Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin
Drug Design Development and Therapy,
Год журнала:
2025,
Номер
Volume 19, С. 771 - 791
Опубликована: Фев. 1, 2025
Acute
myocardial
infarction
(AMI)
is
a
significant
contributor
to
global
morbidity
and
mortality.
Allicin
exhibits
promising
therapeutic
potential
in
AMI
as
primary
bioactive
component
derived
from
garlic;
however,
its
underlying
mechanisms
remain
incompletely
elucidated.
Our
study
induced
mice
by
ligating
the
left
coronary
artery,
administered
allicin
orally
for
28
days.
The
cardioprotective
effects
of
treatment
were
comprehensively
assessed
using
echocardiography,
histopathological
examinations,
intestinal
barrier
function,
serum
inflammatory
factors.
elucidated
through
analysis
metagenomics
metabolomics.
Network
pharmacology
(NP)
was
used
further
investigate
validate
possible
molecular
allicin.
findings
revealed
allicin's
capacity
ameliorate
cardiac
impairments,
improve
integrity,
reduce
IL-18
IL-1β
levels
after
AMI.
Further
demonstrated
that
administration
has
flora
disorder
following
modulating
abundance
beneficial
bacteria,
such
g_Lactobacillus,
g_Prevotella,
g_Alistipes,
g_Limosilactobacillus,
while
reducing
harmful
bacteria
g_Parasutterella.
Additionally,
it
ability
enhance
energy
metabolism
flexibility
metabolites
key
enzymes
associated
with
fatty
acid
metabolic
pathway.
Mechanistically,
NP
vivo
experiments
indicated
might
suppress
pyroptosis
response
via
blocked
activation
NF-κB-mediated
NLRP3/Caspase-1/GSDMD
Moreover,
Spearman
correlation
suggested
association
between
allicin-induced
alterations
microbiota
function
cytokines.
alleviated
injury
reduced
inhibiting
pathway
remodeling
disturbance,
improving
disorder,
enhancing
barrier.
These
research
offer
novel
perspective
on
value
an
adjunctive
dietary
supplement
conventional
treatments
Язык: Английский
Inulin as a Biopolymer; Chemical Structure, Anticancer Effects, Nutraceutical Potential and Industrial Applications: A Comprehensive Review
Polymers,
Год журнала:
2025,
Номер
17(3), С. 412 - 412
Опубликована: Фев. 4, 2025
Inulin
is
a
versatile
biopolymer
that
non-digestible
in
the
upper
alimentary
tract
and
acts
as
bifidogenic
prebiotic
which
selectively
promotes
gut
health
modulates
gut–organ
axes
through
short-chain
fatty
acids
possibly
yet-to-be-known
interactions.
usage
fiber
ingredient
food
has
been
approved
by
FDA
since
June
2018
it
predicted
universal
inulin
market
demand
will
skyrocket
near
future
because
of
its
novel
applications
diseases.
This
comprehensive
review
outlines
known
various
disciplines
ranging
from
medicine
to
industry,
covering
benefits
diseases,
metabolism,
drug
delivery,
therapeutic
pharmacology,
nutrition,
prebiotics
industry.
Furthermore,
this
acknowledges
attention
researchers
knowledge
gaps
regarding
usages
key
modulator
axes.
Язык: Английский
Metabolic disorders in polycystic ovary syndrome: from gut microbiota biodiversity to clinical intervention
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 28, 2025
Polycystic
ovary
syndrome
(PCOS)
is
a
prevalent
gynecologic
endocrine
disorder
characterized
by
menstrual
irregularities,
elevated
androgen
levels,
and
ovulatory
dysfunction.
Its
etiology
multifactorial.
Emerging
evidence
indicates
that
PCOS
patients
exhibit
diminished
gut
microbiota
(GM)
diversity
altered
microbial
ratios,
contributing
to
the
metabolic
derangements
observed
in
these
individuals.
This
review
elucidates
role
of
GM
pathogenesis
disorders
PCOS,
encompassing
insulin
resistance
(IR),
hormonal
imbalances,
bile
acid
disorders,
Interleukin-22-mediated
immune
dysregulation,
brain-gut
axis
disturbances.
Additionally,
it
synthesizes
current
therapeutic
strategies
targeting
GM,
aiming
furnish
theoretical
framework
for
prospective
clinical
interventions.
Язык: Английский
Fructooligosaccharides for Relieving Functional Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Foods,
Год журнала:
2024,
Номер
13(24), С. 3993 - 3993
Опубликована: Дек. 11, 2024
Fructooligosaccharides
(FOS)
are
prebiotics
with
great
potential
to
improve
constipation.
This
study
set
out
investigate
the
usefulness
of
consuming
FOS
as
a
dietary
supplement
on
bowel
movement
frequency,
stool
consistency,
abundance
Bifidobacteria,
gastrointestinal
transit
time,
and
symptoms
through
systematic
review
meta-analysis
randomized
controlled
trials
(RCTs).
We
searched
Cochrane
Library,
PubMed,
EMBASE,
Web
Science
databases
up
2
March
2024.
Randomized
reporting
use
by
participants
were
included.
Bias
risk
was
assessed
using
Risk
assessment
tool.
Results
synthesized
random-effects
model
or
fixed-effects
model,
combining
outcomes
odds
ratios
(OR),
weighted
mean
differences
(MD),
standardized
(SMD)
95%
confidence
intervals
(CI).
The
encompassed
17
trials,
involving
total
713
participants.
Overall,
intake
significantly
increased
frequency
(95%
CI:
0.80,
1.50,
p
<
0.00001)
positively
affected
softening
(SMD:
0.36,
0.12,
0.60,
=
0.76).
It
also
reduced
effort
pain
during
defecation
−0.60,
−0.85,
−0.34,
0.12).
At
same
mild
bloating
noted
an
adverse
event
associated
ingestion
(OR:
10.36,
3.32,
33.23,
0.24).
No
reports
serious
events
documented.
may
enhance
overall
constipation
symptoms,
suggesting
cautious
optimism
regarding
their
treatment
alternative.
Nevertheless,
further
robust
definitive
required
more
accurately
determine
most
effective
dosage
duration
use.
Additional
research
evidence
necessary
before
efficacy
therapeutic
method
for
treating
functional
can
be
firmly
established.
Язык: Английский