Fructooligosaccharides for Relieving Functional Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials DOI Creative Commons
Hongmin Zhen, Hui Qian, Xiaoyan Liu

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 3993 - 3993

Published: Dec. 11, 2024

Fructooligosaccharides (FOS) are prebiotics with great potential to improve constipation. This study set out investigate the usefulness of consuming FOS as a dietary supplement on bowel movement frequency, stool consistency, abundance Bifidobacteria, gastrointestinal transit time, and symptoms through systematic review meta-analysis randomized controlled trials (RCTs). We searched Cochrane Library, PubMed, EMBASE, Web Science databases up 2 March 2024. Randomized reporting use by participants were included. Bias risk was assessed using Risk assessment tool. Results synthesized random-effects model or fixed-effects model, combining outcomes odds ratios (OR), weighted mean differences (MD), standardized (SMD) 95% confidence intervals (CI). The encompassed 17 trials, involving total 713 participants. Overall, intake significantly increased frequency (95% CI: 0.80, 1.50, p < 0.00001) positively affected softening (SMD: 0.36, 0.12, 0.60, = 0.76). It also reduced effort pain during defecation −0.60, −0.85, −0.34, 0.12). At same mild bloating noted an adverse event associated ingestion (OR: 10.36, 3.32, 33.23, 0.24). No reports serious events documented. may enhance overall constipation symptoms, suggesting cautious optimism regarding their treatment alternative. Nevertheless, further robust definitive required more accurately determine most effective dosage duration use. Additional research evidence necessary before efficacy therapeutic method for treating functional can be firmly established.

Language: Английский

Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin DOI Creative Commons
Yijie Gao,

Gaofeng Qin,

Shichao Liang

et al.

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 771 - 791

Published: Feb. 1, 2025

Acute myocardial infarction (AMI) is a significant contributor to global morbidity and mortality. Allicin exhibits promising therapeutic potential in AMI as primary bioactive component derived from garlic; however, its underlying mechanisms remain incompletely elucidated. Our study induced mice by ligating the left coronary artery, administered allicin orally for 28 days. The cardioprotective effects of treatment were comprehensively assessed using echocardiography, histopathological examinations, intestinal barrier function, serum inflammatory factors. elucidated through analysis metagenomics metabolomics. Network pharmacology (NP) was used further investigate validate possible molecular allicin. findings revealed allicin's capacity ameliorate cardiac impairments, improve integrity, reduce IL-18 IL-1β levels after AMI. Further demonstrated that administration has flora disorder following modulating abundance beneficial bacteria, such g_Lactobacillus, g_Prevotella, g_Alistipes, g_Limosilactobacillus, while reducing harmful bacteria g_Parasutterella. Additionally, it ability enhance energy metabolism flexibility metabolites key enzymes associated with fatty acid metabolic pathway. Mechanistically, NP vivo experiments indicated might suppress pyroptosis response via blocked activation NF-κB-mediated NLRP3/Caspase-1/GSDMD Moreover, Spearman correlation suggested association between allicin-induced alterations microbiota function cytokines. alleviated injury reduced inhibiting pathway remodeling disturbance, improving disorder, enhancing barrier. These research offer novel perspective on value an adjunctive dietary supplement conventional treatments

Language: Английский

Citations

1
Inulin as a Biopolymer; Chemical Structure, Anticancer Effects, Nutraceutical Potential and Industrial Applications: A Comprehensive Review DOI Open Access
Isaac Karimi, Mahnaz Ghowsi, Layth Jasim Mohammed

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(3), P. 412 - 412

Published: Feb. 4, 2025

Inulin is a versatile biopolymer that non-digestible in the upper alimentary tract and acts as bifidogenic prebiotic which selectively promotes gut health modulates gut–organ axes through short-chain fatty acids possibly yet-to-be-known interactions. usage fiber ingredient food has been approved by FDA since June 2018 it predicted universal inulin market demand will skyrocket near future because of its novel applications diseases. This comprehensive review outlines known various disciplines ranging from medicine to industry, covering benefits diseases, metabolism, drug delivery, therapeutic pharmacology, nutrition, prebiotics industry. Furthermore, this acknowledges attention researchers knowledge gaps regarding usages key modulator axes.

Language: Английский

Citations

0
Metabolic disorders in polycystic ovary syndrome: from gut microbiota biodiversity to clinical intervention DOI Creative Commons
Jiyuan Li, Jie Qiao, Yihan Li

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Polycystic ovary syndrome (PCOS) is a prevalent gynecologic endocrine disorder characterized by menstrual irregularities, elevated androgen levels, and ovulatory dysfunction. Its etiology multifactorial. Emerging evidence indicates that PCOS patients exhibit diminished gut microbiota (GM) diversity altered microbial ratios, contributing to the metabolic derangements observed in these individuals. This review elucidates role of GM pathogenesis disorders PCOS, encompassing insulin resistance (IR), hormonal imbalances, bile acid disorders, Interleukin-22-mediated immune dysregulation, brain-gut axis disturbances. Additionally, it synthesizes current therapeutic strategies targeting GM, aiming furnish theoretical framework for prospective clinical interventions.

Language: Английский

Citations

0
Fructooligosaccharides for Relieving Functional Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials DOI Creative Commons
Hongmin Zhen, Hui Qian, Xiaoyan Liu

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 3993 - 3993

Published: Dec. 11, 2024

Fructooligosaccharides (FOS) are prebiotics with great potential to improve constipation. This study set out investigate the usefulness of consuming FOS as a dietary supplement on bowel movement frequency, stool consistency, abundance Bifidobacteria, gastrointestinal transit time, and symptoms through systematic review meta-analysis randomized controlled trials (RCTs). We searched Cochrane Library, PubMed, EMBASE, Web Science databases up 2 March 2024. Randomized reporting use by participants were included. Bias risk was assessed using Risk assessment tool. Results synthesized random-effects model or fixed-effects model, combining outcomes odds ratios (OR), weighted mean differences (MD), standardized (SMD) 95% confidence intervals (CI). The encompassed 17 trials, involving total 713 participants. Overall, intake significantly increased frequency (95% CI: 0.80, 1.50, p < 0.00001) positively affected softening (SMD: 0.36, 0.12, 0.60, = 0.76). It also reduced effort pain during defecation −0.60, −0.85, −0.34, 0.12). At same mild bloating noted an adverse event associated ingestion (OR: 10.36, 3.32, 33.23, 0.24). No reports serious events documented. may enhance overall constipation symptoms, suggesting cautious optimism regarding their treatment alternative. Nevertheless, further robust definitive required more accurately determine most effective dosage duration use. Additional research evidence necessary before efficacy therapeutic method for treating functional can be firmly established.

Language: Английский

Citations

0