sialylated human milk oligosaccharides utilization cluster in the infant gut commensal Bacteroides dorei DOI Creative Commons
Sivan Kijner, Dena Ennis,

Shimrit Shmorak

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Янв. 2, 2024

Abstract The infant gut microbiome is impacted by early-life feeding, as human milk oligosaccharides (HMOs) found in breastmilk cannot be digested infants and serve nutrients for their bacteria. While the vast majority of HMO-utilization research has focused on Bifidobacterium species, recent studies have suggested additional HMO-utilizers, mostly Bacteroides , yet utilization mechanism poorly characterized. Here, we investigate dorei isolates from breastfed-infants identify that polysaccharide locus (PUL) 33 enables B. to utilize sialylated HMOs. We perform transcriptional profiling identity upregulated genes when growing Using CRISPR-Cas12 knock-out four PUL33 genes, combined with complementation assays, GH33 critical gene HMO-utilization. This demonstration an system species isolated opens way further characterization such systems, better understand gut.

Язык: Английский

Процитировано

6
2′-Fucosyllactose Promotes Colonization of Akkermansia muciniphila and Prevents Colitis In Vitro and in Mice DOI
Xiaoxia Liu, Bowei Zhang,

Yunhui Zhang

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(9), С. 4765 - 4776

Опубликована: Фев. 23, 2024

Akkermansia muciniphila is a potential candidate for ulcerative colitis prevention. Considering that it utilizes 2′-fucosyllactose (2′FL) growth, 2′FL can be used to enrich the abundance of A. in feces. However, whether crosswalk between and promote intestinal colonization remains unclear. In this study, we explored effect underlying mechanism on vitro vivo as well its alleviating colitis. Our results revealed serve carbon source support growth increase cell-surface hydrophobicity expression genes coding fibronectin-binding autotransporter adhesin adhesion Caco2/HT29 methotrexate (MTX) cells but not galactooligosaccharides (GOS) glucose. Moreover, could host mucin formation MTX GOS Furthermore, significantly gut alleviate mice. Overall, interplay expected provide an advantageous ecological niche so confer further health benefits against

Язык: Английский

Процитировано

6
The neonatal gut microbiome in health and disease DOI Creative Commons
Geoffrey A. Preidis

Gut Microbes, Год журнала: 2025, Номер 17(1)

Опубликована: Янв. 27, 2025

Язык: Английский

Процитировано

0
Recent trends in human milk oligosaccharides: New synthesis technology, regulatory effects, and mechanisms of non‐intestinal functions DOI

Qingxue Chen,

Xiangxin Wang, Peng Zhang

и другие.

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2025, Номер 24(2)

Опубликована: Март 1, 2025

Abstract Recently, the non‐intestinal functions of human milk oligosaccharides (HMOs) have been widely documented, including their roles in promoting brain development and growth, as well ameliorating anxiety, allergies, obesity. Understanding mechanisms action is becoming increasingly critical. Furthermore, these effects are frequently associated with type structure HMOs. As an innovative technology, “plant factory” expected to complement traditional synthesis technology. This study reviews novel techniques. Particular emphasis placed on processes, advantages, limitations technology can express genes related HMO instantaneously plant leaves, thereby enabling rapid cost‐effective generation However, remains underdeveloped, challenges low yield unsustainable production must be addressed. we present overview most recent clinical preclinical studies review emphasizes underlying HMOs primarily exert through cleavage beneficial monomer components, metabolism produce advantageous metabolites, regulation immune responses.

Язык: Английский

Процитировано

0