Elsevier eBooks, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Theranostics, Год журнала: 2024, Номер 14(9), С. 3760 - 3776
Опубликована: Янв. 1, 2024
Currently, there are occasional reports of health problems caused by sleep deprivation (SD). However, to date, remains a lack in-depth research regarding the effects SD on growth and development oocytes in females. The present work aimed investigate whether influences ovarian folliculogenesis adolescent female mice.
Язык: Английский
Процитировано
2
Gut Microbes, Год журнала: 2024, Номер 16(1)
Опубликована: Окт. 16, 2024
High-fat diet (HFD) has been linked to female infertility. However, the specific age at which HFD impacts ovarian function and underlying mechanisms remain poorly understood. Here, we administered a mice various developmental stages: pre-puberty (4 weeks old), post-puberty (6 young adult (9 middle (32 old). Our observations indicated that was most significantly compromised when initiated post-puberty. Consequently, were chosen for further investigation. Through transplantation of fecal bacteria from on normal diet, confirmed gut microbiota dysbiosis contributed HFD-induced deteriorated fertility disrupted estradiol synthesis. Utilizing untargeted targeted metabolomics analyses, identified L-saccharopine as key metabolite, enriched in feces, serum, ovaries HFD-FMT mice. Subsequent
Язык: Английский
Процитировано
1
Free Radical Biology and Medicine, Год журнала: 2024, Номер 226, С. 330 - 347
Опубликована: Ноя. 14, 2024
Polycystic ovary syndrome (PCOS) is a common endocrine disorder marked by ovarian dysfunction and metabolic abnormality. This study explores the therapeutic potential of leonurine (SCM-198) in PCOS. Our results show that SCM-198 treatment significantly improved function, hormone disorders insulin resistance while reducing granulosa cell ferroptosis. provides first evidence modulates gut microbiota composition, increases abundance Christensenella minuta, boosts butyrate levels. Transcriptomic metabolomic analyses revealed PCOS patients exhibit ferroptosis decreased levels follicular fluid. Butyrate was shown to alleviate cells via SLC7A11/TXNRD1/GPX4 pathway, as confirmed vitro with KGN cells. The mechanism management microbiota-ovary axis involves enhancement its metabolites. intervention improves function alleviates symptoms targeting
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12643 - 12643
Опубликована: Ноя. 25, 2024
Ovarian dysfunction caused by aging restricts female reproductive capacity and is accompanied oxidative stress impaired autophagy. Recent studies have shown that trehalose (Tre) can activate autophagy antioxidant effects. However, whether Tre be used to attenuate ovarian remains unclear. Therefore, the anti-aging effects of on ovary were explored both in vivo vitro. D-galactose (D-gal) was administered i.p. daily (200 mg/kg body weight) for 8 weeks establish mouse model (n = 10). We found significantly reversed weight loss reduced number TUNEL-positive granulosa cells D-gal ovaries. elevated protein expression levels LC3-II, Parkin, PINK1, Beclin1, LAMP2 Mitochondrial-related proteins TOM20 COX IV increased administration. In vitro further supported these findings, showing treatment SA-β-gal PI-positive cells, decreased ROS cultured cells. Thus, alleviates activating mitophagy reducing stress, suggesting its potential as an agent health.
Язык: Английский
Процитировано
1
Critical Reviews in Food Science and Nutrition, Год журнала: 2024, Номер unknown, С. 1 - 13
Опубликована: Июнь 4, 2024
The global rise in life expectancy corresponds with a delay childbearing age among women. Ovaries, seen as the chronometers of female physiological aging, demonstrate features sped up evidenced by steady decline both quality and quantity ovarian follicles from birth. multifaceted pathogenesis aging has kindled intensive research interest biomedical pharmaceutical sectors. Novel studies underscore integral roles gut microbiota follicular development, lipid metabolism, hormonal regulation, forging nexus aging. In this review, we outline role function (follicular oocyte maturation, ovulation), compile present alterations associated age-related We also discuss potential strategies for alleviating perspective microbiota, such fecal transplantation probiotics.
Язык: Английский
Процитировано
0
Journal of Functional Foods, Год журнала: 2024, Номер 118, С. 106275 - 106275
Опубликована: Июнь 7, 2024
Язык: Английский
Процитировано
0
Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Июль 10, 2024
Extensive research efforts have been dedicated to elucidating the intricate pathways by which gastrointestinal microbiota and their metabolites exert influence on processes of bone formation. Nonetheless, a notable gap exists in literature concerning bibliometric analysis trends at nexus metabolism.
Язык: Английский
Процитировано
0
Phytomedicine, Год журнала: 2024, Номер 134, С. 155961 - 155961
Опубликована: Авг. 17, 2024
Язык: Английский
Процитировано
0
Bulletin of the Medical Institute REAVIZ (REHABILITATION DOCTOR AND HEALTH), Год журнала: 2024, Номер 14(4), С. 14 - 19
Опубликована: Окт. 12, 2024
Aging is a systemic process affecting all tissues of the body. In this study, choice scientific interest fell on paired gland, key structure female reproductive system – ovary. Objective : to carry out comparative analysis parameters thickness cerebral and cortical layers, as well protein membrane ovaries in women adolescence, elderly senile age. Materials methods . The results study 60 with normal pelvic dimensions without pathology organs was carried out. Group I included 28 victims adolescent age (16-20 years old), group II consisted 29 (56-74 III 27 (75-90 old). albumen both ovaries, were determined histological samples. Results A decrease medulla an increase albuminous period from adolescence old revealed. right ovary thinned by 3.76%, left 4.46%; substance 29.9%, 29.64% (p < 0,01). ovary, contrary, increases 48.23%, 50.21% From age, there tendency matter 0.95% 0.24% > 0,05), 1.5% 1.21% 0,05). At same time, shell becomes thicker 14.08%, 13.57% Conclusion obtained can become conditional "morphological standard" for certain norms diagnosis various diseases, expand understanding changes morphological picture woman's
Язык: Английский
Процитировано
0
Journal of genetics and genomics/Journal of Genetics and Genomics, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
0