From Gut to Brain: The Role of Gut Dysbiosis, Bacterial Amyloids, and Metabolic Disease in Alzheimer’s Disease
Pharmacological Research,
Год журнала:
2025,
Номер
unknown, С. 107693 - 107693
Опубликована: Март 1, 2025
Gut
microbial
dysbiosis,
or
altered
gut
communities,
in
Alzheimer's
Disease
suggests
a
pathogenic
role
for
inflammation
and
products
shaping
neuroinflammatory
environment.
Similarly,
metabolic
diseases,
such
as
obesity
diabetes,
are
also
associated
with
an
increased
risk
of
Disease.
As
the
landscape
shifts
during
inflammation,
turn
impacts
processes,
we
explore
how
these
interconnected
pathways
may
contribute
to
progression
Additionally,
discuss
bacterial
amyloids
produced
by
microbes,
which
exacerbate
amyloid
aggregation
brain
neurodegenerative
processes.
Furthermore,
highlight
potential
therapeutic
strategies
aimed
at
reducing
improving
health,
decreasing
content
means
mitigate
progression.
These
approaches,
targeting
gut-brain-metabolic
axis,
could
offer
promising
avenues
delaying
preventing
cognitive
decline
affected
individuals.
Язык: Английский
Unveiling the Therapeutic Potential of Banxia Xiexin Decoction in Alzheimer’s Disease: Insights From Network Pharmacology and Experimental Validation
Drug Design Development and Therapy,
Год журнала:
2025,
Номер
Volume 19, С. 2133 - 2155
Опубликована: Март 1, 2025
Alzheimer's
disease
(AD)
is
associated
with
various
pathological
states
for
which
there
no
effective
treatment.
First
documented
in
the
Eastern
Han
Dynasty's
medical
classic,
"Treatise
on
Febrile
and
Miscellaneous
Diseases"
(200-210
Anno
Domini),
Banxia
Xiexin
Decoction
(BXD)
stands
as
a
quintessential
approach
to
treating
spleen
ailments.
Recent
studies
have
shown
BXD's
effectiveness
mitigating
memory
impairment
AD.
Yet,
precise
mechanisms
underlying
action
against
AD
require
further
exploration.
To
explore
important
components
of
BXD
exerting
anti-AD
effects
molecular
using
network
pharmacology,
metabolomics
analysis,
vitro
vivo
validation
strategies.
Initially,
candidates
application
therapy
were
identified
through
extensive
database
searches,
followed
by
an
analysis
protein-protein
interactions
(PPI).
elucidate
therapeutic
pathways
AD,
we
engaged
Gene
Ontology
(GO)
enrichment
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
assessments.
Further,
delved
into
primary
constituents
ultra-high-pressure
liquid
chromatography
coupled
Q
Exactive
mass
spectrometry
docking
techniques.
Finally,
AD-associated
Aβ42-SY5Y
cells
APPswe/PS1dE9
(APP/PS1)
transgenic
mice
models
utilized
determine
activity
or
phenotypic
assays
analysis.
Our
findings
PI3K/Akt
signaling
central
effects.
Using
models,
found
be
mediated
suppression
neuroinflammation
apoptosis,
accompanied
activation
pathway.
observed
robust
changes
metabolite
levels
plasma
BXD-treated
APP/PS1
mice.
Through
systematic
data
experimental
validation,
advantages
fundamental
revealed.
These
underscore
promising
prospects
compelling
potential
BXD,
targets
pathway
inflammation,
strategy
improving
Язык: Английский
IL‐17A Induces Circadian Disruptions Through the Epigenetic Repression of BMAL1 in Mice With Alzheimer's Disease
Journal of Cellular and Molecular Medicine,
Год журнала:
2025,
Номер
29(7)
Опубликована: Апрель 1, 2025
ABSTRACT
Circadian
disruptions
and
neuroinflammation
impact
nearly
all
people
with
Alzheimer's
disease
(AD),
but
their
relationships
each
other
the
of
interaction
on
AD
remain
to
be
addressed.
Here,
we
found
that
amyloid
(A)‐β
treatment
downregulated
brain
muscle
aryl
hydrocarbon
receptor
nuclear
translocator‐like
(BMAL)
1
through
hypermethylation
its
promoter
region
in
HT22
cells
inhibition
DNA
methylation
ameliorated
circadian
rhythm
disorders
restored
BMAL1
protein
expression
by
reversing
APPswe/PSEN1dE9
(APP/PS1)
mice.
Critically,
increased
levels
interleukin
(IL)‐17A
contributed
downregulation
region,
thus
leading
APP/PS1
Moreover,
revealed
mitogen‐activated
kinase
(MAPK)
pathway
was
responsible
for
IL‐17A‐induced
methyltransferase
(DNMT)
upregulation.
Taken
together,
elucidate
a
new
mechanism
connecting
IL‐17A
altered
Bmal1
,
which
results
disturbances
an
mouse
model.
