Biology,
Год журнала:
2024,
Номер
13(11), С. 855 - 855
Опубликована: Окт. 23, 2024
Milk
oligosaccharides
are
complex
carbohydrates
composed
of
various
monosaccharide
units
linked
together
by
glycosidic
bonds.
They
play
an
essential
role
in
promoting
gut
health
fostering
beneficial
bacteria,
supporting
the
development
immune
system,
and
protecting
against
infections
diseases.
This
work
compared
oligosaccharide
profiles
widely
utilized
breeds
such
as
Holstein
Ayrshire
(Nordic
Red),
with
native
Northern
Finncattle,
which
is
considered
endangered
breed.
Oligosaccharides
were
extracted
from
milk
analyzed
liquid
chromatography-mass
spectrometry.
The
composition
relative
abundance
identified
characterized
compared.
statistical
analyses
showed
that
neutral,
sialylated,
fucosylated
vary
among
breeds.
Finncattle
formed
a
cluster,
while
Holstein's
profile
shared
features
both
Finncattle.
had
lowest
OS
three
breeds,
having
highest
content
followed
relatively
higher
sialylated
over
neutral
important
feature
should
be
preserved.
good
candidate
to
recover
more
diverse
potential
implications
for
consumers.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(19), С. 10665 - 10678
Опубликована: Май 1, 2024
This
review
explores
the
role
of
microorganisms
and
metabolites
in
human
breast
milk
their
impact
on
neonatal
health.
Breast
serves
as
both
a
primary
source
nutrition
for
newborns
contributes
to
development
maturation
digestive,
immunological,
neurological
systems.
It
has
potential
reduce
risks
infections,
allergies,
asthma.
As
our
understanding
properties
advances,
there
is
growing
interest
incorporating
its
benefits
into
personalized
infant
strategies,
particularly
situations
which
breastfeeding
not
an
option.
Future
formula
products
are
expected
emulate
composition
advantages
milk,
aligning
with
evolving
nutrition.
The
long-term
health
implications
still
under
investigation.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(7), С. 3572 - 3583
Опубликована: Фев. 9, 2024
In
this
study,
we
aimed
to
explore
the
protective
effects
of
Bifidobacterium
in
colitis
mice
and
potential
mechanisms.
Results
showed
that
breve
(B.
breve)
effectively
colonized
intestinal
tract
alleviated
symptoms
by
reducing
disease
activity
index.
Moreover,
B.
mitigated
epithelial
cell
damage,
inhibited
pro-inflammatory
factors,
upregulated
tight
junction
(TJ)-proteins.
Gut
microbiota
metabolome
analysis
found
boosted
bile
acid-regulating
genera
(such
as
Clostridium
sensu
stricto
1),
which
promoted
acid
deconjugation
intestine.
Notably,
cholic
(CA)
was
closely
associated
with
expression
levels
inflammatory
factors
TJ-proteins
(p
<
0.05).
Our
vitro
experiments
further
confirmed
CA
(20.24
±
4.53
pg/mL)
contributed
inhibition
lipopolysaccharide-induced
tumor
necrosis
factor-α
(49.32
5.27
enhanced
(Occludin
Claudin-1)
MUC2.
This
study
suggested
could
be
a
probiotic
candidate
for
use
infant
foods.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
14
Опубликована: Янв. 6, 2025
Breast
milk
is
an
essential
source
of
infant
nutrition.
It
also
a
vital
determinant
the
structure
and
function
intestinal
microbial
community,
it
connects
mother
microbiota.
Human
oligosaccharides
(HMOs)
are
critical
component
in
breast
milk.
HMOs
can
reach
baby's
colon
entirely
from
become
fermentable
substrate
for
some
microorganisms.
enhance
mucosal
barrier
affect
host
through
immune
function,
which
has
therapeutic
effect
on
specific
diseases,
such
as
necrotizing
enterocolitis.
In
addition,
changes
microbiota
reflect
maternal
link
between
infants
related
to
Through
breastfeeding,
jointly
bacteria.
Therefore,
positively
influence
establishment
balance
ensure
function.
be
used
supplement
alternative
therapy
diseases.
Nutrients,
Год журнала:
2023,
Номер
15(16), С. 3622 - 3622
Опубликована: Авг. 17, 2023
Human
milk
oligosaccharides
(HMOs)
are
a
major
component
of
human
milk.
They
associated
with
multiple
health
benefits
and
manufactured
on
large
scale
for
their
addition
to
different
food
products.
In
this
systematic
review,
we
evaluate
the
outcomes
published
clinical
trials
involving
supplementation
HMOs.
We
screened
PubMed
database
Cochrane
Library,
identifying
26
relevant
five
publications
describing
follow-up
studies.
The
varied
in
study
populations,
including
healthy
term
infants,
infants
medical
indications,
children,
adults.
tested
eight
HMO
structures
individually
or
as
blends
varying
doses.
All
included
safety
tolerance
assessments,
some
also
assessed
growth,
stool
characteristics,
infections,
gut
microbiome
composition,
microbial
metabolites,
biomarkers.
studies
consistently
found
that
was
safe
well
tolerated.
