Mitochondrial-Derived Vesicles: The Good, the Bad, and the Ugly

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(18), С. 13835 - 13835

Опубликована: Сен. 8, 2023

Mitophagy is crucial for maintaining mitochondrial quality. However, its assessment in vivo challenging. The endosomal-lysosomal system a more accessible pathway through which subtypes of extracellular vesicles (EVs), also contain constituents, are released disposal. inclusion components into EVs occurs the setting mild damage and during impairment lysosomal function. By releasing mitochondrial-derived (MDVs), cells limit unload damage-associated molecular patterns with proinflammatory activity. Both positive negative effects on recipient have been described. Whether this due to production other than those containing mitochondria, such as MDVs, holding specific biological functions currently unknown. Evidence existence different MDV has produced. their characterization not always pursued, would be relevant exploring dynamics quality control health disease. Furthermore, classification may instrumental understanding roles promoting implementation biomarkers clinical studies.

Язык: Английский

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Mitochondrial Quantity and Quality in Age-Related Sarcopenia

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2052 - 2052

Опубликована: Фев. 8, 2024

Sarcopenia, the age-associated decline in skeletal muscle mass and strength, is a condition with complex pathophysiology. Among factors underlying development of sarcopenia are progressive demise motor neurons, transition from fast to slow myosin isoform (type II type I fiber switch), decrease satellite cell number function. Mitochondrial dysfunction has been indicated as key contributor myocyte loss physical performance aging. Several systems have implicated regulation plasticity trophism such fine-tuned between stimulator protein synthesis, mechanistic target rapamycin (mTOR), inhibitor mTOR, AMP-activated kinase (AMPK), that promotes catabolism. Here, we provide an overview molecular mechanisms linking mitochondrial signaling quality homeostasis discuss main pathways elicited by their imbalance during age-related wasting. We also lifestyle interventions (i.e., exercise nutrition) may be exploited preserve function aged muscle. Finally, illustrate emerging possibility rescuing tissue through transplantation.

Язык: Английский

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Restoring Mitochondrial Function and Muscle Satellite Cell Signaling: Remedies against Age-Related Sarcopenia

Biomolecules, Год журнала: 2024, Номер 14(4), С. 415 - 415

Опубликована: Март 28, 2024

Sarcopenia has a complex pathophysiology that encompasses metabolic dysregulation and muscle ultrastructural changes. Among the drivers of intracellular changes fibers in sarcopenia, mitochondria their quality control pathways play relevant roles. Mononucleated stem cells/satellite cells (MSCs) have been attributed critical role repair after an injury. The involvement supporting MSC-directed is unclear. There evidence reduction mitochondrial biogenesis blunts repair, thus indicating delivery functional to injured muscles can be harnessed limit fibrosis enhance restoration function. Injection autologous respiration-competent from uninjured sites damaged tissue shown reduce infarct size cell survival preclinical models ischemia-reperfusion. Furthermore, incorporation donor into MSCs enhances lung cardiac repair. This strategy also tested for regeneration purposes traumatic injuries. Indeed, systemic promotes restores mass function while reducing during recovery In this review, we discuss contribution altered MSC sarcopenia illustrate prospect harnessing as therapeutic against age-related sarcopenia.

Язык: Английский

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Effects of mitochondrial transplantation on chronic pressure wound healing in a human patient

Cytotherapy, Год журнала: 2024, Номер 26(6), С. 579 - 585

Опубликована: Март 4, 2024

Язык: Английский

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From exosomes to mitochondria and myocardial infarction: molecular insight and therapeutic challenge

Pharmacological Research, Год журнала: 2024, Номер 209, С. 107468 - 107468

Опубликована: Окт. 18, 2024

Myocardial infarction (MI) remains a leading cause of mortality worldwide. Despite patients with MI benefit from timely reperfusion therapies, the rates and morbidity remain substantial, suggesting an enduring need for development new approaches. Molecular mechanisms underlying myocardial ischemic injury are associated both cardiomyocytes non-cardiomyocytes. Exosomes nano-sized extracellular vesicles released by almost all eukaryotic cells. They facilitate communication between various cells transferring information via their cargo altering different biological activities in recipient Studies have created great prospects therapeutic applications exosomes MI, as demonstrated through beneficial effect on heart function reducing ventricular remodeling association fibrosis, angiogenesis, apoptosis, inflammation. Of note, is primarily due to restricted blood flow, oxygen availability, causing inefficient utilization energy substrates. However, impact cardiac metabolism has not been adequately investigated. Although engineered targeted delivery enhance clinical efficacy, challenges must be overcome utilize them reliably clinic. In this review, we summarize research progress focus known unknown regarding role non-cardiomyocytes; well potential avenues exosome-mitochondrial regulation challenges. We aim help identify more efficient molecular targets that may promote application exosomes.