Язык: Английский
Research progress of cell senescence in Alzheimer's disease: mechanisms and therapy
European Journal of Pharmacology,
Год журнала:
2025,
Номер
unknown, С. 177697 - 177697
Опубликована: Май 1, 2025
Язык: Английский
Novelties on Neuroinflammation in Alzheimer’s Disease–Focus on Gut and Oral Microbiota Involvement
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11272 - 11272
Опубликована: Окт. 19, 2024
Recent
studies
underscore
the
role
of
gut
and
oral
microbiota
in
influencing
neuroinflammation
through
microbiota–gut–brain
axis,
including
Alzheimer’s
disease
(AD).
This
review
aims
to
provide
a
comprehensive
synthesis
recent
findings
on
involvement
neuroinflammatory
processes
associated
with
AD,
emphasizing
novel
insights
therapeutic
implications.
reveals
that
dysbiosis
AD
patients’
is
linked
heightened
peripheral
central
inflammatory
responses.
Specific
bacterial
taxa,
such
as
Bacteroides
Firmicutes
gut,
well
Porphyromonas
gingivalis
cavity,
are
notably
altered
leading
significant
changes
microglial
activation
cytokine
production.
Gut
alterations
increased
intestinal
permeability,
facilitating
translocation
endotoxins
like
lipopolysaccharides
(LPS)
into
bloodstream
exacerbating
by
activating
brain’s
toll-like
receptor
4
(TLR4)
pathways.
Furthermore,
microbiota-derived
metabolites,
short-chain
fatty
acids
(SCFAs)
amyloid
peptides,
can
cross
blood-brain
barrier
modulate
While
microbial
amyloids
may
contribute
amyloid-beta
aggregation
brain,
certain
SCFAs
butyrate
exhibit
anti-inflammatory
properties,
suggesting
potential
avenue
mitigate
neuroinflammation.
not
only
highlights
critical
pathology
but
also
offers
ray
hope
modulating
could
represent
strategy
for
reducing
slowing
progression.
Язык: Английский
A review of the roles of pathogens in Alzheimer’s disease
Frontiers in Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Авг. 19, 2024
Alzheimer’s
disease
(AD)
is
one
of
the
leading
causes
dementia
and
characterized
by
memory
loss,
mental
behavioral
abnormalities,
impaired
ability
to
perform
daily
activities.
Even
as
a
global
that
threatens
human
health,
effective
treatments
slow
progression
AD
have
not
been
found,
despite
intensive
research
significant
investment.
In
recent
years,
role
infections
in
etiology
has
sparked
intense
debate.
Pathogens
invade
central
nervous
system
through
damaged
blood–brain
barrier
or
nerve
trunk
disrupt
neuronal
structure
function
well
homeostasis
brain
microenvironment
series
molecular
biological
events.
this
review,
we
summarize
various
pathogens
involved
pathology,
discuss
potential
interactions
between
AD,
provide
an
overview
promising
future
anti-pathogenic
therapies
for
AD.
Язык: Английский
mosGraphGPT: a foundation model for multi-omic signaling graphs using generative AI
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 6, 2024
Generative
pretrained
models
represent
a
significant
advancement
in
natural
language
processing
and
computer
vision,
which
can
generate
coherent
contextually
relevant
content
based
on
the
pre-training
large
general
datasets
fine-tune
for
specific
tasks.
Building
foundation
using
scale
omic
data
is
promising
to
decode
understand
complex
signaling
patterns
within
cells.
Different
from
existing
of
data,
we
build
model,
Язык: Английский
Professor Klaus Fassbender: The Father of Mobile Stroke Units
Cureus,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
Professor
Klaus
Fassbender
is
a
distinguished
neurologist
from
Germany,
widely
recognized
for
his
groundbreaking
contributions
to
the
fields
of
neurology
and
neurodegenerative
disease.
His
work
has
been
pivotal
in
advancing
our
understanding
pathophysiological
mechanisms
underlying
disorders,
including
Alzheimer's
Parkinson's
disease,
as
well
refining
therapeutic
strategies
their
treatment.
studies
cerebrovascular
disease
have
elucidated
complex
molecular
cellular
processes
involved
ischemic
hemorrhagic
stroke,
leading
development
novel
interventions,
often
bridging
gap
between
laboratory
discoveries
application
clinical
settings.
"the
father"
mobile
stroke
unit
(MSU).
With
"time
brain"
concept
mind,
he
proposed
developed
MSU
first
time,
allowing
prehospital
imaging,
diagnosis,
treatment
directly
at
site
emergency.
This
reduced
times
symptoms
onset
treatment,
resulting
an
increased
proportion
patients
receiving
within
golden
hour"
improvement
functional
outcomes
90
days.
Fassbender's
instrumental
shaping
contemporary
approaches
diagnosing
managing
making
him
figure
modern
neurology.
Язык: Английский