The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

Cancer Cell, Год журнала: 2023, Номер 41(3), С. 374 - 403

Опубликована: Март 1, 2023

Язык: Английский

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Intratumoral heterogeneity in cancer progression and response to immunotherapy

Nature Medicine, Год журнала: 2021, Номер 27(2), С. 212 - 224

Опубликована: Фев. 1, 2021

Язык: Английский

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Clinical relevance of tumour-associated macrophages

Nature Reviews Clinical Oncology, Год журнала: 2022, Номер 19(6), С. 402 - 421

Опубликована: Март 30, 2022

Язык: Английский

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CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment

Cell, Год журнала: 2021, Номер 184(17), С. 4512 - 4530.e22

Опубликована: Авг. 1, 2021

Язык: Английский

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Dendritic cell subsets in cancer immunity and tumor antigen sensing

Cellular and Molecular Immunology, Год журнала: 2023, Номер 20(5), С. 432 - 447

Опубликована: Март 22, 2023

Abstract Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles in both innate adaptive immune responses. Due to their ability cross-present tumor cell-associated antigens naïve T cells, DCs are instrumental the generation of specific T-cell-mediated antitumor effector responses control growth cell dissemination. Within an immunosuppressive microenvironment, DC functions can, however, be severely impaired. In this review, we focus on mechanisms capture activation by role microenvironment shaping functions, taking advantage recent studies showing phenotype acquisition, transcriptional state functional programs revealed scRNA-seq analysis. The therapeutic potential DC-mediated antigen sensing priming immunity is also discussed.

Язык: Английский

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CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers

Science, Год журнала: 2023, Номер 381(6657), С. 515 - 524

Опубликована: Авг. 3, 2023

Tumor microenvironments (TMEs) influence cancer progression but are complex and often differ between patients. Considering that microenvironment variations may reveal rules governing intratumoral cellular programs disease outcome, we focused on tumor-to-tumor variation to examine 52 head neck squamous cell carcinomas. We found macrophage polarity-defined by

Язык: Английский

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Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity

Immunity, Год журнала: 2021, Номер 55(2), С. 308 - 323.e9

Опубликована: Ноя. 19, 2021

Язык: Английский

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A neutrophil response linked to tumor control in immunotherapy

Cell, Год журнала: 2023, Номер 186(7), С. 1448 - 1464.e20

Опубликована: Март 1, 2023

Язык: Английский

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The role of dendritic cells in cancer and anti-tumor immunity

Seminars in Immunology, Год журнала: 2021, Номер 52, С. 101481 - 101481

Опубликована: Фев. 1, 2021

Язык: Английский

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Human dendritic cells in cancer

Science Immunology, Год журнала: 2022, Номер 7(70)

Опубликована: Апрель 1, 2022

Dendritic cells (DCs) are professional antigen-presenting cells, orchestrating innate and adaptive immunity during infections, autoimmune diseases, malignancies. Since the discovery of DCs almost 50 years ago, our understanding their biology in humans has increased substantially. Here, we review both antitumor tolerogenic DC responses cancer discuss lineage-specific contributions by functionally specialized subsets, including conventional (cDC) subsets cDC1 cDC2, newly described DC3, plasmacytoid (pDCs), focusing on human setting. In addition, lineage-unrestricted "mature enriched immunoregulatory molecules" (mregDC) state recently across different tumors.

Язык: Английский

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