Язык: Английский

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The Research Progress of Mitochondrial Transplantation in the Treatment of Mitochondrial Defective Diseases

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 1175 - 1175

Опубликована: Янв. 18, 2024

Mitochondria are double-membrane organelles that involved in energy production, apoptosis, and signaling eukaryotic cells. Several studies conducted over the past decades have correlated mitochondrial dysfunction with various diseases, including cerebral ischemia, myocardial ischemia-reperfusion, cancer. Mitochondrial transplantation entails importing intact mitochondria from healthy tissues into diseased damaged to rescue injured In this review, different techniques their clinical applications been discussed. addition, challenges future directions pertaining its potential treatment of diseases defective summarized.

Язык: Английский

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Engineered Mitochondrial Transplantation as An Anti-Aging Therapy

Aging and Disease, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Aging is an inevitable and complex biological process involving multi-factorial mechanisms. Mitochondrial dysfunction a critical factor in the aging process, characterized by decline mitochondrial quality activity, leading to aging-related diseases. Therefore, mitochondria have become attractive target anti-aging therapies. Several senolytic drugs targeting antioxidant agents been used research past few years. However, these strategies may cause adverse effects with long-term medication. In this extensive review, we propose "mitochondrial transplantation," which transfers healthy from donor cells recipient replace damaged or dysfunctional mitochondria, as new alternative strategy for treating aging-associated introduce contemporary landscape of transplantation, then discuss intensely successful applications transplantation therapy diseases such neurodegenerative diseases, cardiovascular aging, reproductive highlighting its translational potential. Finally, summarize prospect challenges opportunities faces therapy.

Язык: Английский

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Program with last minute abstracts of the Padua Days on Muscle and Mobility Medicine, 27 February – 2 March, 2024 (2024Pdm3)

European Journal of Translational Myology, Год журнала: 2024, Номер unknown

Опубликована: Фев. 2, 2024

During the 2023 Padua Days on Muscle and Mobility Medicine 2024 meeting was scheduled from 28 February to 2 March (2024Pdm3). autumn program expanded with Scientific Sessions which will take place over five days (in this includes 29), starting afternoon of 27 in Conference Rooms Hotel Petrarca, Thermae Euganean Hills (Padua), Italy. As per consolidated tradition, second day Padua, for occasion Sala San Luca Monastery Santa Giustina Prato della Valle, Confirming attractiveness Medicine, 100 titles were accepted until 15 December (many more than expected), forcing organization parallel sessions both 1 2024. The include lectures oral presentations scientists clinicians Argentina, Austria, Belgium, Brazil, Bulgaria, Canada, Denmark, Egypt, France, Germany, Iceland, Ireland, Italy, Romania, Russia, Slovenia, Switzerland, UK USA. Only Australia, China, India Japan are missing edition. But we confident that authors those countries who publish articles PAGEpress: European Journal Translational Myology (EJTM: 2022 ESCI Clarivate's Impact Factor: 2.2; SCOPUS Cite Score: 3.2) decide join us coming years. Together established by 31 January 2024, abstracts circulate during only electronic version EJTM Issue 34 (1) See you soon person at Petrarca Montegrotto Terme, inauguration or on-line free via Zoom. Send your email address if not traditional participants listed Pdm3 books.

Язык: Английский

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Mitochondrial transplantation: a promising strategy for treating degenerative joint diseases

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Окт. 15, 2024

The prevalence of age-related degenerative joint diseases, particularly intervertebral disc degeneration and osteoarthritis, is increasing, thereby posing significant challenges for the elderly population. Mitochondrial dysfunction a critical factor in etiology progression these disorders. Therapeutic interventions that incorporate mitochondrial transplantation exhibit considerable promise by increasing numbers improving their functionality. Existing evidence suggests exogenous therapy improves clinical outcomes patients with diseases. This review elucidates abnormalities associated diseases examines mechanisms intercellular transfer artificial transplantation. Furthermore, therapeutic strategies are synthesized, concept engineered proposed.

Язык: Английский

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Osteoblast‐Derived Mitochondria Formulated with Cationic Liposome Guide Mesenchymal Stem Cells into Osteogenic Differentiation

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Abstract While mitochondria are known to be essential for intracellular energy production and overall function, emerging evidence highlights their role in influencing cell behavior through mitochondrial transfer. This phenomenon provides a potential basis the development of treatment strategies tissue damage degeneration. study aims evaluate whether isolated from osteoblasts can promote osteogenic differentiation mesenchymal stem cells (MSCs). Mitochondria MSCs, which primarily utilize glycolysis, compared with those MG63 cells, depend on oxidative phosphorylation. both types then encapsulated cationic liposomes transferred impact is assessed. delivery MSCs grown two‐ three‐dimensional cultures results increased expression markers, including Runt‐related transcription factor 2, Osterix, Osteopontin, upregulation genes involved Bone morphogenetic protein 2 signaling calcium import. accompanied by influx regulated Wnt/β‐catenin pathway. Transplantation spheroids containing MG63‐derived bone defect animal models improves regeneration. The suggest that effectively guides toward osteogenesis, paving way mitochondria‐transplantation therapies.

Язык: Английский

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