Infant
reported
shift
towards
those
observed
breastfed
intestinal
immune
markers.
Beneficial
system
effects
have
been
other
populations
following
supplementation.
Further
needed
substantiate
understand
structure
dose
dependency.
Food Chemistry X,
Год журнала:
2024,
Номер
23, С. 101611 - 101611
Опубликована: Июль 2, 2024
Mounting
evidence
supports
the
potential
of
dietary
bioactives
to
reduce
chronic
disease
risk.
N-trans-caffeoyltyramine
(NCT)
and
N-trans-feruloyltyramine
(NFT)
have
been
hypothesized
drive
regulation
gut
permeability,
but
these
components
not
yet
studied
in
context
human
microbiome.
This
work
examined
whether
purified
NCT
NFT,
or
a
hemp
hull
product
containing
NFT
(Brightseed®
Bio
Gut
Fiber™),
can
impact
microbiome
using
an
vitro
fermentation
assay.
Representative
microbiomes
were
treated
with
Fiber™
compared
starch
methylcellulose,
as
controls,
vitro.
Stronger
changes
exerted
by
Fiber™,
NCT,
NFT.
Communities
saw
increased
productivity
diversity.
We
found
dose-dependent
effect
on
microbial
communities.
Here,
we
describe
novel
for
hemp-derived
shape
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 2, 2024
Abstract
The
infant
gut
microbiome
is
impacted
by
early-life
feeding,
as
human
milk
oligosaccharides
(HMOs)
found
in
breastmilk
cannot
be
digested
infants
and
serve
nutrients
for
their
bacteria.
While
the
vast
majority
of
HMO-utilization
research
has
focused
on
Bifidobacterium
species,
recent
studies
have
suggested
additional
HMO-utilizers,
mostly
Bacteroides
,
yet
utilization
mechanism
poorly
characterized.
Here,
we
investigate
dorei
isolates
from
breastfed-infants
identify
that
polysaccharide
locus
(PUL)
33
enables
B.
to
utilize
sialylated
HMOs.
We
perform
transcriptional
profiling
identity
upregulated
genes
when
growing
Using
CRISPR-Cas12
knock-out
four
PUL33
genes,
combined
with
complementation
assays,
GH33
critical
gene
HMO-utilization.
This
demonstration
an
system
species
isolated
opens
way
further
characterization
such
systems,
better
understand
gut.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(9), С. 4765 - 4776
Опубликована: Фев. 23, 2024
Akkermansia
muciniphila
is
a
potential
candidate
for
ulcerative
colitis
prevention.
Considering
that
it
utilizes
2′-fucosyllactose
(2′FL)
growth,
2′FL
can
be
used
to
enrich
the
abundance
of
A.
in
feces.
However,
whether
crosswalk
between
and
promote
intestinal
colonization
remains
unclear.
In
this
study,
we
explored
effect
underlying
mechanism
on
vitro
vivo
as
well
its
alleviating
colitis.
Our
results
revealed
serve
carbon
source
support
growth
increase
cell-surface
hydrophobicity
expression
genes
coding
fibronectin-binding
autotransporter
adhesin
adhesion
Caco2/HT29
methotrexate
(MTX)
cells
but
not
galactooligosaccharides
(GOS)
glucose.
Moreover,
could
host
mucin
formation
MTX
GOS
Furthermore,
significantly
gut
alleviate
mice.
Overall,
interplay
expected
provide
an
advantageous
ecological
niche
so
confer
further
health
benefits
against
Comprehensive Reviews in Food Science and Food Safety,
Год журнала:
2024,
Номер
23(5)
Опубликована: Авг. 21, 2024
Human
milk
oligosaccharides
(HMOs)
are
an
evolutionarily
significant
advantage
bestowed
by
mothers
for
facilitating
the
development
of
infant's
gut
microbiota.
They
can
avoid
absorption
in
stomach
and
small
intestine,
reaching
colon
successfully,
where
they
engage
close
interactions
with
microbes.
This
process
also
enables
HMOs
to
exert
additional
prebiotic
effects,
including
regulating
mucus
layer,
promoting
physical
growth
brain
development,
as
well
preventing
mitigating
conditions
such
NEC,
allergies,
diarrhea.
Here,
we
comprehensively
review
primary
ways
which
microbiota,
Bifidobacteria
other
genera,
utilize
HMOs,
classify
them
into
five
central
pathways.
Furthermore,
emphasize
metabolic
benefits
bacteria
consuming
particularly
recently
identified
intrinsic
link
between
conversion
tryptophan
indole
its
derivatives.
We
examine
extensive
probiotic
roles
their
recent
research
advancements,
specifically
concentrating
on
unsummarized
role
interaction
microbiota
becomes
crucial.
Additionally,
delve
principal
tools
used
functional
mining
new
HMOs.
In
conclusion,
our
study
presents
a
thorough
analysis
mechanism
emphasizing
cooperative
utilization
provides
overview
subsequent
effects
this
interaction.
insights
will
inform
mechanisms
function.
