Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota
Biomolecules,
Год журнала:
2025,
Номер
15(2), С. 270 - 270
Опубликована: Фев. 12, 2025
The
gut-brain-cancer
axis
represents
a
novel
and
intricate
connection
between
the
gut
microbiota,
neurobiology,
cancer
progression.
Recent
advances
have
accentuated
significant
role
of
microbiota
metabolites
in
modulating
systemic
processes
that
influence
both
brain
health
tumorigenesis.
This
paper
explores
emerging
concept
metabolite-mediated
modulation
within
connection,
focusing
on
key
such
as
short-chain
fatty
acids
(SCFAs),
tryptophan
derivatives,
secondary
bile
acids,
lipopolysaccharides
(LPS).
While
microbiota's
impact
immune
regulation,
neuroinflammation,
tumor
development
is
well
established,
gaps
remain
grasping
how
specific
contribute
to
neuro-cancer
interactions.
We
discuss
with
potential
implications
for
neurobiology
cancer,
indoles
polyamines,
which
yet
be
extensively
studied.
Furthermore,
we
review
preclinical
clinical
evidence
linking
dysbiosis,
altered
metabolite
profiles,
tumors,
showcasing
limitations
research
gaps,
particularly
human
longitudinal
studies.
Case
studies
investigating
microbiota-based
interventions,
including
dietary
changes,
fecal
transplantation,
probiotics,
demonstrate
promise
but
also
indicate
hurdles
translating
these
findings
therapies.
concludes
call
standardized
multi-omics
approaches
bi-directional
frameworks
integrating
microbiome,
neuroscience,
oncology
develop
personalized
therapeutic
strategies
patients.
Язык: Английский
The Role of the Gut Microbiota in Modulating Signaling Pathways and Oxidative Stress in Glioma Therapies
Cancers,
Год журнала:
2025,
Номер
17(5), С. 719 - 719
Опубликована: Фев. 20, 2025
Tumors
of
the
central
nervous
system
(CNS),
especially
gliomas,
pose
a
significant
clinical
challenge
due
to
their
aggressive
nature
and
limited
therapeutic
options.
Emerging
research
highlights
critical
role
gut
microbiota
in
regulating
CNS
health
disease.
The
composition
is
essential
for
maintaining
homeostasis,
as
it
modulates
immune
responses,
oxidative
status,
neuroinflammation.
microbiota–gut–brain
axis,
bidirectional
communication
network,
plays
pivotal
cancer
disease
treatment,
exerting
its
influence
through
neural,
endocrine,
immunological,
metabolic
pathways.
Recent
studies
suggest
that
influences
solidification
tumor
microenvironment
dysbiosis
may
promote
glioma
development
by
modulating
systemic
inflammation
stress,
which
contributes
tumorigenesis
progression.
This
review
interrogates
impact
on
glioma,
focusing
pathways
such
NF-κB,
MAPK,
PI3K/Akt/mTOR,
Kynurenine/AhR
drive
proliferation,
evasion,
therapy
resistance.
Furthermore,
we
explore
emerging
strategies,
including
probiotics
microbiota-based
interventions,
show
potential
these
enhancing
immunotherapies
checkpoint
inhibitors.
By
multifaceted
interactions
between
microbiota,
tumors,
this
microbiota-targeted
therapies
manipulation
complement
enhance
current
treatments.
Язык: Английский
The oncobiome; what, so what, now what?
Microbiome Research Reports,
Год журнала:
2025,
Номер
4(1)
Опубликована: Фев. 27, 2025
Microbial
communities
inhabiting
various
body
sites
play
critical
roles
in
the
initiation,
progression,
and
treatment
of
cancer.
The
gut
microbiota,
a
highly
diverse
microbial
ecosystem,
interacts
with
immune
cells
to
modulate
inflammation
surveillance,
influencing
cancer
risk
therapeutic
outcomes.
Local
tissue
microbiota
may
impact
transition
from
premalignant
states
malignancy.
Characterization
intratumoral
increasingly
reveals
distinct
microbiomes
that
influence
tumor
growth,
responses,
efficacy.
Various
bacteria
species
have
been
reported
therapies
through
mechanisms
such
as
altering
drug
metabolism
shaping
microenvironment
(TME).
For
instance,
or
bacterial
enzymatic
activity
can
convert
prodrugs
into
active
forms,
enhancing
effects
or,
conversely,
inactivating
small-molecule
chemotherapeutics.
Specific
also
linked
improved
responses
immunotherapy,
underscoring
microbiome’s
role
Furthermore,
unique
signatures
patients,
compared
healthy
individuals,
demonstrate
diagnostic
potential
microbiota.
Beyond
gut,
tumor-associated
local
affect
therapy
by
inflammation,
resistance.
This
review
explores
multifaceted
relationships
between
cancer,
focusing
on
their
modulating
TME,
activation,
members
represents
promising
avenue
for
advancing
precision
oncology
improving
patient
By
leveraging
biomarkers
interventions,
new
strategies
be
developed
optimize
diagnosis
treatment.
Язык: Английский
The Role of Gut Microbiome on Glioblastoma Oncogenesis and Malignant Evolution
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 2935 - 2935
Опубликована: Март 24, 2025
Glioblastoma
(GBM)
remains
the
most
aggressive
primary
brain
tumor,
with
poor
survival
outcomes
and
treatment
limited
to
maximal
safe
surgical
resection,
chemotherapy
temozolomide,
radiotherapy.
While
immunotherapy
targeted
treatments
show
promise,
therapeutic
resistance
disease
progression
remain
major
challenges.
This
is
partly
due
GBM's
classification
as
a
"cold
tumor"
low
mutational
burden
lack
of
distinct
molecular
targets
for
drug
delivery
that
selectively
spare
healthy
tissue.
Emerging
evidence
highlights
gut
microbiota
key
player
in
cancer
biology,
influencing
both
glioma
development
response.
review
explores
intersectionality
between
microbiome
GBM,
beginning
an
overview
composition
its
broader
implications
pathophysiology.
We
then
examine
how
specific
microbial
populations
contribute
oncogenesis,
modulating
immune
responses,
inflammation,
metabolic
pathways
drive
tumor
initiation
progression.
Additionally,
we
discuss
microbiome's
role
resistance,
including
impact
on
chemotherapy,
radiotherapy,
efficacy.
Given
influence
outcomes,
evaluate
emerging
strategies
modulate
flora,
such
probiotics,
dietary
interventions,
microbiota-based
therapeutics,
enhance
therapy
response
GBM
patients.
Finally,
address
challenges
future
directions,
emphasizing
need
standardized
methodologies,
mechanistic
studies,
clinical
trials
validate
microbiota-targeted
interventions
neuro-oncology.
By
integrating
research
into
paradigms,
may
unlock
novel
avenues
improve
patient
outcomes.
Язык: Английский