Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance

Cancer Cell, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Interactions between mitochondrial dysfunction and other hallmarks of aging: Paving a path toward interventions that promote healthy old age

Aging Cell, Год журнала: 2023, Номер 23(1)

Опубликована: Июль 27, 2023

Abstract Current research on human aging has largely been guided by the milestone paper “hallmarks of aging,” which were first proposed in seminal 2013 Lopez‐Otin et al. Most studies have focused one hallmark at a time, asking whether underlying molecular perturbations are sufficient to drive process and its associated phenotypes. More recently, researchers begun investigate phenotypes driven concurrent pathways linked not but multiple hallmarks they present different patterns organs systems over time. Indeed, preliminary results suggest that more complex interactions between must be considered addressed, if we develop interventions successfully promote healthy and/or delay aging‐associated dysfunction diseases. Here, summarize some latest work views interplay aging, with specific focus mitochondrial dysfunction. this represents significant example crosstalk effects an intervention targeted may others. A better knowledge these interconnections, their cause‐effect relationships, spatial temporal sequence, will very beneficial for whole field identification effective promoting old age.

Язык: Английский

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Muscle mitochondrial transplantation can rescue and maintain cellular homeostasis

AJP Cell Physiology, Год журнала: 2023, Номер 325(4), С. C862 - C884

Опубликована: Авг. 14, 2023

Mitochondria control cellular functions through their metabolic role. Recent research that has gained considerable attention is ability to transfer between cells. This the potential of improving in pathological or energy-deficit conditions, but little known about role mitochondrial sustaining homeostasis. Few studies have investigated skeletal muscle as a source healthy mitochondria can be transferred other cell types. Thus, we isolated intermyofibrillar from murine and incubated them with host We observed dose- time-dependent increases incorporation into myoblasts. resulted elongated networks an enhancement bioenergetic profile Mitochondrial donation also rejuvenated functional capacities myoblasts when respiration efficiency lysosomal function were inhibited by complex I inhibitor rotenone bafilomycin A, respectively. was accomplished via tunneling nanotubes, extracellular vesicles, gap junctions, macropinocytosis internalization. Murine effectively human fibroblast cells having DNA mutations, resulting augmented dynamics functions. improved diminishing reactive oxygen species (ROS) emission diseased Our findings suggest donor integrated both functionally compromised leading structural refinement respiratory boost. trafficking reprogramming maintain revitalize tissue homeostasis could useful therapeutic strategy treating diseases.NEW & NOTEWORTHY In our study, shown mouse transplanted mutations. augmentation

Язык: Английский

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Therapeutic Effects of Mesenchymal Stromal Cells Require Mitochondrial Transfer and Quality Control

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(21), С. 15788 - 15788

Опубликована: Окт. 31, 2023

Due to their beneficial effects in an array of diseases, Mesenchymal Stromal Cells (MSCs) have been the focus intense preclinical research and clinical implementation for decades. MSCs multilineage differentiation capacity, support hematopoiesis, secrete pro-regenerative factors exert immunoregulatory functions promoting homeostasis resolution injury/inflammation. The main include modulation immune cells (macrophages, neutrophils, lymphocytes), secretion antimicrobial peptides, transfer mitochondria (Mt) injured cells. These actions can be enhanced by priming (i.e., licensing) prior exposure deleterious microenvironments. Preclinical evidence suggests that therapeutic a variety pathological states, including cardiac, respiratory, hepatic, renal, neurological diseases. One key emerging is improvement mitochondrial tissues enhancing quality control (MQC). Recent advances understanding cellular MQC, biogenesis, mitophagy, fission, fusion, helped uncover how enhance these processes. Specifically, suggested regulate peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC1α)-dependent Parkin-dependent Mitofusins (Mfn1/2) or Dynamin Related Protein-1 (Drp1)-mediated fission/fusion. In addition, previous studies also verified from through tunneling nanotubes via microvesicular transport. Combined, improve functions, thereby contributing injury inflammation. Thus, uncovering affect MQC opens new avenues organ injury, transplantation MSC-derived might represent attractive approach.

Язык: Английский

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Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2023, Номер 1878(5), С. 188940 - 188940

Опубликована: Июнь 16, 2023

Язык: Английский

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Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Ноя. 15, 2023

Aging of human skin is a complex process leading to decline in homeostasis and regenerative potential this tissue. Mitochondria are important cell organelles that have crucial role several cellular mechanisms such as energy production free radical maintenance. However, mitochondrial metabolism well processes dynamics, biogenesis, degradation varies considerably among the different types cells populate skin. Disturbed function known promote aging inflammation skin, impairment physiological onset pathologies. In review, we discuss essential mitochondria how morphology, physiology, each these compartments contributes aging.

Язык: Английский

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The Research Progress of Mitochondrial Transplantation in the Treatment of Mitochondrial Defective Diseases

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 1175 - 1175

Опубликована: Янв. 18, 2024

Mitochondria are double-membrane organelles that involved in energy production, apoptosis, and signaling eukaryotic cells. Several studies conducted over the past decades have correlated mitochondrial dysfunction with various diseases, including cerebral ischemia, myocardial ischemia-reperfusion, cancer. Mitochondrial transplantation entails importing intact mitochondria from healthy tissues into diseased damaged to rescue injured In this review, different techniques their clinical applications been discussed. addition, challenges future directions pertaining its potential treatment of diseases defective summarized.

Язык: Английский

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Carcinoma-associated mesenchymal stem cells promote ovarian cancer heterogeneity and metastasis through mitochondrial transfer

Cell Reports, Год журнала: 2024, Номер 43(8), С. 114551 - 114551

Опубликована: Июль 26, 2024

Язык: Английский

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The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria

Clinical & Experimental Metastasis, Год журнала: 2024, Номер 41(5), С. 567 - 587

Опубликована: Март 15, 2024

Abstract As a major energy source for cells, mitochondria are involved in cell growth and proliferation, as well migration, fate decisions, many other aspects of cellular function. Once thought to be irreparably defective, mitochondrial function cancer cells has found renewed interest, from suggested potential clinical biomarkers mitochondria-targeting therapies. Here, we will focus on the effect movement breast progression. Mitochondria move both within cell, such localize areas high energetic need, between where stroma have been shown donate their via multiple methods including tunneling nanotubes. The donation seen increase aggressiveness chemoresistance which increased recent efforts uncover mechanisms transfer. metabolism energetics gaining attention targets, better understanding implications required developing effective, targeted therapeutics patients.

Язык: Английский

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Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

Abstract Lipid metabolism disorders in both neurons and glial cells have been found neurodegenerative (ND) patients animal models. However, the pathological connection between lipid droplets NDs remains poorly understood. The recent work has highlighted utility of a neuron‐specific Arf1‐knockout mouse model corresponding for elucidating nexus amyotrophic lateral sclerosis (ALS) multiple (MS). In this study, it is that Arf1 deficiency first induced surplus fatty acid synthesis through AKT‐mTORC1‐SREBP1‐FASN axis, which further triggered endoplasmic reticulum (ER)‐mitochondrial stress cascade via calcium flux. organelle caused mitochondrial DNA (mtDNA) to be released into cytoplasm. Concurrently, FASN‐driven Arf1‐deficient might also induce accumulation sphingolipids lysosomes dysfunction autophagy lysosomes, promoted lysosomal mitochondria‐derived extracellular vesicles (MDEVs) release. MDEVs carried mtDNA microglia activate inflammatory pathways neurodegeneration. studies on neuronal (LDs) microglial LDs suggest unified function NDs: activating microglia. This finding potentially provides new therapeutic strategies NDs.

Язык: Английский

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